ReviewPain and therapy2017
The Basic Pharmacology of Opioids Informs the Opioid Discourse about Misuse and Abuse: A Review.
Review in Pain and therapy, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 52 citations in OpenAlex.
- Opioids to Treat Chronic Pain in the Older Adult: A Clinical Consensus to Guarantee Safety and Avoid Adverse Events.Drugs & aging · 2026Review
- Novel Synthetic Opioids (NSOs) and Their Evolving Crisis: Utilising NPSPharmaceuticals (Basel, Switzerland) · 2025Article
- Concomitant medication effects on patients with lung cancer taking immune checkpoint inhibitors a review.Medical oncology (Northwood, London, England) · 2025Review
- Postmarketing Research for Opioid Abuse-Deterrent Formulations: A Narrative Review.Journal of pain research · 2025Review
- Association between opioids use and risk of multiple cancers: A two-sample Mendelian randomization study.Journal of anesthesia and translational medicine · 2024Article
- Opium alkaloids, biosynthesis, pharmacology and association with cancer occurrence.Open biology · 2023Review
- Plasma pharmacokinetics and pharmacodynamic effects of the 2-benzylbenzimidazole synthetic opioid, isotonitazene, in male rats.Psychopharmacology · 2023Article
- Review
- Detection of vaping, cannabis use, and hazardous prescription opioid use among adolescents.The Lancet. Child & adolescent health · 2022Review
- Pharmacogenetics: A Precision Medicine Approach to Combatting the Opioid Epidemic.Journal of the American College of Clinical Pharmacy : JACCP · 2022Article
- 10-Dehydrogingerdione Attenuates Tramadol-Induced Nephrotoxicity by Modulating Renal Oxidative Stress, Inflammation and Apoptosis in Experimental Rats: Role of HO-1 Activation and TLR4/NF-κB/ERK Inhibition.International journal of molecular sciences · 2022Article
- The patterns and burden of multimorbidity in geriatric patients with prolonged use of addictive medications.Aging clinical and experimental research · 2021Article
- The Implementation of an Acute Pain Service for Patients Undergoing Open Ventral Hernia Repair with Mesh and Abdominal Wall Reconstruction.World journal of surgery · 2021Article
- Analgesic purchases among older adults - a population-based study.BMC public health · 2021Article
- Opioid Management: Initiating, Monitoring, and Tapering.Physical medicine and rehabilitation clinics of North America · 2020Review
- Opioid Prescribing Among Adults With Disabilities in the United States After the 2014 Federal Hydrocodone Rescheduling Regulation.Public health reports (Washington, D.C. : 1974) · 2020Article
- A Quantitative and Narrative Evaluation of Goodman and Gilman's Pharmacological Basis of Therapeutics.Pharmacy (Basel, Switzerland) · 2019Article
- Anticholinergic medicines use among older adults before and after initiating dementia medicines.British journal of clinical pharmacology · 2019Article
- Core Outcome Measures in Preclinical Assessment of Candidate Analgesics.Pharmacological reviews · 2019Review
- The double opioid crisis: A call for balance.Pharmacoepidemiology and drug safety · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Morphine and other opioids are widely used to manage moderate to severe acute pain syndromes, such as pain associated with trauma or postoperative pain, and they have been used to manage chronic pain, even chronic nonmalignant pain. However, recent years have seen a renewed recognition of the potential for overuse, misuse, and abuse of opioids. Therefore, prescribing opioids is challenging for healthcare providers in that clinical effectiveness must be balanced against negative outcomes-with the possibility that neither are achieved perfectly. The current discourse about the dual 'epidemics' of under-treatment of legitimate pain and the over-prescription of opioids is clouded by inadequate or inaccurate understanding of opioid drugs and the endogenous pain pathways with which they interact. An understanding of the basic pharmacology of opioids helps inform the clinician and other stakeholders about these simultaneously under- and over-used agents.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.