Evidence map›Paper›PMID 28341696›Full record

ArticleDiabetes2017

A Low-Frequency Inactivating

Alisa Manning, Heather M Highland, Jessica Gasser, Xueling Sim, Taru Tukiainen, Pierre Fontanillas, Niels Grarup, Manuel A Rivas, Anubha Mahajan, Adam E Locke and 253 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Diabetes, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed, 3 pooled it
5.7field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 3 syntheses or guidelines pooled it, 51 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Review
  5. International journal of molecular sciences · 2026
    Article
  6. Review
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Insulin signaling and its application.Frontiers in endocrinology · 2023
    Review
  16. Article
  17. Review
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

263 authors at 20 institutions in 22 countries.

Alisa ManningProgram in Medical and Population Genetics, Broad Institute, Cambridge, MA.
Heather M HighlandHuman Genetics Center, The University of Texas MD Anderson Cancer Center and The University of Texas Health Science Center at Houston Graduate School of Biomedical Sciences, Houston, TX.
Jessica GasserProgram in Medical and Population Genetics, Broad Institute, Cambridge, MA.
Xueling SimDepartment of Biostatistics and Center for Statistical Genetics, School of Public Health, University of Michigan, Ann Arbor, MI.
Taru TukiainenProgram in Medical and Population Genetics, Broad Institute, Cambridge, MA.
Pierre FontanillasProgram in Medical and Population Genetics, Broad Institute, Cambridge, MA.
Niels GrarupThe Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Manuel A RivasWellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, U.K.
Anubha MahajanWellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, U.K.
Adam E LockeDepartment of Biostatistics and Center for Statistical Genetics, School of Public Health, University of Michigan, Ann Arbor, MI.
Pablo CingolaniSchool of Computer Science, McGill University, Montreal, Canada.
Tune H PersProgram in Medical and Population Genetics, Broad Institute, Cambridge, MA.
Ana ViñuelaDepartment of Twin Research & Genetic Epidemiology, King's College London, London, U.K.
Andrew A BrownWellcome Trust Sanger Institute, Hinxton, U.K.
Ying WuDepartment of Genetics, The University of North Carolina at Chapel Hill, Chapel Hill, NC.
Jason FlannickProgram in Medical and Population Genetics, Broad Institute, Cambridge, MA.
Christian FuchsbergerDepartment of Biostatistics and Center for Statistical Genetics, School of Public Health, University of Michigan, Ann Arbor, MI.
Eric R GamazonSection of Genetic Medicine, Department of Medicine, The University of Chicago, Chicago, IL.
Kyle J GaultonWellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, U.K.
Hae Kyung ImSection of Genetic Medicine, Department of Medicine, The University of Chicago, Chicago, IL.
Tanya M TeslovichDepartment of Biostatistics and Center for Statistical Genetics, School of Public Health, University of Michigan, Ann Arbor, MI.
Thomas W BlackwellDepartment of Biostatistics and Center for Statistical Genetics, School of Public Health, University of Michigan, Ann Arbor, MI.
Jette Bork-JensenThe Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Noël P BurttProgram in Medical and Population Genetics, Broad Institute, Cambridge, MA.
Yuhui ChenWellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, U.K.
Todd GreenProgram in Medical and Population Genetics, Broad Institute, Cambridge, MA.
Christopher HartlProgram in Medical and Population Genetics, Broad Institute, Cambridge, MA.
Hyun Min KangDepartment of Biostatistics and Center for Statistical Genetics, School of Public Health, University of Michigan, Ann Arbor, MI.
Ashish KumarWellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, U.K.
Claes LadenvallDiabetes and Endocrinology Unit, Department of Clinical Sciences Malmö, Lund University Diabetes Centre, Malmö, Sweden.
Clement MaDepartment of Biostatistics and Center for Statistical Genetics, School of Public Health, University of Michigan, Ann Arbor, MI.
Loukas MoutsianasWellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, U.K.
Richard D PearsonWellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, U.K.
John R B PerryWellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, U.K.
N William RaynerWellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, U.K.
Neil R RobertsonWellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, U.K.
Laura J ScottDepartment of Biostatistics and Center for Statistical Genetics, School of Public Health, University of Michigan, Ann Arbor, MI.
