ArticlePsychopharmacology2017
Voluntary induction and maintenance of alcohol dependence in rats using alcohol vapor self-administration.
Article in Psychopharmacology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 44 citations in OpenAlex.
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- Theoretical Frameworks and Mechanistic Aspects of Alcohol Addiction: Alcohol Addiction as a Reward Deficit/Stress Surfeit Disorder.Current topics in behavioral neurosciences · 2025Review
- Enhancing translation: A need to leverage complex preclinical models of addictive drugs to accelerate substance use treatment options.Pharmacology, biochemistry, and behavior · 2024Review
- Cue-induced reinstatement of seeking behavior in male rats is independent from the rewarding value of the primary reinforcer: Effect of mGluR5 blockade.Neuropharmacology · 2023Article
- Voluntary and forced exposure to ethanol vapor produces similar escalation of alcohol drinking but differential recruitment of brain regions related to stress, habit, and reward in male rats.Neuropharmacology · 2023Article
- Comorbidity of Post-Traumatic Stress Disorder and Alcohol Use Disorder: Animal Models and Associated Neurocircuitry.International journal of molecular sciences · 2022Review
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- Behavioral effects of ethanol in the Red Swamp Crayfish (Procambarus clarkii).Journal of the experimental analysis of behavior · 2022Article
- Animal Models to Investigate the Impact of Flavors on Nicotine Addiction and Dependence.Current neuropharmacology · 2022Review
- Animal Models of the Behavioral Symptoms of Substance Use Disorders.Cold Spring Harbor perspectives in medicine · 2021Review
- Operant Vapor Self-administration in Mice.Bio-protocol · 2021Article
- Glucocorticoid receptor modulators decrease alcohol self-administration in male rats.Neuropharmacology · 2021Article
- Studying Sex Differences in Rodent Models of Addictive Behavior.Current protocols · 2021Article
- The Convergent Neuroscience of Affective Pain and Substance Use Disorder.Alcohol research : current reviews · 2021Review
- Demand for fentanyl becomes inelastic following extended access to fentanyl vapor self-administration.Neuropharmacology · 2021Article
- Translational approach to understanding momentary factors associated with alcohol consumption.British journal of pharmacology · 2020Review
- Oxycodone self-administration and withdrawal behaviors in male and female Wistar rats.Psychopharmacology · 2020Article
- Timing Eclipses Amount: The Critical Importance of Intermittency in Alcohol Exposure Effects.Alcoholism, clinical and experimental research · 2020Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
rationaleA major issue in the addiction field is the limited number of animal models of the voluntary induction and maintenance of alcohol dependence in outbred rats.
objectivesTo address this issue, we developed a novel apparatus that vaporizes alcohol for 2-10 min after an active nosepoke response.
methodsMale Wistar rats were allowed to self-administer alcohol vapor for 8 h/day every other day for 24 sessions (escalated) or eight sessions (non-escalated). Escalated and non-escalated rats were then tested for progressive ratio responding. Anxiety-like behavior, somatic signs of withdrawal, and hyperalgesia were assessed during acute withdrawal.
resultsThe results showed that rats exhibited excellent discrimination between the active and inactive operanda (>85%), and the escalated rats quickly increased their blood alcohol levels from ~50 to >200 mg% in ~6 weeks. Compared with non-escalated rats, escalated rats exhibited severe addiction-like behavior, including somatic signs of withdrawal, anxiety-like behavior, hyperalgesia, and higher responding on a progressive ratio schedule of reinforcement.
conclusionsThese results demonstrate that outbred rats will voluntarily self-administer alcohol vapor to the point of dependence without the use of forced alcohol administration, sweeteners, food/water restriction, operant pretraining, or behavioral/genetic selection. This novel animal model may be particularly useful for medication development to help unveil the neuronal circuitry that underlies the voluntary induction of alcohol addiction and identify novel molecular targets that are specifically recruited after the voluntary induction and maintenance of alcohol dependence.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.