Evidence map›Paper›PMID 28341977›Full record

ArticleNeuroscience bulletin2017

Genetic Analysis of FBXO2, FBXO6, FBXO12, and FBXO41 Variants in Han Chinese Patients with Sporadic Parkinson's Disease.

Lamei Yuan, Zhi Song, Xiong Deng, Zhijian Yang, Yan Yang, Yi Guo, Hongwei Lu, Hao Deng

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuroscience bulletin, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 17 citations in OpenAlex.

  1. Review
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  8. Extended Study ofFrontiers in neurology · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Lamei YuanCenter for Experimental Medicine, The Third Xiangya Hospital, Central South University, Changsha, 410013, China.
Zhi SongDepartment of Neurology, The Third Xiangya Hospital, Central South University, Changsha, 410013, China.
Xiong DengCenter for Experimental Medicine, The Third Xiangya Hospital, Central South University, Changsha, 410013, China.
Zhijian YangCenter for Experimental Medicine, The Third Xiangya Hospital, Central South University, Changsha, 410013, China.
Yan YangDepartment of Neurology, The Third Xiangya Hospital, Central South University, Changsha, 410013, China.
Yi GuoDepartment of Medical Information, Information Security and Big Data Research Institute, Central South University, Changsha, 410013, China.
Hongwei LuCenter for Experimental Medicine, The Third Xiangya Hospital, Central South University, Changsha, 410013, China. hwlv2226@163.com.
Hao DengCenter for Experimental Medicine, The Third Xiangya Hospital, Central South University, Changsha, 410013, China. hdeng008@yahoo.com.
Central South University · CNThird Xiangya Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Parkinson's disease (PD) is the second most common neurodegenerative disorder and has an elusive etiology. It is likely multifactorial, and genetic defects contribute to its pathogenesis. At least 25 genetic loci and 20 monogenic genes have been identified in monogenic PD. Recessive F-box protein 7 gene (FBXO7) mutations reportedly cause hereditary parkinsonism. To explore the roles of four paralogs (FBXO2, FBXO6, FBXO12, and FBXO41) in PD development, their variants (rs9614, rs28924120, rs6442117, and rs61733550, respectively) were analyzed in 502 Han Chinese patients with PD and 556 age, gender, and ethnicity-matched normal participants in mainland China. Statistically significant differences in genotypic and allelic frequencies were detected only in the FBXO2 variant rs9614 (P = 0.001 and 0.023, respectively; odds ratio 0.819, 95% confidence interval 0.690-0.973) between patients and controls. These results suggest that the FBXO2 variant rs9614 C allele may decrease the PD risk in mainland Han Chinese and may be a biomarker for PD.

Indexed as

AgedAllelesAsian PeopleCase-Control StudiesEthnicityF-Box ProteinsFemaleGenetic Association StudiesGenetic Predisposition to DiseaseGenotypeHumansMaleMiddle AgedMutationParkinson DiseaseF-Box ProteinsFBXO12FBXO2FBXO41FBXO6Parkinson’s diseaseVariant

Identifiers

PMID28341977
PMCPMC5636729
OpenAlexW2600802980

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.