Martijn van de BuntWellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, U.K.
Johan G ErikssonDepartment of General Practice and Primary Health Care, University of Helsinki, Helsinki, Finland.
Antti JulaDepartment of Health, National Institute for Health and Welfare, Helsinki, Finland.
Seppo KoskinenDepartment of Health, National Institute for Health and Welfare, Helsinki, Finland.
Terho LehtimäkiDepartment of Clinical Chemistry, Fimlab Laboratories, University of Tampere School of Medicine, Tampere, Finland.
Aarno PalotieProgram in Medical and Population Genetics, Broad Institute, Cambridge, MA.
Olli T RaitakariDepartment of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku, Finland.
Suzanne B R JacobsProgram in Medical and Population Genetics, Broad Institute, Cambridge, MA.
Jennifer WesselDepartment of Epidemiology, Fairbanks School of Public Health, Indianapolis, IN.
Audrey Y ChuDivision of Preventive Medicine, Brigham and Women's Hospital, Boston, MA.
Robert A ScottMRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, U.K.
Mark O GoodarziDivision of Endocrinology, Diabetes & Metabolism, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA.
Christine BlancherHigh-Throughput Genomics, Oxford Genomics Centre, Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, U.K.
Gemma BuckHigh-Throughput Genomics, Oxford Genomics Centre, Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, U.K.
David BuckHigh-Throughput Genomics, Oxford Genomics Centre, Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, U.K.
Peter S ChinesNational Human Genome Research Institute, National Institutes of Health, Bethesda, MD.
Stacey GabrielProgram in Medical and Population Genetics, Broad Institute, Cambridge, MA.
Anette P GjesingThe Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Christopher J GrovesOxford Centre for Diabetes, Endocrinology & Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, U.K.
Mette HollenstedThe Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Jeroen R HuygheDepartment of Biostatistics and Center for Statistical Genetics, School of Public Health, University of Michigan, Ann Arbor, MI.
Anne U JacksonDepartment of Biostatistics and Center for Statistical Genetics, School of Public Health, University of Michigan, Ann Arbor, MI.
Goo JunDepartment of Biostatistics and Center for Statistical Genetics, School of Public Health, University of Michigan, Ann Arbor, MI.
Johanne Marie JustesenThe Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Massimo ManginoDepartment of Twin Research & Genetic Epidemiology, King's College London, London, U.K.
Jacquelyn MurphyProgram in Medical and Population Genetics, Broad Institute, Cambridge, MA.
Matt NevilleOxford Centre for Diabetes, Endocrinology & Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, U.K.
Robert OnofrioProgram in Medical and Population Genetics, Broad Institute, Cambridge, MA.
Kerrin S SmallDepartment of Twin Research & Genetic Epidemiology, King's College London, London, U.K.
Heather M StringhamDepartment of Biostatistics and Center for Statistical Genetics, School of Public Health, University of Michigan, Ann Arbor, MI.
Joseph TrakaloHigh-Throughput Genomics, Oxford Genomics Centre, Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, U.K.
Eric BanksProgram in Medical and Population Genetics, Broad Institute, Cambridge, MA.
Jason CareyProgram in Medical and Population Genetics, Broad Institute, Cambridge, MA.
Mauricio O CarneiroProgram in Medical and Population Genetics, Broad Institute, Cambridge, MA.
Mark DePristoProgram in Medical and Population Genetics, Broad Institute, Cambridge, MA.
Yossi FarjounProgram in Medical and Population Genetics, Broad Institute, Cambridge, MA.
Timothy FennellProgram in Medical and Population Genetics, Broad Institute, Cambridge, MA.
Jacqueline I GoldsteinProgram in Medical and Population Genetics, Broad Institute, Cambridge, MA.
George GrantProgram in Medical and Population Genetics, Broad Institute, Cambridge, MA.
Martin Hrabé de AngelisInstitute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.
Jared MaguireProgram in Medical and Population Genetics, Broad Institute, Cambridge, MA.
Benjamin M NealeProgram in Medical and Population Genetics, Broad Institute, Cambridge, MA.
Ryan PoplinProgram in Medical and Population Genetics, Broad Institute, Cambridge, MA.
Shaun PurcellProgram in Medical and Population Genetics, Broad Institute, Cambridge, MA.
