Evidence map›Paper›PMID 28341747›Full record

ArticleGut2018

Gut symbiotic microbes imprint intestinal immune cells with the innate receptor SLAMF4 which contributes to gut immune protection against enteric pathogens.

Allison Cabinian, Daniel Sinsimer, May Tang, Youngsoon Jang, Bongkum Choi, Yasmina Laouar, Amale Laouar

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Gut, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 32 citations in OpenAlex.

  1. Article
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  3. Vitamin BMicrobiome · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Allison CabinianThe Child Health Institute of New Jersey, Robert Wood Johnson Medical School, Rutgers University, New Brunswick, New Jersey, USA.
Daniel SinsimerThe Child Health Institute of New Jersey, Robert Wood Johnson Medical School, Rutgers University, New Brunswick, New Jersey, USA.
May TangThe Child Health Institute of New Jersey, Robert Wood Johnson Medical School, Rutgers University, New Brunswick, New Jersey, USA.
Youngsoon JangDepartment of Microbiology and Immunology, University of Michigan School of Medicine, Ann Arbor, Michigan, USA.
Bongkum ChoiDepartment of Microbiology and Immunology, University of Michigan School of Medicine, Ann Arbor, Michigan, USA.
Yasmina LaouarDepartment of Microbiology and Immunology, University of Michigan School of Medicine, Ann Arbor, Michigan, USA.
Amale LaouarThe Child Health Institute of New Jersey, Robert Wood Johnson Medical School, Rutgers University, New Brunswick, New Jersey, USA.
Rutgers, The State University of New Jersey · USUniversity of Michigan–Ann Arbor · US

Funding

Cellular and molecular mechanisms of NK cell suppressionR01AI083642 · NIAID · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI LAOUAR, YASMINA · 2011 to 2015
$1.7M
NIAID NIH HHS R01 AI083642
6 · The paper itself

Abstract

backgroundInteractions between host immune cells and gut microbiota are crucial for the integrity and function of the intestine. How these interactions regulate immune cell responses in the intestine remains a major gap in the field.

aimWe have identified the signalling lymphocyte activation molecule family member 4 (SLAMF4) as an immunomodulator of the intestinal immunity. The aim is to determine how SLAMF4 is acquired in the gut and what its contribution to intestinal immunity is.

methodsExpression of SLAMF4 was assessed in mice and humans. The mechanism of induction was studied using GFP

resultsSLAMF4 is a selective marker of intestinal immune cells of mice and humans. SLAMF4 induction occurs directly in the intestinal mucosa without the involvement of the gut-associated lymphoid tissue. Gut bacterial products, particularly those of gut anaerobes, and gut-resident antigen-presenting cell (APC)

conclusionsSLAMF4 is a marker of intestinal immune cells which contributes to the protection against enteric pathogens and whose expression is dependent on the presence of the gut microbiota. This discovery provides a possible mechanism for answering the long-standing question of how the intertwining of the host and gut microbial biology regulates immune cell responses in the gut.

Indexed as

AnimalsFlow CytometryGastrointestinal MicrobiomeGerm-Free LifeHumansImmunity, MucosalIntestinal MucosaMiceMice, Inbred C57BLReal-Time Polymerase Chain ReactionSignaling Lymphocytic Activation Molecule FamilySignal TransductionSymbiosisCd244a protein, mouseCD244 protein, humanSignaling Lymphocytic Activation Molecule FamilyANTIBIOTICSENTERIC INFECTIONSGASTROINTESTINAL IMMUNE RESPONSEINTESTINAL BACTERIAMUCOSAL IMMUNITY

Identifiers

PMID28341747
PMCPMC5890651
OpenAlexW2599082900

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.