Evidence map›Paper›PMID 28341646›Full record

ArticleNeurology2017

Cardiorespiratory fitness alters the influence of a polygenic risk score on biomarkers of AD.

Stephanie A Schultz, Elizabeth A Boots, Burcu F Darst, Henrik Zetterberg, Kaj Blennow, Dorothy F Edwards, Rebecca L Koscik, Cynthia M Carlsson, Catherine L Gallagher, Barbara B Bendlin and 8 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 3 pooled it
5.7field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 3 syntheses or guidelines pooled it, 44 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
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  4. Trial
  5. Physical activity across the life course and neural biomarkers.Journal of Alzheimer's disease : JAD · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 3 institutions in 2 countries.

Stephanie A SchultzFrom the Geriatric Research Education and Clinical Center (S.A.S., E.A.B., C.M.C., C.L.G., B.B.B., S.A., S.C.J., O.C.O.) and Research Service (D.B.C.), William S. Middleton Memorial VA Hospital, Madison, WI; Wisconsin Alzheimer's Disease Research Center (S.A.S., E.A.B., D.F.E., R.L.K., C.M.C., B.B.B., S.A., M.A.S., B.P.H., S.C.J., C.D.E., O.C.O.), Madison; Departments of Population Health Sciences (B.F.D., C.D.E.), Kinesiology (D.F.E., D.B.C.), Neurology (C.L.G.), and Anesthesiology (K.J.H.), University of Wisconsin School of Medicine and Public Health, Madison; Clinical Neurochemistry Laboratory (H.Z., K.B.), Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Sweden; Department of Molecular Neuroscience (H.Z.), UCL Institute of Neurology, Queen Square, London, UK; and Wisconsin Alzheimer's Institute (D.F.E., C.M.C., C.L.G., B.B.B., S.A., M.A.S., K.J.H., B.P.H., S.C.J., C.D.E., O.C.O.), Madison.
Elizabeth A BootsFrom the Geriatric Research Education and Clinical Center (S.A.S., E.A.B., C.M.C., C.L.G., B.B.B., S.A., S.C.J., O.C.O.) and Research Service (D.B.C.), William S. Middleton Memorial VA Hospital, Madison, WI; Wisconsin Alzheimer's Disease Research Center (S.A.S., E.A.B., D.F.E., R.L.K., C.M.C., B.B.B., S.A., M.A.S., B.P.H., S.C.J., C.D.E., O.C.O.), Madison; Departments of Population Health Sciences (B.F.D., C.D.E.), Kinesiology (D.F.E., D.B.C.), Neurology (C.L.G.), and Anesthesiology (K.J.H.), University of Wisconsin School of Medicine and Public Health, Madison; Clinical Neurochemistry Laboratory (H.Z., K.B.), Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Sweden; Department of Molecular Neuroscience (H.Z.), UCL Institute of Neurology, Queen Square, London, UK; and Wisconsin Alzheimer's Institute (D.F.E., C.M.C., C.L.G., B.B.B., S.A., M.A.S., K.J.H., B.P.H., S.C.J., C.D.E., O.C.O.), Madison.
Burcu F DarstFrom the Geriatric Research Education and Clinical Center (S.A.S., E.A.B., C.M.C., C.L.G., B.B.B., S.A., S.C.J., O.C.O.) and Research Service (D.B.C.), William S. Middleton Memorial VA Hospital, Madison, WI; Wisconsin Alzheimer's Disease Research Center (S.A.S., E.A.B., D.F.E., R.L.K., C.M.C., B.B.B., S.A., M.A.S., B.P.H., S.C.J., C.D.E., O.C.O.), Madison; Departments of Population Health Sciences (B.F.D., C.D.E.), Kinesiology (D.F.E., D.B.C.), Neurology (C.L.G.), and Anesthesiology (K.J.H.), University of Wisconsin School of Medicine and Public Health, Madison; Clinical Neurochemistry Laboratory (H.Z., K.B.), Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Sweden; Department of Molecular Neuroscience (H.Z.), UCL Institute of Neurology, Queen Square, London, UK; and Wisconsin Alzheimer's Institute (D.F.E., C.M.C., C.L.G., B.B.B., S.A., M.A.S., K.J.H., B.P.H., S.C.J., C.D.E., O.C.O.), Madison.