Thomas SchwarzmayrInstitute of Human Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.
Khalid ShakirProgram in Medical and Population Genetics, Broad Institute, Cambridge, MA.
Joshua D SmithDepartment of Genome Sciences, University of Washington School of Medicine, Seattle, WA.
Tim M StromInstitute of Human Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.
Thomas WielandInstitute of Human Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.
Jaana LindstromDiabetes Prevention Unit, National Institute for Health and Welfare, Helsinki, Finland.
Ivan BrandslundDepartment of Regional Health Research, University of Southern Denmark, Odense, Denmark.
Cramer ChristensenDepartment of Internal Medicine and Endocrinology, Vejle Hospital, Vejle, Denmark.
Gabriela L SurdulescuDepartment of Twin Research & Genetic Epidemiology, King's College London, London, U.K.
Timo A LakkaDepartment of Physiology, Institute of Biomedicine, University of Eastern Finland, Kuopio, Finland.
Alex S F DoneyDivision of Cardiovascular & Diabetes Medicine, Medical Research Institute, Ninewells Hospital and Medical School, Dundee, U.K.
Peter NilssonDepartment of Clinical Sciences, Faculty of Medicine, Lund University, Malmö, Sweden.
Nicholas J WarehamMRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, U.K.
Claudia LangenbergMRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, U.K.
Tibor V VargaDepartment of Clinical Sciences, Lund University Diabetes Centre, and Genetic and Molecular Epidemiology Unit, Lund University, Malmö, Sweden.
Paul W FranksDepartment of Clinical Sciences, Lund University Diabetes Centre, and Genetic and Molecular Epidemiology Unit, Lund University, Malmö, Sweden.
Olov RolandssonDepartment of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden.
Anders H RosengrenDiabetes and Endocrinology Unit, Department of Clinical Sciences Malmö, Lund University Diabetes Centre, Malmö, Sweden.
Vidya S FarookDepartment of Genetics, Texas Biomedical Research Institute, San Antonio, TX.
Farook ThameemDepartment of Medicine, The University of Texas Health Science Center, San Antonio, TX.
Sobha PuppalaDepartment of Genetics, Texas Biomedical Research Institute, San Antonio, TX.
Satish KumarDepartment of Genetics, Texas Biomedical Research Institute, San Antonio, TX.
Donna M LehmanDepartment of Medicine, The University of Texas Health Science Center, San Antonio, TX.
Christopher P JenkinsonDepartment of Medicine, The University of Texas Health Science Center, San Antonio, TX.
Joanne E CurranDepartment of Genetics, Texas Biomedical Research Institute, San Antonio, TX.
Daniel Esten HaleDepartment of Pediatrics, The University of Texas Health Science Center, San Antonio, TX.
Sharon P FowlerDepartment of Medicine, The University of Texas Health Science Center, San Antonio, TX.
Rector AryaDepartment of Pediatrics, The University of Texas Health Science Center, San Antonio, TX.
Ralph A DeFronzoDepartment of Medicine, The University of Texas Health Science Center, San Antonio, TX.
Hanna E AbboudDepartment of Medicine, The University of Texas Health Science Center, San Antonio, TX.
Ann-Christine SyvänenMolecular Medicine and Science for Life Laboratory, Department of Medical Sciences, Uppsala University, Uppsala, Sweden.
Pamela J HicksCenter for Genomics and Personalized Medicine Research, Wake Forest School of Medicine, Winston-Salem, NC.
Nicholette D PalmerCenter for Genomics and Personalized Medicine Research, Wake Forest School of Medicine, Winston-Salem, NC.
Maggie C Y NgCenter for Genomics and Personalized Medicine Research, Wake Forest School of Medicine, Winston-Salem, NC.
Donald W BowdenCenter for Genomics and Personalized Medicine Research, Wake Forest School of Medicine, Winston-Salem, NC.
Barry I FreedmanSection on Nephrology, Department of Internal Medicine, Wake Forest School of Medicine, Winston-Salem, NC.
Tõnu EskoProgram in Medical and Population Genetics, Broad Institute, Cambridge, MA.
Reedik MägiEstonian Genome Center, University of Tartu, Tartu, Estonia.
