Evidence map›Paper›PMID 28341733›Full record

ArticleHaematologica2017

Effect of antithymocyte globulin source on outcomes of bone marrow transplantation for severe aplastic anemia.

Natasha Kekre, Ying Zhang, Mei-Jie Zhang, Jeanette Carreras, Parvez Ahmed, Paolo Anderlini, Elias Hallack Atta, Mouhab Ayas, Jaap Jan Boelens, Carmem Bonfim and 7 more

Open access · goldAbstract read
In one paragraph

Article in Haematologica, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
3.9field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 50 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Review
  6. Review
  7. Review
  8. Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Anti-thymocyte globulin in haematology: Recent developments.The Indian journal of medical research · 2019
    Review
  14. Article
  15. Eculizumab Bridging before Bone Marrow Transplant for Marrow Failure Disorders Is Safe and Does Not Limit Engraftment.Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation · 2018
    Article
  16. Alternative donor transplants for severe aplastic anemia.Hematology. American Society of Hematology. Education Program · 2018
    Review
  17. Aplastic Anemia.The New England journal of medicine · 2018
    Review
  18. Review
  19. Article
  20. Diagnosis and Treatment of Aplastic Anemia.Current treatment options in oncology · 2017
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

17 authors at 13 institutions in 7 countries.

Natasha KekreDivision of Hematology, The Ottawa Hospital, ON, Canada.
Ying ZhangDivision of Biostatistics, Institute for Health and Society, Medical College of Wisconsin, Milwaukee, WI, USA.
Mei-Jie ZhangDivision of Biostatistics, Institute for Health and Society, Medical College of Wisconsin, Milwaukee, WI, USA.
Jeanette CarrerasCenter for International Blood and Marrow Transplant Research, Department of Medicine, Medical College of Wisconsin, Milwaukee, WI, USA.
Parvez AhmedArmed Forces Bone Marrow Transplant Center, Rawalpindi, Pakistan.
Paolo AnderliniDepartment of Stem Cell Transplantation and Cellular Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Elias Hallack AttaInstituto Nacional de Câncer, Rio de Janeiro, Brazil.
Mouhab AyasDepartment of Pediatric Hematology/Oncology, King Faisal Specialist Hospital & Research Center, Riyadh, Saudi Arabia.
Jaap Jan BoelensDepartment of Pediatrics, University Medical Center Utrecht, The Netherlands.
Carmem BonfimHospital de Clinicas, Federal University of Parana, Curitiba, Brazil.
H Joachim DeegClinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Neena KapoorDivision of Hematology, Oncology and Blood & Marrow Transplantation, Children's Hospital Los Angeles, CA, USA.
Jong-Wook LeeBMT Center, Seoul St. Mary's Hospital, The Catholic University of Korea, Seoul, South Korea.
Ryotaro NakamuraDepartment of Hematology & Hematopoietic Cell Transplantation, City of Hope, Duarte, CA, USA.
Michael A PulsipherDivision of Hematology, Oncology and Blood & Marrow Transplantation, Children's Hospital Los Angeles, CA, USA.
Mary EapenCenter for International Blood and Marrow Transplant Research, Department of Medicine, Medical College of Wisconsin, Milwaukee, WI, USA meapen@mcw.edu.
Joseph H AntinDivision of Hematologic Malignancies, Dana-Farber Cancer Institute, Boston, MA, USA.
Medical College of Wisconsin · USChildren's Hospital of Los Angeles · USArmed Forces Institute of Pathology · PKCity of Hope · USDana-Farber Cancer Institute · USFred Hutch Cancer Center · USInstituto Nacional do Câncer · BRKing Faisal Specialist Hospital & Research Centre · SAOttawa Hospital · CASeoul St. Mary's Hospital · KRThe University of Texas MD Anderson Cancer Center · USUniversidade Federal do Paraná · BRUniversity Medical Center Utrecht · NL

Funding

Data Resource for Analyzing Blood &Marrow TransplantsU24CA076518 · NCI · MEDICAL COLLEGE OF WISCONSIN · PI Amy M Moskop, Bronwen Shaw · 1998 to 2026
$105.2M
NCI NIH HHS U24 CA076518
6 · The paper itself

Abstract

For treatment of severe aplastic anemia, immunosuppressive therapy with horse antithymocyte globulin results in superior response and survival compared with rabbit antithymocyte globulin. This relative benefit may be different in the setting of transplantation as rabbit antithymocyte globulin results in more profound immunosuppression. We analyzed 833 severe aplastic anemia transplants between 2008 and 2013 using human leukocyte antigen (HLA)-matched siblings (n=546) or unrelated donors (n=287) who received antithymocyte globulin as part of their conditioning regimen and bone marrow graft. There were no differences in hematopoietic recovery by type of antithymocyte globulin. Among recipients of HLA-matched sibling transplants, day 100 incidence of acute (17%

Indexed as

Bone Marrow TransplantationAdolescentAdultAnemia, AplasticAntilymphocyte SerumComorbidityFemaleGraft vs Host DiseaseHistocompatibility TestingHumansInfectionsMaleMiddle AgedRisk FactorsSeverity of Illness IndexSiblingsAntilymphocyte Serum

Identifiers

PMID28341733
PMCPMC5566045
OpenAlexW2597657343

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.