ArticleGenome research2017
Small chromosomal regions position themselves autonomously according to their chromatin class.
Article in Genome research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed.
- CENP-A and centromere evolution in equids.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2025Review
- Structural insights into p300 regulation and acetylation-dependent genome organisation.Nature communications · 2022Article
- Molecular Dynamics and Evolution of Centromeres in the Genus Equus.International journal of molecular sciences · 2022Review
- An RNA Polymerase III General Transcription Factor Engages in Cell Type-Specific Chromatin Looping.International journal of molecular sciences · 2022Article
- Review
- Chromatin Organization and Function inCells · 2021Review
- Homotypic clustering of L1 and B1/Alu repeats compartmentalizes the 3D genome.Cell research · 2021Article
- Viewing Nuclear Architecture through the Eyes of Nocturnal Mammals.Trends in cell biology · 2020Review
- TFIIIC Binding to Alu Elements Controls Gene Expression via Chromatin Looping and Histone Acetylation.Molecular cell · 2020Article
- Exploring trophoblast-specific Tead4 enhancers through chromatin conformation capture assays followed by functional screening.Nucleic acids research · 2020Article
- Article
- Computational methods for analyzing and modeling genome structure and organization.Wiley interdisciplinary reviews. Systems biology and medicine · 2019Review
- Forces driving the three-dimensional folding of eukaryotic genomes.Molecular systems biology · 2018Review
- Birth, evolution, and transmission of satellite-free mammalian centromeric domains.Genome research · 2018Article
- Article
- Genetic and epigenetic variation in 5S ribosomal RNA genes reveals genome dynamics in Arabidopsis thaliana.Nucleic acids research · 2018Article
- Bacterial artificial chromosomes establish replication timing and sub-nuclear compartment de novo as extra-chromosomal vectors.Nucleic acids research · 2018Article
- Mouse chromocenters DNA content: sequencing and in silico analysis.BMC genomics · 2018Article
- Chromatin loops and causality loops: the influence of RNA upon spatial nuclear architecture.Chromosoma · 2017Review
Corrections and comments
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Authors and funding
18 authors.
Funding
Abstract
The spatial arrangement of chromatin is linked to the regulation of nuclear processes. One striking aspect of nuclear organization is the spatial segregation of heterochromatic and euchromatic domains. The mechanisms of this chromatin segregation are still poorly understood. In this work, we investigated the link between the primary genomic sequence and chromatin domains. We analyzed the spatial intranuclear arrangement of a human artificial chromosome (HAC) in a xenospecific mouse background in comparison to an orthologous region of native mouse chromosome. The two orthologous regions include segments that can be assigned to three major chromatin classes according to their gene abundance and repeat repertoire: (1) gene-rich and SINE-rich euchromatin; (2) gene-poor and LINE/LTR-rich heterochromatin; and (3) gene-depleted and satellite DNA-containing constitutive heterochromatin. We show, using fluorescence in situ hybridization (FISH) and 4C-seq technologies, that chromatin segments ranging from 0.6 to 3 Mb cluster with segments of the same chromatin class. As a consequence, the chromatin segments acquire corresponding positions in the nucleus irrespective of their chromosomal context, thereby strongly suggesting that this is their autonomous property. Interactions with the nuclear lamina, although largely retained in the HAC, reveal less autonomy. Taken together, our results suggest that building of a functional nucleus is largely a self-organizing process based on mutual recognition of chromosome segments belonging to the major chromatin classes.
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Registered trials
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