Henrik ZetterbergFrom the Geriatric Research Education and Clinical Center (S.A.S., E.A.B., C.M.C., C.L.G., B.B.B., S.A., S.C.J., O.C.O.) and Research Service (D.B.C.), William S. Middleton Memorial VA Hospital, Madison, WI; Wisconsin Alzheimer's Disease Research Center (S.A.S., E.A.B., D.F.E., R.L.K., C.M.C., B.B.B., S.A., M.A.S., B.P.H., S.C.J., C.D.E., O.C.O.), Madison; Departments of Population Health Sciences (B.F.D., C.D.E.), Kinesiology (D.F.E., D.B.C.), Neurology (C.L.G.), and Anesthesiology (K.J.H.), University of Wisconsin School of Medicine and Public Health, Madison; Clinical Neurochemistry Laboratory (H.Z., K.B.), Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Sweden; Department of Molecular Neuroscience (H.Z.), UCL Institute of Neurology, Queen Square, London, UK; and Wisconsin Alzheimer's Institute (D.F.E., C.M.C., C.L.G., B.B.B., S.A., M.A.S., K.J.H., B.P.H., S.C.J., C.D.E., O.C.O.), Madison.
Kaj BlennowFrom the Geriatric Research Education and Clinical Center (S.A.S., E.A.B., C.M.C., C.L.G., B.B.B., S.A., S.C.J., O.C.O.) and Research Service (D.B.C.), William S. Middleton Memorial VA Hospital, Madison, WI; Wisconsin Alzheimer's Disease Research Center (S.A.S., E.A.B., D.F.E., R.L.K., C.M.C., B.B.B., S.A., M.A.S., B.P.H., S.C.J., C.D.E., O.C.O.), Madison; Departments of Population Health Sciences (B.F.D., C.D.E.), Kinesiology (D.F.E., D.B.C.), Neurology (C.L.G.), and Anesthesiology (K.J.H.), University of Wisconsin School of Medicine and Public Health, Madison; Clinical Neurochemistry Laboratory (H.Z., K.B.), Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Sweden; Department of Molecular Neuroscience (H.Z.), UCL Institute of Neurology, Queen Square, London, UK; and Wisconsin Alzheimer's Institute (D.F.E., C.M.C., C.L.G., B.B.B., S.A., M.A.S., K.J.H., B.P.H., S.C.J., C.D.E., O.C.O.), Madison.
Dorothy F EdwardsFrom the Geriatric Research Education and Clinical Center (S.A.S., E.A.B., C.M.C., C.L.G., B.B.B., S.A., S.C.J., O.C.O.) and Research Service (D.B.C.), William S. Middleton Memorial VA Hospital, Madison, WI; Wisconsin Alzheimer's Disease Research Center (S.A.S., E.A.B., D.F.E., R.L.K., C.M.C., B.B.B., S.A., M.A.S., B.P.H., S.C.J., C.D.E., O.C.O.), Madison; Departments of Population Health Sciences (B.F.D., C.D.E.), Kinesiology (D.F.E., D.B.C.), Neurology (C.L.G.), and Anesthesiology (K.J.H.), University of Wisconsin School of Medicine and Public Health, Madison; Clinical Neurochemistry Laboratory (H.Z., K.B.), Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Sweden; Department of Molecular Neuroscience (H.Z.), UCL Institute of Neurology, Queen Square, London, UK; and Wisconsin Alzheimer's Institute (D.F.E., C.M.C., C.L.G., B.B.B., S.A., M.A.S., K.J.H., B.P.H., S.C.J., C.D.E., O.C.O.), Madison.
Rebecca L KoscikFrom the Geriatric Research Education and Clinical Center (S.A.S., E.A.B., C.M.C., C.L.G., B.B.B., S.A., S.C.J., O.C.O.) and Research Service (D.B.C.), William S. Middleton Memorial VA Hospital, Madison, WI; Wisconsin Alzheimer's Disease Research Center (S.A.S., E.A.B., D.F.E., R.L.K., C.M.C., B.B.B., S.A., M.A.S., B.P.H., S.C.J., C.D.E., O.C.O.), Madison; Departments of Population Health Sciences (B.F.D., C.D.E.), Kinesiology (D.F.E., D.B.C.), Neurology (C.L.G.), and Anesthesiology (K.J.H.), University of Wisconsin School of Medicine and Public Health, Madison; Clinical Neurochemistry Laboratory (H.Z., K.B.), Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Sweden; Department of Molecular Neuroscience (H.Z.), UCL Institute of Neurology, Queen Square, London, UK; and Wisconsin Alzheimer's Institute (D.F.E., C.M.C., C.L.G., B.B.B., S.A., M.A.S., K.J.H., B.P.H., S.C.J., C.D.E., O.C.O.), Madison.
