ArticleActa neuropathologica2017
Immunological memory to hyperphosphorylated tau in asymptomatic individuals.
Open access · hybridAbstract read
In one paragraph
Article in Acta neuropathologica, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
6.8field-weighted citation impact, top 3% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 50 citations in OpenAlex.
- Adaptive immunity in the pathogenesis of neurodegeneration.Nature immunology · 2026Review
- Chimeric Antigen Receptor Cell Therapy: Current Status and Its Potential in Aging and Alzheimer's Disease.International journal of molecular sciences · 2025Review
- High-affinity antibodies specific to the core region of the tau protein exhibit diagnostic and therapeutic potential for Alzheimer's disease.Alzheimer's research & therapy · 2024Article
- Single-domain antibodies and aptamers drive new opportunities for neurodegenerative disease research.Frontiers in immunology · 2024Review
- Role of Specific Autoantibodies in Neurodegenerative Diseases: Pathogenic Antibodies or Promising Biomarkers for Diagnosis.Antibodies (Basel, Switzerland) · 2023Review
- Therapies for Tau-associated neurodegenerative disorders: targeting molecules, synapses, and cells.Neural regeneration research · 2023Article
- Computational identification of HCV neutralizing antibodies with a common HCDR3 disulfide bond motif in the antibody repertoires of infected individuals.Nature communications · 2022Review
- Immune Response at the Crossroads of Atherosclerosis and Alzheimer's Disease.Frontiers in cardiovascular medicine · 2022Review
- Autoantibodies in neurological disease.Nature reviews. Immunology · 2021Review
- Therapeutic Ultrasound as a Treatment Modality for Physiological and Pathological Ageing Including Alzheimer's Disease.Pharmaceutics · 2021Review
- Mechanisms of Regulation and Diverse Activities of Tau-Tubulin Kinase (TTBK) Isoforms.Cellular and molecular neurobiology · 2021Article
- High-specificity antibodies and detection methods for quantifying phosphorylated tau from clinical samples.Antibody therapeutics · 2021Review
- Solid-state NMR investigation of the involvement of the P2 region in tau amyloid fibrils.Scientific reports · 2020Article
- Tauopathies: Deciphering Disease Mechanisms to Develop Effective Therapies.International journal of molecular sciences · 2020Review
- Autoantibodies against the prion protein in individuals withNeurology · 2020Article
- Acute inhibition of the CNS-specific kinase TTBK1 significantly lowers tau phosphorylation at several disease relevant sites.PloS one · 2020Article
- B cells in autoimmune and neurodegenerative central nervous system diseases.Nature reviews. Neuroscience · 2019Review
- Widespread Tau-Specific CD4 T Cell Reactivity in the General Population.Journal of immunology (Baltimore, Md. : 1950) · 2019Article
- Naturally occurring antibodies isolated from PD patients inhibit synuclein seeding in vitro and recognize Lewy pathology.Acta neuropathologica · 2019Article
- CX3CR1-deficient microglia shows impaired signalling of the transcription factor NRF2: Implications in tauopathies.Redox biology · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
36 authors at 6 institutions in 3 countries.
Gabriel PascualJanssen Prevention Center, Janssen Pharmaceutical Companies of Johnson & Johnson, 3210, Merryfield Row, San Diego, CA, 92121, USA.
Jehangir S WadiaJanssen Prevention Center, Janssen Pharmaceutical Companies of Johnson & Johnson, 3210, Merryfield Row, San Diego, CA, 92121, USA.
Xueyong ZhuDepartment of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, 92037, USA.
Elissa KeoghJanssen Prevention Center, Janssen Pharmaceutical Companies of Johnson & Johnson, 3210, Merryfield Row, San Diego, CA, 92121, USA.
Başak KükrerJanssen Prevention Center, Janssen Pharmaceutical Companies of Johnson & Johnson, Archimedesweg 6, 2333 CN, Leiden, The Netherlands.
Jeroen van AmeijdeJanssen Prevention Center, Janssen Pharmaceutical Companies of Johnson & Johnson, Archimedesweg 6, 2333 CN, Leiden, The Netherlands.
Hanna InganäsJanssen Prevention Center, Janssen Pharmaceutical Companies of Johnson & Johnson, Archimedesweg 6, 2333 CN, Leiden, The Netherlands.
Berdien SiregarJanssen Prevention Center, Janssen Pharmaceutical Companies of Johnson & Johnson, Archimedesweg 6, 2333 CN, Leiden, The Netherlands.
Gerrard PerdokJanssen Prevention Center, Janssen Pharmaceutical Companies of Johnson & Johnson, Archimedesweg 6, 2333 CN, Leiden, The Netherlands.
Otto DiefenbachJanssen Prevention Center, Janssen Pharmaceutical Companies of Johnson & Johnson, Archimedesweg 6, 2333 CN, Leiden, The Netherlands.
Tariq NaharJanssen Prevention Center, Janssen Pharmaceutical Companies of Johnson & Johnson, Archimedesweg 6, 2333 CN, Leiden, The Netherlands.
