Evidence map›Paper›PMID 28341971›Full record

ArticleSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2017

A prospective, observational, multicenter study on risk factors and prophylaxis for low emetic risk chemotherapy-induced nausea and vomiting.

Toshinobu Hayashi, Mototsugu Shimokawa, Takanori Miyoshi, Yoko Toriyama, Chiaki Yokota, Jun Taniguchi, Kiyonori Hanada, Kyouichi Tsumagari, Noriko Okubo, Yoshimichi Koutake and 5 more

Abstract readMulticenter Study
PubMed Publisher
In one paragraph

Article in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 2 pooled it
0.7field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 2 syntheses or guidelines pooled it, 14 citations in OpenAlex.

  1. Outcomes of chemotherapy-induced nausea and vomiting guideline adherence in pediatric and adult patients: a systematic review.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024
    Pooled it
  2. Pooled it
  3. Observational
  4. Observational
  5. 2023 updated MASCC/ESMO consensus recommendations: controlling nausea and vomiting with chemotherapy of low or minimal emetic potential.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2023
    Article
  6. A retrospective study on chemotherapy-induced nausea and vomiting in highly/moderately emetogenic chemotherapy: incidence and prescribing practice.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2022
    Article
  7. Article
  8. Article
  9. Evaluation of Adherence to Antiemetic Treatment Guidelines in Patients With Chemotherapy-Induced Nausea and Vomiting in Teaching Hospitals in Tehran.Journal of cancer education : the official journal of the American Association for Cancer Education · 2021
    Observational
  10. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 8 institutions in 1 country.

Toshinobu HayashiDepartment of Pharmacy, Clinical Research Institute, National Kyushu Medical Center, 1-8-1, Jigyohama, Chuo-ku, Fukuoka, 810-8563, Japan. nenten-ph@umin.org.ORCID 0000-0001-6183-4939
Mototsugu ShimokawaCancer Biostatistics Laboratory, Clinical Research Institute, National Kyushu Cancer Center, 3-1-1, Notame, Minami-ku, Fukuoka, 811-1395, Japan.
Takanori MiyoshiDepartment of Pharmacy, National Hospital Organization Beppu Medical Center, 1473 Uchikamado, Beppu, Oita, 874-0011, Japan.
Yoko ToriyamaDepartment of Pharmacy, National Hospital Organization Beppu Medical Center, 1473 Uchikamado, Beppu, Oita, 874-0011, Japan.
Chiaki YokotaDepartment of Pharmacy, National Hospital Organization Nagasaki Medical Center, 2-1001-1 Kubara, Omura, Nagasaki, 856-8562, Japan.
Jun TaniguchiDepartment of Pharmacy, National Hospital Organization Ureshino Medical Center, 2436 Oazashimojukuhei, Ureshino-cho, Ureshino, Saga, 843-0393, Japan.
Kiyonori HanadaDepartment of Pharmacy, National Hospital Organization Kumamoto Saishunso National Hospital, 2659 Suya, Koushi, Kumamoto, 861-1196, Japan.
Kyouichi TsumagariDepartment of Pharmacy, National Hospital Organization Miyakonojo Medical Center, 5033-1 Iwayoshi-cho, Miyakonojo, Miyazaki, 885-0014, Japan.
Noriko OkuboDepartment of Pharmacy, National Hospital Organization Kumamoto Medical Center, 1-5 Ninomaru, Chuo-ku, Kumamoto, 860-0008, Japan.
Yoshimichi KoutakeDepartment of Pharmacy, National Hospital Organization Fukuoka National Hospital, 1-39-4, Yakatabaru, Minami-ku, Fukuoka, 811-1394, Japan.
Kohei SakataDepartment of Pharmacy, National Hospital Organization Kumamoto South National Hospital, 2338 Toyofuku, Matsubase-cho, Uki, Kumamoto, 869-0593, Japan.
Yosei KawamataDepartment of Pharmacy, National Hospital Organization Kagoshima Medical Center, 8-1, Shiroyama-cho, Kagoshima, 892-0853, Japan.
Takashi GotoDepartment of Pharmacy, National Hospital Organization Kokura Medical Center, 10-1, Harugaoka, Kokuraminami-ku, Kitakyushu, 802-8533, Japan.
Yasufumi TsurusakiDepartment of Pharmacy, National Hospital Organization Saga National Hospital, 1-20-1, Hinode, Saga, 849-8577, Japan.
Makiko KoyabuDepartment of Pharmacy, Clinical Research Institute, National Kyushu Medical Center, 1-8-1, Jigyohama, Chuo-ku, Fukuoka, 810-8563, Japan.
National Hospital Organization · JPBeppu Medical Center · JPKumamoto Medical Center · JPNational Kyushu Medical Center · JPFukuoka Hospital · JPNagasaki Medical Center · JPNational Hospital Organization Kyushu Cancer Center · JPNational Sagamihara Hospital · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThe incidence of and the risk factors for nausea and vomiting in patients undergoing low emetic risk chemotherapy (LEC) are unclear. The aim of the study was to provide information on these topics by performing a multicenter, observational, prospective study.

methodsThe study consisted of patients who were administered first-time LEC that was consistent or inconsistent with current guidelines. Using the visual analog scale, patients recorded their daily food intake and the occurrence and severity of nausea over a 5-day treatment period.

resultsThe overall incidence of chemotherapy-induced nausea and vomiting did not differ significantly between patients undergoing guideline-consistent (n = 89) or guideline-inconsistent (n = 121) prophylaxis (30.3 vs. 22.3%, respectively; P = 0.19). Logistic regression analysis identified a history of nausea and LEC other than taxanes as independent risk factors associated with nausea and vomiting in patients undergoing LEC. The mean daily visual analog scale scores for nausea severity and a decrease in food intake were <25 mm throughout the entire observation period.

conclusionsGuideline-consistent prophylaxis appeared to control nausea and vomiting effectively in patients undergoing LEC. However, patients with a history of nausea and receiving LEC other than taxanes should be carefully observed and treatment should be adjusted according to their symptoms.

Indexed as

AgedAntiemeticsAntineoplastic AgentsFemaleHumansMaleMiddle AgedNauseaProspective StudiesRisk FactorsVomitingAntiemeticsAntineoplastic AgentsChemotherapy-induced nausea and vomitingLow emetic risk chemotherapyNauseaRisk factorsVomiting

Identifiers

PMID28341971
OpenAlexW2602916347

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.