Evidence map›Paper›PMID 28341925›Full record

ArticleSleep & breathing = Schlaf & Atmung2017

Relationship between serum adiponectin and bone mineral density in male patients with obstructive sleep apnea syndrome.

Dong-Dong Chen, Jie-Feng Huang, Qi-Chang Lin, Gong-Ping Chen, Jian-Ming Zhao

Abstract read
PubMed Publisher
In one paragraph

Article in Sleep & breathing = Schlaf & Atmung, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 4 pooled it
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 4 syntheses or guidelines pooled it, 23 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Review
  12. Review
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Dong-Dong ChenDepartment of Respiratory Medicine, Fujian Provincial Sleep-disordered Breathing Clinic Center, Laboratory of Respiratory Disease, The First Affiliated Hospital of Fujian Medical University, NO 20, Chazhong Road, Taijiang District, Fuzhou, Fujian Province, People's Republic of China, 350005.
Jie-Feng HuangDepartment of Respiratory Medicine, Fujian Provincial Sleep-disordered Breathing Clinic Center, Laboratory of Respiratory Disease, The First Affiliated Hospital of Fujian Medical University, NO 20, Chazhong Road, Taijiang District, Fuzhou, Fujian Province, People's Republic of China, 350005.
Qi-Chang LinDepartment of Respiratory Medicine, Fujian Provincial Sleep-disordered Breathing Clinic Center, Laboratory of Respiratory Disease, The First Affiliated Hospital of Fujian Medical University, NO 20, Chazhong Road, Taijiang District, Fuzhou, Fujian Province, People's Republic of China, 350005. chang4e@126.com.
Gong-Ping ChenDepartment of Respiratory Medicine, Fujian Provincial Sleep-disordered Breathing Clinic Center, Laboratory of Respiratory Disease, The First Affiliated Hospital of Fujian Medical University, NO 20, Chazhong Road, Taijiang District, Fuzhou, Fujian Province, People's Republic of China, 350005.
Jian-Ming ZhaoDepartment of Respiratory Medicine, Fujian Provincial Sleep-disordered Breathing Clinic Center, Laboratory of Respiratory Disease, The First Affiliated Hospital of Fujian Medical University, NO 20, Chazhong Road, Taijiang District, Fuzhou, Fujian Province, People's Republic of China, 350005.
First Affiliated Hospital of Fujian Medical University · CNFujian Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeObstructive sleep apnea syndrome (OSAS) is reported to have an association with bone mineral density (BMD). However, the underlying mechanism is far from clear. The aim of this study was to investigate the relationship between OSAS, bone turnover markers, and BMD and to evaluate the effect of adiponectin on BMD in patients with OSAS.

methodsSeventy-one male patients with OSAS and 13 male control subjects were enrolled in this study. Serum adiponectin, calcium, phosphorus, 25-hydroxyvitamin-D3, β-isomerized form C-terminal telopeptide of type I collagen, osteocalcin, and procollagen type 1 N-propeptide were measured in all subjects, and BMD was evaluated by dual-energy X-ray absorptiometry (DEXA) in the lumbar spine (L1-L4), the femoral neck, and the hip total.

resultsNo statistically significant differences were found between the studied groups in terms of demographic data and bone turnover markers. Serum adiponectin significantly decreased with the aggravation of OSAS. Compared with subjects without OSAS, those with OSAS had a higher hip total BMD and t scores (p = 0.027 and p = 0.028). The significant negative association was found between serum adiponectin levels and hip total BMD. After adjusting for confounders, adiponectin as well as oxygen desaturation index (ODI) significantly predicted the hip total BMD (β = -0.232, p = 0.005 and β = 0.226, p = 0.037).

conclusionsIn male subjects, the presence of obstructive sleep apnea syndrome is associated with higher bone mineral density of the hip. These findings suggest that serum adiponectin may be an underlying mediator for BMD in OSAS.

Indexed as

Absorptiometry, PhotonAdiponectinAdultBone DensityBone RemodelingHumansMaleMiddle AgedReference ValuesSleep Apnea, ObstructiveStatistics as TopicAdiponectinAdiponectinBone mineral densityBone turnover markersObstructive sleep apnea syndrome

Identifiers

PMID28341925
OpenAlexW2598968095

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.