Imke SprengersJanssen Prevention Center, Janssen Pharmaceutical Companies of Johnson & Johnson, Archimedesweg 6, 2333 CN, Leiden, The Netherlands.
Martin H KoldijkJanssen Prevention Center, Janssen Pharmaceutical Companies of Johnson & Johnson, Archimedesweg 6, 2333 CN, Leiden, The Netherlands.
Els C Brinkman-van der LindenJanssen Prevention Center, Janssen Pharmaceutical Companies of Johnson & Johnson, Archimedesweg 6, 2333 CN, Leiden, The Netherlands.
Laura A PeferoenDepartment of Pathology, Amsterdam Neuroscience, VU University Medical Center, De Boelelaan 1117, Amsterdam, 1081 HV, The Netherlands.
Heng ZhangDepartment of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, 92037, USA.
Wenli YuDepartment of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, 92037, USA.
Xinyi LiJanssen Prevention Center, Janssen Pharmaceutical Companies of Johnson & Johnson, 3210, Merryfield Row, San Diego, CA, 92121, USA.
Michelle WagnerJanssen Prevention Center, Janssen Pharmaceutical Companies of Johnson & Johnson, 3210, Merryfield Row, San Diego, CA, 92121, USA.
Veronica MorenoJanssen Prevention Center, Janssen Pharmaceutical Companies of Johnson & Johnson, 3210, Merryfield Row, San Diego, CA, 92121, USA.
Julie KimJanssen Prevention Center, Janssen Pharmaceutical Companies of Johnson & Johnson, 3210, Merryfield Row, San Diego, CA, 92121, USA.
Martha CostaJanssen Prevention Center, Janssen Pharmaceutical Companies of Johnson & Johnson, 3210, Merryfield Row, San Diego, CA, 92121, USA.
Kiana WestJanssen Prevention Center, Janssen Pharmaceutical Companies of Johnson & Johnson, 2 Royal College Street, London, NW1 0NH, UK.
Zara FultonJanssen Prevention Center, Janssen Pharmaceutical Companies of Johnson & Johnson, 3210, Merryfield Row, San Diego, CA, 92121, USA.
Lucy ChammasJanssen Prevention Center, Janssen Pharmaceutical Companies of Johnson & Johnson, 3210, Merryfield Row, San Diego, CA, 92121, USA.
Nancy LuckashenakJanssen Prevention Center, Janssen Pharmaceutical Companies of Johnson & Johnson, 3210, Merryfield Row, San Diego, CA, 92121, USA.
Lauren FletcherJanssen Prevention Center, Janssen Pharmaceutical Companies of Johnson & Johnson, 3210, Merryfield Row, San Diego, CA, 92121, USA.
Trevin HollandJanssen Prevention Center, Janssen Pharmaceutical Companies of Johnson & Johnson, 3210, Merryfield Row, San Diego, CA, 92121, USA.
Carrie ArnoldJanssen Prevention Center, Janssen Pharmaceutical Companies of Johnson & Johnson, 3210, Merryfield Row, San Diego, CA, 92121, USA.
R Anthony WilliamsonJanssen Prevention Center, Janssen Pharmaceutical Companies of Johnson & Johnson, 2 Royal College Street, London, NW1 0NH, UK.
Jeroen J HoozemansDepartment of Pathology, Amsterdam Neuroscience, VU University Medical Center, De Boelelaan 1117, Amsterdam, 1081 HV, The Netherlands.
Adrian ApetriJanssen Prevention Center, Janssen Pharmaceutical Companies of Johnson & Johnson, Archimedesweg 6, 2333 CN, Leiden, The Netherlands.
Frederique BardJanssen Prevention Center, Janssen Pharmaceutical Companies of Johnson & Johnson, 3210, Merryfield Row, San Diego, CA, 92121, USA.
Ian A WilsonDepartment of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, 92037, USA.
Wouter KoudstaalJanssen Prevention Center, Janssen Pharmaceutical Companies of Johnson & Johnson, Archimedesweg 6, 2333 CN, Leiden, The Netherlands. WKoudsta@its.jnj.com.ORCID 0000-0001-9845-9036
Jaap GoudsmitJanssen Prevention Center, Janssen Pharmaceutical Companies of Johnson & Johnson, Archimedesweg 6, 2333 CN, Leiden, The Netherlands.
Johnson & Johnson (United States) · USJanssen (Netherlands) · NLScripps Research Institute · USAmsterdam Neuroscience · NLJanssen (United Kingdom) · GBHarvard University · US
Funding
No grant is acknowledged in the PubMed record.
Abstract
Several reports have described the presence of antibodies against Alzheimer's disease-associated hyperphosphorylated forms of tau in serum of healthy individuals. To characterize the specificities that can be found, we interrogated peripheral IgG
Indexed as
AdolescentAdultAgedAlzheimer DiseaseAmino Acid SequenceAntibodies, MonoclonalBinding SitesEpitopesFemaleHumansImmunologic MemoryMaleMiddle AgedNeurofibrillary TanglesPhosphorylationtau ProteinsAntibodies, MonoclonalEpitopesMAPT protein, humantau ProteinsAlzheimer’s diseaseMemory B cellMonoclonal antibodyTau protein
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.