Lili MilaniEstonian Genome Center, University of Tartu, Tartu, Estonia.
Evelin MihailovEstonian Genome Center, University of Tartu, Tartu, Estonia.
Andres MetspaluEstonian Genome Center, University of Tartu, Tartu, Estonia.
Narisu NarisuNational Human Genome Research Institute, National Institutes of Health, Bethesda, MD.
Leena KinnunenDepartment of Health, National Institute for Health and Welfare, Helsinki, Finland.
Lori L BonnycastleNational Human Genome Research Institute, National Institutes of Health, Bethesda, MD.
Amy SwiftNational Human Genome Research Institute, National Institutes of Health, Bethesda, MD.
Dorota PaskoGenetics of Complex Traits, University of Exeter Medical School, Exeter, U.K.
Andrew R WoodGenetics of Complex Traits, University of Exeter Medical School, Exeter, U.K.
João FadistaDiabetes and Endocrinology Unit, Department of Clinical Sciences Malmö, Lund University Diabetes Centre, Malmö, Sweden.
Toni I PollinProgram in Personalized and Genomic Medicine, Department of Medicine, University of Maryland, Baltimore, MD.
Nir BarzilaiDepartments of Medicine and Genetics, Albert Einstein College of Medicine, New York, NY.
Gil AtzmonDepartments of Medicine and Genetics, Albert Einstein College of Medicine, New York, NY.
Benjamin GlaserEndocrinology and Metabolism Service, Hadassah-Hebrew University Medical Center, Jerusalem, Israel.
Barbara ThorandGerman Center for Diabetes Research (DZD), Neuherberg, Germany.
Konstantin StrauchInstitute of Genetic Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.
Annette PetersGerman Center for Diabetes Research (DZD), Neuherberg, Germany.
Michael RodenInstitute of Clinical Diabetology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University, Düsseldorf, Germany.
Martina Müller-NurasyidInstitute of Genetic Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.
Liming LiangDepartment of Epidemiology, Harvard School of Public Health, Boston, MA.
Jennifer KriebelGerman Center for Diabetes Research (DZD), Neuherberg, Germany.
Thomas IlligResearch Unit Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.
Harald GrallertGerman Center for Diabetes Research (DZD), Neuherberg, Germany.
Christian GiegerInstitute of Genetic Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.
Christa MeisingerInstitute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.
Lars LannfeltGeriatrics, Department of Public Health and Caring Sciences, Uppsala University, Uppsala, Sweden.
Solomon K MusaniJackson Heart Study, University of Mississippi Medical Center, Jackson, MS.
Michael GriswoldCenter of Biostatistics and Bioinformatics, University of Mississippi Medical Center, Jackson, MS.
Herman A TaylorDepartment of Medicine, University of Mississippi Medical Center, Jackson, MS.
Gregory WilsonCollege of Public Services, Jackson State University, Jackson, MS.
Adolfo CorreaDepartment of Medicine, University of Mississippi Medical Center, Jackson, MS.
Heikki OksaPirkanmaa Hospital District, Tampere, Finland.
William R ScottDepartment of Epidemiology and Biostatistics, Imperial College London, London, U.K.
Uzma AfzalDepartment of Epidemiology and Biostatistics, Imperial College London, London, U.K.
Sian-Tsung TanCardiovascular Sciences, National Heart and Lung Institute, Imperial College London, London, U.K.
Marie LohDepartment of Epidemiology and Biostatistics, Imperial College London, London, U.K.
John C ChambersDepartment of Epidemiology and Biostatistics, Imperial College London, London, U.K.
Jobanpreet SehmiCardiovascular Sciences, National Heart and Lung Institute, Imperial College London, London, U.K.
Jaspal Singh KoonerCardiovascular Sciences, National Heart and Lung Institute, Imperial College London, London, U.K.
Benjamin LehneDepartment of Epidemiology and Biostatistics, Imperial College London, London, U.K.
Yoon Shin ChoDepartment of Biomedical Science, Hallym University, Chuncheon, Republic of Korea.
Jong-Young LeeMinistry of Health and Welfare, Seoul, Republic of Korea.
Bok-Ghee HanCenter for Genome Science, Korea National Research Institute of Health, Chungcheongbuk-do, Republic of Korea.