Cynthia M CarlssonFrom the Geriatric Research Education and Clinical Center (S.A.S., E.A.B., C.M.C., C.L.G., B.B.B., S.A., S.C.J., O.C.O.) and Research Service (D.B.C.), William S. Middleton Memorial VA Hospital, Madison, WI; Wisconsin Alzheimer's Disease Research Center (S.A.S., E.A.B., D.F.E., R.L.K., C.M.C., B.B.B., S.A., M.A.S., B.P.H., S.C.J., C.D.E., O.C.O.), Madison; Departments of Population Health Sciences (B.F.D., C.D.E.), Kinesiology (D.F.E., D.B.C.), Neurology (C.L.G.), and Anesthesiology (K.J.H.), University of Wisconsin School of Medicine and Public Health, Madison; Clinical Neurochemistry Laboratory (H.Z., K.B.), Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Sweden; Department of Molecular Neuroscience (H.Z.), UCL Institute of Neurology, Queen Square, London, UK; and Wisconsin Alzheimer's Institute (D.F.E., C.M.C., C.L.G., B.B.B., S.A., M.A.S., K.J.H., B.P.H., S.C.J., C.D.E., O.C.O.), Madison.
Catherine L GallagherFrom the Geriatric Research Education and Clinical Center (S.A.S., E.A.B., C.M.C., C.L.G., B.B.B., S.A., S.C.J., O.C.O.) and Research Service (D.B.C.), William S. Middleton Memorial VA Hospital, Madison, WI; Wisconsin Alzheimer's Disease Research Center (S.A.S., E.A.B., D.F.E., R.L.K., C.M.C., B.B.B., S.A., M.A.S., B.P.H., S.C.J., C.D.E., O.C.O.), Madison; Departments of Population Health Sciences (B.F.D., C.D.E.), Kinesiology (D.F.E., D.B.C.), Neurology (C.L.G.), and Anesthesiology (K.J.H.), University of Wisconsin School of Medicine and Public Health, Madison; Clinical Neurochemistry Laboratory (H.Z., K.B.), Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Sweden; Department of Molecular Neuroscience (H.Z.), UCL Institute of Neurology, Queen Square, London, UK; and Wisconsin Alzheimer's Institute (D.F.E., C.M.C., C.L.G., B.B.B., S.A., M.A.S., K.J.H., B.P.H., S.C.J., C.D.E., O.C.O.), Madison.
Barbara B BendlinFrom the Geriatric Research Education and Clinical Center (S.A.S., E.A.B., C.M.C., C.L.G., B.B.B., S.A., S.C.J., O.C.O.) and Research Service (D.B.C.), William S. Middleton Memorial VA Hospital, Madison, WI; Wisconsin Alzheimer's Disease Research Center (S.A.S., E.A.B., D.F.E., R.L.K., C.M.C., B.B.B., S.A., M.A.S., B.P.H., S.C.J., C.D.E., O.C.O.), Madison; Departments of Population Health Sciences (B.F.D., C.D.E.), Kinesiology (D.F.E., D.B.C.), Neurology (C.L.G.), and Anesthesiology (K.J.H.), University of Wisconsin School of Medicine and Public Health, Madison; Clinical Neurochemistry Laboratory (H.Z., K.B.), Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Sweden; Department of Molecular Neuroscience (H.Z.), UCL Institute of Neurology, Queen Square, London, UK; and Wisconsin Alzheimer's Institute (D.F.E., C.M.C., C.L.G., B.B.B., S.A., M.A.S., K.J.H., B.P.H., S.C.J., C.D.E., O.C.O.), Madison.
Sanjay AsthanaFrom the Geriatric Research Education and Clinical Center (S.A.S., E.A.B., C.M.C., C.L.G., B.B.B., S.A., S.C.J., O.C.O.) and Research Service (D.B.C.), William S. Middleton Memorial VA Hospital, Madison, WI; Wisconsin Alzheimer's Disease Research Center (S.A.S., E.A.B., D.F.E., R.L.K., C.M.C., B.B.B., S.A., M.A.S., B.P.H., S.C.J., C.D.E., O.C.O.), Madison; Departments of Population Health Sciences (B.F.D., C.D.E.), Kinesiology (D.F.E., D.B.C.), Neurology (C.L.G.), and Anesthesiology (K.J.H.), University of Wisconsin School of Medicine and Public Health, Madison; Clinical Neurochemistry Laboratory (H.Z., K.B.), Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Sweden; Department of Molecular Neuroscience (H.Z.), UCL Institute of Neurology, Queen Square, London, UK; and Wisconsin Alzheimer's Institute (D.F.E., C.M.C., C.L.G., B.B.B., S.A., M.A.S., K.J.H., B.P.H., S.C.J., C.D.E., O.C.O.), Madison.
