Evidence map›Paper›PMID 28342090›Full record

ArticlePsychopharmacology2017

The effect of varenicline and nicotine patch on smoking rate and satisfaction with smoking: an examination of the mechanism of action of two pre-quit pharmacotherapies.

Wenying Lu, Kate Chappell, Julia A E Walters, Glenn A Jacobson, Rahul Patel, Natalie Schüz, Stuart G Ferguson

Abstract read
PubMed Publisher
In one paragraph

Article in Psychopharmacology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Evaluating Treatment Mechanisms of Varenicline: Mediation by Affect and Craving.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2022
    Trial
  4. Trial
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Wenying LuSchool of Medicine, University of Tasmania, Hobart, TAS, 7001, Australia.
Kate ChappellMenzies Institute for Medical Research, University of Tasmania, Hobart, Australia.
Julia A E WaltersSchool of Medicine, University of Tasmania, Hobart, TAS, 7001, Australia.
Glenn A JacobsonSchool of Medicine, University of Tasmania, Hobart, TAS, 7001, Australia.
Rahul PatelSchool of Medicine, University of Tasmania, Hobart, TAS, 7001, Australia.
Natalie SchüzSchool of Health Science, University of Tasmania, Hobart, Australia.
Stuart G FergusonSchool of Medicine, University of Tasmania, Private Bag 34, Hobart, TAS, 7001, Australia. stuart.ferguson@utas.edu.au.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesIn recent years, there has been growing research interest in using nicotine replacement medications to aid smoking reduction prior to a quit attempt. Gaining a better understanding of how treatments influence smoking reduction may allow for better tailoring of treatments and, ultimately, better cessation outcomes. The objective of the current study was to test the effects of the pre-quit use of varenicline and nicotine patch on smoking rate and satisfaction with smoking.

methodsAll participants were required to attend up to five study visit sections. Participants (n = 213) who were interested in quitting were randomised (open-label) to receive either pre-quit patch or varenicline (both treatments started 2 weeks prior to an assigned quit day, followed by 10 weeks post-quit) or standard patch (10 weeks starting from an assigned quit day). Participants used modified smartphones to monitor their smoking in real time for 4 weeks.

resultsParticipants in the two pre-quit treatment groups reported significant reductions in both their satisfaction with smoking (p < 0.001) and smoking rate (p < 0.001) from baseline to the end of pre-quit period; participants in the standard patch group did not. The observed reduction of smoking rate was associated with the satisfaction with smoking (p < 0.01), although the mediation effect of satisfaction was small.

conclusionsPre-quit treatment caused reductions in satisfaction with smoking and smoking rate. Satisfaction was associated with changes in smoking rate, but the relationship was weak. As such, monitoring reductions in satisfaction do not appear to be a viable method of evaluating responsiveness to treatment.

Indexed as

Tobacco Use Cessation DevicesHumansNicotineNicotinic AgonistsPersonal SatisfactionResearch DesignSmartphoneSmoking CessationSubstance Withdrawal SyndromeTobacco SmokingVareniclineNicotineNicotinic AgonistsVareniclineNicotine patchNicotine replacement therapySatisfactionSmoking cessationVarenicline

Identifiers

PMID28342090

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.