Annemari KäräjämäkiVaasa Health Care Center, Vaasa, Finland.
Qibin QiDepartment of Nutrition, Harvard School of Public Health, Boston, MA.
Lu QiDepartment of Nutrition, Harvard School of Public Health, Boston, MA.
Jinyan HuangDepartment of Epidemiology, Harvard School of Public Health, Boston, MA.
Frank B HuDepartment of Nutrition, Harvard School of Public Health, Boston, MA.
Olle MelanderHypertension and Cardiovascular Disease, Department of Clinical Sciences, Lund University, Malmö, Sweden.
Marju Orho-MelanderDiabetes and Cardiovascular Disease-Genetic Epidemiology, Department of Clinical Sciences, Lund University, Malmö, Sweden.
Jennifer E BelowHuman Genetics Center, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX.
David AguilarCardiovascular Division, Baylor College of Medicine, Houston, TX.
Tien Yin WongSingapore Eye Research Institute, Singapore National Eye Centre, Singapore.
Jianjun LiuSaw Swee Hock School of Public Health, National University of Singapore, Singapore.
Chiea-Chuen KhorSaw Swee Hock School of Public Health, National University of Singapore, Singapore.
Kee Seng ChiaSaw Swee Hock School of Public Health, National University of Singapore, Singapore.
Wei Yen LimSaw Swee Hock School of Public Health, National University of Singapore, Singapore.
Ching-Yu ChengSaw Swee Hock School of Public Health, National University of Singapore, Singapore.
Edmund ChanDepartment of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
E Shyong TaiSaw Swee Hock School of Public Health, National University of Singapore, Singapore.
Tin AungSingapore Eye Research Institute, Singapore National Eye Centre, Singapore.
Allan LinnebergResearch Centre for Prevention and Health, Glostrup University Hospital, Glostrup, Denmark.
Bo IsomaaFolkhälsan Research Center, Helsinki, Finland.
Thomas MeitingerInstitute of Human Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.
Tiinamaija TuomiFolkhälsan Research Center, Helsinki, Finland.
Liisa HakasteFolkhälsan Research Center, Helsinki, Finland.
Jasmina KravicDiabetes and Endocrinology Unit, Department of Clinical Sciences Malmö, Lund University Diabetes Centre, Malmö, Sweden.
Marit E JørgensenSteno Diabetes Center, Gentofte, Denmark.
Torsten LauritzenSection of General Practice, Department of Public Health, Aarhus University, Aarhus, Denmark.
Panos DeloukasDepartment of Human Genetics, Wellcome Trust Sanger Institute, Hinxton, U.K.
Kathleen E StirrupsWilliam Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, U.K.
Katharine R OwenOxford Centre for Diabetes, Endocrinology & Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, U.K.
Andrew J FarmerDepartment of Primary Care Health Sciences, University of Oxford, Oxford, U.K.
Timothy M FraylingGenetics of Complex Traits, University of Exeter Medical School, Exeter, U.K.
Stephen P O'RahillyMetabolic Research Laboratories, Institute of Metabolic Science, University of Cambridge, Cambridge, U.K.
Mark WalkerInstitute of Cellular Medicine, University of Newcastle, Newcastle, U.K.
Jonathan C LevyOxford Centre for Diabetes, Endocrinology & Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, U.K.
Dylan HodgkissDepartment of Twin Research & Genetic Epidemiology, King's College London, London, U.K.
Andrew T HattersleyUniversity of Exeter Medical School, Exeter, U.K.
Teemu KuulasmaaInternal Medicine, Institute of Clinical Medicine, Faculty of Health Sciences, University of Eastern Finland, Kuopio, Finland.
Alena StančákováInternal Medicine, Institute of Clinical Medicine, Faculty of Health Sciences, University of Eastern Finland, Kuopio, Finland.
Inês BarrosoDepartment of Human Genetics, Wellcome Trust Sanger Institute, Hinxton, U.K.
Dwaipayan BharadwajFunctional Genomics Unit, CSIR-Institute of Genomics & Integrative Biology, New Delhi, India.
Juliana ChanDepartment of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, China.
Giriraj R ChandakCSIR-Centre for Cellular & Molecular Biology, Hyderabad, India.
Mark J DalyAnalytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital, Boston, MA.
