Evidence map›Paper›PMID 28342060›Full record

ArticleHead and neck pathology2017

Glycogen-Rich Clear Cell Squamous Cell Carcinoma Originating in the Oral Cavity.

Zaid H Khoury, Amr Bugshan, Joshua E Lubek, John C Papadimitriou, John R Basile, Rania H Younis

Open access · bronzeAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Head and neck pathology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
0.7field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.

  1. Pooled it
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  5. Review
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  7. Review
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  11. Clear-cell variant of oral squamous cell carcinoma: A rare entity.Journal of oral and maxillofacial pathology : JOMFP · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Zaid H KhouryDepartment of Oncology and Diagnostic Sciences, School of Dentistry, University of Maryland Baltimore, 650 West Baltimore Street, 7th Floor North, Baltimore, MD, 21201, USA. khouryzh@umaryland.edu.
Amr BugshanDepartment of Diagnostic Sciences, School of Dental Medicine, Tufts University, Boston, MA, 02111, USA.
Joshua E LubekDepartment of Oral and Maxillofacial Surgery, School of Dentistry, University of Maryland Baltimore, Baltimore, MD, 21201, USA.
John C PapadimitriouDepartment of Pathology, School of Medicine, University of Maryland Baltimore, Baltimore, MD, 21201, USA.
John R BasileDepartment of Oncology and Diagnostic Sciences, School of Dentistry, University of Maryland Baltimore, 650 West Baltimore Street, 7th Floor North, Baltimore, MD, 21201, USA.
Rania H YounisDepartment of Oncology and Diagnostic Sciences, School of Dentistry, University of Maryland Baltimore, 650 West Baltimore Street, 7th Floor North, Baltimore, MD, 21201, USA.
University of Maryland, Baltimore · USDammam Central Hospital · SA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Clear cell squamous cell carcinoma (CCSCC) is a rare histological subtype of squamous cell carcinoma (SCC) that was originally described in the skin. Here, we report a case of a 66-year-old female patient who presented with a fungating ulcerative mass of the left lateral tongue extending anteriorly to the floor of the mouth, and posteriorly to the left retromolar fossa and the oropharynx. The patient had a history of SCC of the left posterior tongue that was treated with partial glossectomy and adjuvant radiotherapy. Representative biopsies were obtained from the floor of the mouth, tongue and retromolar fossa. The examined biopsies showed various degrees of dysplastic surface epithelium with transition into infiltrating epithelial tumor nests and cords with clear cytoplasm and malignant cellular features. Pancytokeratin, CK5/6, and p63 were all diffusely positive. S-100, Calponin, and smooth muscle actin (SMA) were negative. PAS stain was diffusely positive and diastase labile in the tumor clear cells. Sparse areas of mucicarmine positivity were noted. Based on these findings a final diagnosis of a glycogen-rich CCSCC was given. This case represents a very rare histological variant of oral SCC, which is significant for the histological differential diagnosis of clear cell tumors of the oral cavity.

Indexed as

AgedCarcinoma, Squamous CellFemaleGlycogenHead and Neck NeoplasmsHumansMouth NeoplasmsNeoplasm Recurrence, LocalSquamous Cell Carcinoma of Head and NeckGlycogenClear cellGlycogenOral cavityPrognosisSquamous cell carcinoma

Identifiers

PMID28342060
PMCPMC5677064
OpenAlexW2603155386

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.