ArticleScientific reports2017
X-ray Dark-field Radiography - In-Vivo Diagnosis of Lung Cancer in Mice.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 86 citations in OpenAlex.
- Feasibility of longitudinal in vivo monitoring of pulmonary disease progression in mouse models using laboratory-based x-ray dark-field CT.European radiology experimental · 2026Article
- Moiré artifact reduction in grating interferometry using multiple harmonics and total variation regularization.Scientific reports · 2026Article
- Beam-hardening correction in clinical x-ray dark-field chest radiography using deep-learning-based bone segmentation.Medical physics · 2026Article
- Advanced X-Ray Imaging Technology.Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer · 2026Review
- Dark-field chest radiography signal characteristics in inspiration and expiration in healthy and emphysematous subjects.European radiology experimental · 2025Article
- Grating-based x-ray dark-field CT for lung cancer diagnosis in mice.European radiology experimental · 2024Article
- Article
- Comparison of dark-field chest radiography and CT for the assessment of COVID-19 pneumonia.Frontiers in radiology · 2024Article
- Laboratory-based x-ray dark-field microscopy.Physical review applied · 2023Article
- On the quantification of sample microstructure using single-exposure x-ray dark-field imaging via a single-grid setup.Scientific reports · 2023Article
- Dark-field chest X-ray imaging for the assessment of COVID-19-pneumonia.Communications medicine · 2022Article
- Dark-field chest x-ray imaging: first experience in patients with alpha1-antitrypsin deficiency.European radiology experimental · 2022Article
- Dark-field computed tomography reaches the human scale.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- X-ray dark-field chest imaging for detection and quantification of emphysema in patients with chronic obstructive pulmonary disease: a diagnostic accuracy study.The Lancet. Digital health · 2021Article
- In-vivo X-ray dark-field computed tomography for the detection of radiation-induced lung damage in mice.Physics and imaging in radiation oncology · 2021Article
- X-ray dark-field radiography for in situ gout diagnosis by means of an ex vivo animal study.Scientific reports · 2021Article
- High-resolution multicontrast tomography with an X-ray microarray anode-structured target source.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Whole-body x-ray dark-field radiography of a human cadaver.European radiology experimental · 2021Article
- Next-Generation Hardware Advances in CT: Cardiac Applications.Radiology · 2021Review
- A proof-of principal study using phase-contrast imaging for the detection of large airway pathologies after lung transplantation.Scientific reports · 2020Article
Corrections and comments
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Authors and funding
13 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Accounting for about 1.5 million deaths annually, lung cancer is the prevailing cause of cancer deaths worldwide, mostly associated with long-term smoking effects. Numerous small-animal studies are performed currently in order to better understand the pathogenesis of the disease and to develop treatment strategies. Within this letter, we propose to exploit X-ray dark-field imaging as a novel diagnostic tool for the detection of lung cancer on projection radiographs. Here, we demonstrate in living mice bearing lung tumors, that X-ray dark-field radiography provides significantly improved lung tumor detection rates without increasing the number of false-positives, especially in the case of small and superimposed nodules, when compared to conventional absorption-based imaging. While this method still needs to be adapted to larger mammals and finally humans, the technique presented here can already serve as a valuable tool in evaluating novel lung cancer therapies, tested in mice and other small animal models.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.