Peter J DonnellyWellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, U.K.
Shah B EbrahimCentre for Chronic Disease Control, New Delhi, India.
Paul ElliottDepartment of Epidemiology and Biostatistics, Imperial College London, London, U.K.
Tasha FingerlinDepartment of Epidemiology, Colorado School of Public Health, University of Colorado, Aurora, CO.
Philippe FroguelGenomics and Molecular Physiology, CNRS Institut de Biologie de Lille, Lille, France.
Cheng HuDepartment of Endocrinology and Metabolism, Shanghai Diabetes Institute, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.
Weiping JiaDepartment of Endocrinology and Metabolism, Shanghai Diabetes Institute, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.
Ronald C W MaDepartment of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, China.
Gilean McVeanWellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, U.K.
Taesung ParkInterdisciplinary Program in Bioinformatics, Seoul National University, Seoul, Republic of Korea.
Dorairaj PrabhakaranCentre for Chronic Disease Control, New Delhi, India.
Manjinder SandhuDepartment of Human Genetics, Wellcome Trust Sanger Institute, Hinxton, U.K.
James ScottCardiovascular Sciences, National Heart and Lung Institute, Imperial College London, London, U.K.
Rob SladekMcGill University and Génome Québec Innovation Centre, Montreal, Canada.
Nikhil TandonDepartment of Endocrinology and Metabolism, All India Institute of Medical Sciences, New Delhi, India.
Yik Ying TeoSaw Swee Hock School of Public Health, National University of Singapore, Singapore.
Eleftheria ZegginiDepartment of Human Genetics, Wellcome Trust Sanger Institute, Hinxton, U.K.
Richard M WatanabeDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA.
Heikki A KoistinenDepartment of Health, National Institute for Health and Welfare, Helsinki, Finland.
Y Antero KesaniemiInstitute of Clinical Medicine, Faculty of Medicine, University of Oulu, Oulu, Finland.
Matti UusitupaInstitute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland.
Timothy D SpectorDepartment of Twin Research & Genetic Epidemiology, King's College London, London, U.K.
Veikko SalomaaDepartment of Health, National Institute for Health and Welfare, Helsinki, Finland.
Rainer RauramaaFoundation for Research in Health Exercise and Nutrition, Kuopio Research Institute of Exercise Medicine, Kuopio, Finland.
Colin N A PalmerPat Macpherson Centre for Pharmacogenetics and Pharmacogenomics, Medical Research Institute, Ninewells Hospital and Medical School, Dundee, U.K.
Inga ProkopenkoWellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, U.K.
Andrew D MorrisDivision for Molecular Medicine, Clinical Research Centre, Ninewells Hospital and Medical School, Dundee, U.K.
Richard N BergmanDiabetes and Obesity Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA.
Francis S CollinsNational Human Genome Research Institute, National Institutes of Health, Bethesda, MD.
Lars LindDepartment of Medical Sciences, Uppsala University, Uppsala, Sweden.
Erik IngelssonMolecular Medicine and Science for Life Laboratory, Department of Medical Sciences, Uppsala University, Uppsala, Sweden.
Jaakko TuomilehtoDiabetes Prevention Unit, National Institute for Health and Welfare, Helsinki, Finland.
Fredrik KarpeOxford Centre for Diabetes, Endocrinology & Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, U.K.
Leif GroopDiabetes and Endocrinology Unit, Department of Clinical Sciences Malmö, Lund University Diabetes Centre, Malmö, Sweden.
Torben JørgensenResearch Centre for Prevention and Health, Glostrup University Hospital, Glostrup, Denmark.
Torben HansenThe Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Oluf PedersenThe Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Johanna KuusistoInternal Medicine, Institute of Clinical Medicine, Faculty of Health Sciences, University of Eastern Finland, Kuopio, Finland.
Gonçalo AbecasisDepartment of Biostatistics and Center for Statistical Genetics, School of Public Health, University of Michigan, Ann Arbor, MI.
Graeme I BellDepartments of Medicine and Human Genetics, The University of Chicago, Chicago, IL.
John BlangeroDepartment of Genetics, Texas Biomedical Research Institute, San Antonio, TX.
Nancy J CoxSection of Genetic Medicine, Department of Medicine, The University of Chicago, Chicago, IL.
