ArticleBrain imaging and behavior2018
Childhood adversity associated with white matter alteration in the corpus callosum, corona radiata, and uncinate fasciculus of psychiatrically healthy adults.
Abstract read
In one paragraph
Article in Brain imaging and behavior, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 3 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed, 3 pooled it
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
38 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- White Matter Tract Alterations in Bipolar Disorder: A Systematic Review and Meta-Analysis of Diffusion Tensor Imaging Studies.Brain and behavior · 2026Pooled it
- Early life adversity and white matter microstructural organization-a systematic review.Brain imaging and behavior · 2025Pooled it
- BDNF Genetic Variant and Its Genotypic Fluctuation in Major Depressive Disorder.Behavioural neurology · 2021Pooled it
- Alexithymia mediates white-matter microstructure and substance use escalation in trauma-exposed individuals.Journal of affective disorders · 2026Article
- Childhood Trauma and Frontoparietal Network Connectivity During Working Memory Task Performance in Individuals With Schizophrenia and Healthy Participants.The European journal of neuroscience · 2026Article
- Adversity as the key feature: neuroimaging profiles of subtypes from multiple depression risk factors.Psychological medicine · 2026Article
- White matter reflects the childhood exposome.bioRxiv : the preprint server for biology · 2026Article
- Corticolimbic structure-function coupling is sensitive to childhood adversity and buffers adversity-related symptoms during development.bioRxiv : the preprint server for biology · 2025Article
- Family History of Substance Use and Stressful Life Events Impact Adolescent Maturation of Cerebral White Matter.Addiction biology · 2025Article
- Risky family environment, white matter organization, and effective parenting in expectant fathers.Development and psychopathology · 2025Article
- Adverse childhood experiences influence markers of neurodegeneration risk in older adults.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Whole-brain white matter variation across childhood environments.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- The Journey of the Default Mode Network: Development, Function, and Impact on Mental Health.Biology · 2025Review
- Annual Research Review: Neuroimmune network model of depression: a developmental perspective.Journal of child psychology and psychiatry, and allied disciplines · 2024Review
- Making Connections: Neurodevelopmental Changes in Brain Connectivity After Adverse Experiences in Early Adolescence.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Alterations in the white matter structure of major depressive disorder patients and their link to childhood trauma.Frontiers in psychiatry · 2024Article
- Impact of Childhood Trauma Exposure, Genetic Variation in Endocannabinoid Signaling, and Anxiety on Frontolimbic Pathways in Children.Cannabis and cannabinoid research · 2023Article
- Shared and distinct structural brain networks related to childhood maltreatment and social support: connectome-based predictive modeling.Molecular psychiatry · 2023Article
- Characteristics of white matter structural connectivity in healthy adults with childhood maltreatment.European journal of psychotraumatology · 2023Article
- Associations of maternal emotion regulation with child white matter connectivity in Black American mother-child dyads.Developmental psychobiology · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Simon McCarthy-JonesDepartment of Psychiatry, School of Medicine, and Trinity College Institute of Neuroscience, Trinity College Dublin, Dublin, 8, Ireland. s.mccarthyjones@gmail.com.ORCID http://orcid.org/0000-0003-4442-7818
Lena K L OestreichSchool of Psychology, University of New South Wales, Sydney, NSW, Australia.
Amanda E LyallDepartment of Psychiatry, Psychiatry Neuroimaging Laboratory, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Zora KikinisDepartment of Psychiatry, Psychiatry Neuroimaging Laboratory, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Dominick T NewellDepartment of Psychiatry, Psychiatry Neuroimaging Laboratory, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Peter SavadjievDepartment of Psychiatry, Psychiatry Neuroimaging Laboratory, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Martha E ShentonDepartment of Psychiatry, Psychiatry Neuroimaging Laboratory, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Marek KubickiDepartment of Psychiatry, Psychiatry Neuroimaging Laboratory, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Ofer PasternakDepartment of Psychiatry, Psychiatry Neuroimaging Laboratory, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Thomas J WhitfordSchool of Psychology, University of New South Wales, Sydney, NSW, Australia.
Australian Schizophrenia Research Bank
Funding
Training and DisseminationP41EB015902 · NIBIB · BRIGHAM AND WOMEN'S HOSPITAL · PI PUJOL, SONIA · 2012 to 2022
$20.9MNovel DT-MRI Analyses of White Matter in SchizophreniaR01MH074794 · NIMH · BRIGHAM AND WOMEN'S HOSPITAL · PI WESTIN, CARL-FREDRIK · 2007 to 2021
$9.6MStuart T. Hauser Research Training Program in Biological and Social Psychiatry.T32MH016259 · NIMH · JUDGE BAKER CHILDREN'S CENTER · PI Marek Kubicki, Martha E. Shenton · 1985 to 2026
$8.4MNeural substrates of diffusion imaging in cognitively aging rhesus monkeysR01AG042512 · NIA · BRIGHAM AND WOMEN'S HOSPITAL · PI KUBICKI, MAREK, MAKRIS, NIKOLAOS · 2013 to 2023
$6.5MMechanisms of myelin damage and cognitive impairment in the aging monkey: Gene Expression, Neurophysiology, Inflammation and Effects of Calorie RestrictionRF1AG043640 · NIA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI ROSENE, DOUGLAS L · 2019 to 2019
$3.7MHistopathology, Neuroimaging and Mechanism of Myelin Damage in Aging Monkey BrainR01AG043640 · NIA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI ROSENE, DOUGLAS L · 2013 to 2017
$3.0MDiffusion Imaging Biomarkers for Risk, Onset and Outcome in SchizophreniaR01MH102377 · NIMH · BRIGHAM AND WOMEN'S HOSPITAL · PI KUBICKI, MAREK · 2014 to 2018
$2.8MNext Generation Diffusion MRI Biomarkers for Prodromal SchizophreniaR01MH108574 · NIMH · BRIGHAM AND WOMEN'S HOSPITAL · PI PASTERNAK, OFER · 2016 to 2020
$2.2MMentoring and Neuroimaging Research on White Matter Pathology in SchizophreniaK24MH110807 · NIMH · BRIGHAM AND WOMEN'S HOSPITAL · PI KUBICKI, MAREK · 2017 to 2021
$945kAustralian Research Council DE140101077Australian Research Council DP140104394National Alliance for Research on Schizophrenia and Depression 22591NIA NIH HHS R01 AG042512NIA NIH HHS R01 AG043640NIA NIH HHS RF1 AG043640NIBIB NIH HHS P41 EB015902NIH HHS P41EB015902NIH HHS R01AG04252NIH HHS R01MH074794NIH HHS R01MH102377NIH HHS RO1MH108574NIH HHS T32MH016259NIMH NIH HHS K24 MH110807NIMH NIH HHS R01 MH074794NIMH NIH HHS R01 MH102377NIMH NIH HHS R01 MH108574NIMH NIH HHS T32 MH016259
Abstract
Diffusion tensor imaging studies report childhood adversity (CA) is associated with reduced fractional anisotropy (FA) in multiple white matter tracts in adults. Reduced FA may result from changes in tissue, suggesting myelin/axonal damage, and/or from increased levels of extracellular free-water, suggesting atrophy or neuroinflammation. Free-water imaging can separately identify FA in tissue (FA
Indexed as
Adult Survivors of Child Adverse EventsDiffusion Tensor ImagingAdultCorpus CallosumFemaleHumansMaleNeural PathwaysStress, PsychologicalWhite MatterAbuseDiffusion tensor imagingFree-waterTrauma
Identifiers
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.