Ravindranath DuggiralaDepartment of Genetics, Texas Biomedical Research Institute, San Antonio, TX.
Mark SeielstadDepartment of Laboratory Medicine, Institute for Human Genetics, University of California, San Francisco, San Francisco, CA.
James G WilsonDepartment of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, MS.
Josee DupuisDepartment of Biostatistics, Boston University School of Public Health, Boston, MA.
Samuli RipattiWellcome Trust Sanger Institute, Hinxton, U.K.
Craig L HanisHuman Genetics Center, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX.
Jose C FlorezProgram in Medical and Population Genetics, Broad Institute, Cambridge, MA.
Karen L MohlkeDepartment of Genetics, The University of North Carolina at Chapel Hill, Chapel Hill, NC.
James B MeigsProgram in Medical and Population Genetics, Broad Institute, Cambridge, MA.
Markku LaaksoInternal Medicine, Institute of Clinical Medicine, Faculty of Health Sciences, University of Eastern Finland, Kuopio, Finland.
Andrew P MorrisWellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, U.K.
Michael BoehnkeDepartment of Biostatistics and Center for Statistical Genetics, School of Public Health, University of Michigan, Ann Arbor, MI.
David AltshulerProgram in Medical and Population Genetics, Broad Institute, Cambridge, MA.
Mark I McCarthyWellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, U.K.
Anna L GloynWellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, U.K.
Cecilia M LindgrenProgram in Medical and Population Genetics, Broad Institute, Cambridge, MA.
Broad Institute · USCentre for Human Genetics · GBHelmholtz Zentrum München · DEUniversity of Michigan · USLund University · SENational University of Singapore · SGThe University of Texas Health Science Center at San Antonio · USUniversity of Copenhagen · DKTexas Biomedical Research Institute · USUniversity of Eastern Finland · FIFinnish Institute for Health and Welfare · FIKing's College London · GBNational Institutes of Health · USOxford Centre for Diabetes, Endocrinology and Metabolism · GBWake Forest University · USHarvard University · USImperial College London · GBUniversity of Exeter · GBUniversity of Mississippi Medical Center · USUniversity of Tartu · EE

Funding

Medical Scientist Training ProgramT32GM007753 · NIGMS · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI WALENSKY, LOREN DAVID · 1985 to 2021
$50.0M
Tracking and Evaluation CoreU54GM115428 · NIGMS · UNIVERSITY OF MISSISSIPPI MED CTR · PI JONES, ALAN E · 2016 to 2025
$38.2M
Genetic analysis of type II diabetes in Finnish populationZIAHG000024 · NHGRI · NATIONAL HUMAN GENOME RESEARCH INSTITUTE · PI ERDOS, MICHAEL · 2009 to 2025
$38.2M
Regional Pilot And Feasibility Study Grants ProgramP30DK020572 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI DAVID P OLSON · 2013 to 2026
$24.3M
Pilot and Feasibility ProgramP30DK020595 · NIDDK · UNIVERSITY OF CHICAGO · PI MANAMI HARA · 2013 to 2026
$20.9M
Low-Pass Sequencing and High-Density SNP Genotyping for Type 2 DiabetesRC2DK088389 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ALTSHULER, DAVID, BOEHNKE, MICHAEL L · 2009 to 2010
$17.9M
University of Michigan Training Program in Genomic ScienceT32HG000040 · NHGRI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Sebastian Zoellner · 1995 to 2026
$16.4M
Multiethnic Study of Type 2 Diabetes GenesU01DK085526 · NIDDK · BROAD INSTITUTE, INC. · PI ALTSHULER, DAVID, JABLONSKI, KATHLEEN ANN · 2009 to 2014
$15.7M
UCSF Nutrition Obesity Research CenterP30DK098722 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Allison W Xu · 2015 to 2026
$14.6M
Identifying Genes for Type 2 Diabetes: FUSIONU01DK062370 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BOEHNKE, MICHAEL L, SCOTT, LAURA J. · 2009 to 2021
$11.6M
Targeted Genetic Analysis of T2D and Quantitative TraitsR01DK072193 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI KAREN L. MOHLKE · 2005 to 2026
$11.3M
Einstein's Nathan Shock Center of Excellence in Basic Biology of AgingP30AG038072 · NIA · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI BARZILAI, NIR J · 2010 to 2024
$10.8M
CCR NIH HHS HHSN261200800001CDepartment of Health NF-SI-0611-10219Department of Health RP-PG-0407-10371Intramural NIH HHS Z01 HG000024Medical Research Council G0601261Medical Research Council G0601966Medical Research Council G0700931Medical Research Council MC_PC_13040Medical Research Council MC_UU_12015/1Medical Research Council MC_UU_12015/2Medical Research Council MR/K002414/1Medical Research Council MR/K007017/1Medical Research Council MR/L01341X/1Medical Research Council MR/M501633/1Medical Research Council MR/M501633/2NCI NIH HHS HHSN261200800001ENCI NIH HHS K12 CA139160NHGRI NIH HHS T32 HG000040NHLBI NIH HHS HHSN268201000029CNHLBI NIH HHS HHSN268201300046CNHLBI NIH HHS HHSN268201300047CNHLBI NIH HHS HHSN268201300048CNHLBI NIH HHS HHSN268201300049CNHLBI NIH HHS HHSN268201300050CNHLBI NIH HHS R01 HL102830NHLBI NIH HHS R01 HL105756NHLBI NIH HHS T32 HL007055NIA NIH HHS P01 AG027734NIA NIH HHS P30 AG038072NIA NIH HHS R01 AG042188NIA NIH HHS R01 AG046949NIDA NIH HHS R01 DA006227NIDA NIH HHS R01 DA033684NIDDK NIH HHS K24 DK080140NIDDK NIH HHS K24 DK110550NIDDK NIH HHS P30 DK020572NIDDK NIH HHS P30 DK020595NIDDK NIH HHS P30 DK092949NIDDK NIH HHS P30 DK098722NIDDK NIH HHS R01 DK062370NIDDK NIH HHS R01 DK066358NIDDK NIH HHS R01 DK072193NIDDK NIH HHS R01 DK073541NIDDK NIH HHS R01 DK078616NIDDK NIH HHS R01 DK093757NIDDK NIH HHS R01 DK098032NIDDK NIH HHS R01 DK106236NIDDK NIH HHS RC2 DK088389NIDDK NIH HHS U01 DK062370NIDDK NIH HHS U01 DK078616NIDDK NIH HHS U01 DK085501NIDDK NIH HHS U01 DK085524NIDDK NIH HHS U01 DK085526NIDDK NIH HHS U01 DK085545NIDDK NIH HHS U01 DK085584NIDDK NIH HHS U01 DK105561NIGMS NIH HHS T32 GM007753NIGMS NIH HHS U54 GM115428NIMH NIH HHS R01 MH090936NIMH NIH HHS R01 MH090937NIMH NIH HHS R01 MH090941NIMH NIH HHS R01 MH090948NIMH NIH HHS R01 MH090951NIMH NIH HHS R01 MH101782NIMH NIH HHS R01 MH101810NIMH NIH HHS R01 MH101814NIMH NIH HHS R01 MH101819NIMH NIH HHS R01 MH101820NIMH NIH HHS R01 MH101822NIMH NIH HHS R01 MH101825NIMH NIH HHS R01 MH107666Wellcome Trust 095101Wellcome Trust 098395Wellcome Trust 200837
6 · The paper itself

Abstract

To identify novel coding association signals and facilitate characterization of mechanisms influencing glycemic traits and type 2 diabetes risk, we analyzed 109,215 variants derived from exome array genotyping together with an additional 390,225 variants from exome sequence in up to 39,339 normoglycemic individuals from five ancestry groups. We identified a novel association between the coding variant (p.Pro50Thr) in

Indexed as

AllelesAsian PeopleBlack or African AmericanCase-Control StudiesDiabetes Mellitus, Type 2FastingFinlandGene FrequencyGenetic Predisposition to DiseaseGenotypeHispanic or LatinoHumansInsulinInsulin ResistanceOdds RatioProto-Oncogene Proteins c-aktAKT2 protein, humanInsulinProto-Oncogene Proteins c-akt

Identifiers

PMID28341696
PMCPMC5482074
OpenAlexW2601522016

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.