Mark A SagerFrom the Geriatric Research Education and Clinical Center (S.A.S., E.A.B., C.M.C., C.L.G., B.B.B., S.A., S.C.J., O.C.O.) and Research Service (D.B.C.), William S. Middleton Memorial VA Hospital, Madison, WI; Wisconsin Alzheimer's Disease Research Center (S.A.S., E.A.B., D.F.E., R.L.K., C.M.C., B.B.B., S.A., M.A.S., B.P.H., S.C.J., C.D.E., O.C.O.), Madison; Departments of Population Health Sciences (B.F.D., C.D.E.), Kinesiology (D.F.E., D.B.C.), Neurology (C.L.G.), and Anesthesiology (K.J.H.), University of Wisconsin School of Medicine and Public Health, Madison; Clinical Neurochemistry Laboratory (H.Z., K.B.), Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Sweden; Department of Molecular Neuroscience (H.Z.), UCL Institute of Neurology, Queen Square, London, UK; and Wisconsin Alzheimer's Institute (D.F.E., C.M.C., C.L.G., B.B.B., S.A., M.A.S., K.J.H., B.P.H., S.C.J., C.D.E., O.C.O.), Madison.
Kirk J HoganFrom the Geriatric Research Education and Clinical Center (S.A.S., E.A.B., C.M.C., C.L.G., B.B.B., S.A., S.C.J., O.C.O.) and Research Service (D.B.C.), William S. Middleton Memorial VA Hospital, Madison, WI; Wisconsin Alzheimer's Disease Research Center (S.A.S., E.A.B., D.F.E., R.L.K., C.M.C., B.B.B., S.A., M.A.S., B.P.H., S.C.J., C.D.E., O.C.O.), Madison; Departments of Population Health Sciences (B.F.D., C.D.E.), Kinesiology (D.F.E., D.B.C.), Neurology (C.L.G.), and Anesthesiology (K.J.H.), University of Wisconsin School of Medicine and Public Health, Madison; Clinical Neurochemistry Laboratory (H.Z., K.B.), Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Sweden; Department of Molecular Neuroscience (H.Z.), UCL Institute of Neurology, Queen Square, London, UK; and Wisconsin Alzheimer's Institute (D.F.E., C.M.C., C.L.G., B.B.B., S.A., M.A.S., K.J.H., B.P.H., S.C.J., C.D.E., O.C.O.), Madison.
Bruce P HermannFrom the Geriatric Research Education and Clinical Center (S.A.S., E.A.B., C.M.C., C.L.G., B.B.B., S.A., S.C.J., O.C.O.) and Research Service (D.B.C.), William S. Middleton Memorial VA Hospital, Madison, WI; Wisconsin Alzheimer's Disease Research Center (S.A.S., E.A.B., D.F.E., R.L.K., C.M.C., B.B.B., S.A., M.A.S., B.P.H., S.C.J., C.D.E., O.C.O.), Madison; Departments of Population Health Sciences (B.F.D., C.D.E.), Kinesiology (D.F.E., D.B.C.), Neurology (C.L.G.), and Anesthesiology (K.J.H.), University of Wisconsin School of Medicine and Public Health, Madison; Clinical Neurochemistry Laboratory (H.Z., K.B.), Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Sweden; Department of Molecular Neuroscience (H.Z.), UCL Institute of Neurology, Queen Square, London, UK; and Wisconsin Alzheimer's Institute (D.F.E., C.M.C., C.L.G., B.B.B., S.A., M.A.S., K.J.H., B.P.H., S.C.J., C.D.E., O.C.O.), Madison.
Dane B CookFrom the Geriatric Research Education and Clinical Center (S.A.S., E.A.B., C.M.C., C.L.G., B.B.B., S.A., S.C.J., O.C.O.) and Research Service (D.B.C.), William S. Middleton Memorial VA Hospital, Madison, WI; Wisconsin Alzheimer's Disease Research Center (S.A.S., E.A.B., D.F.E., R.L.K., C.M.C., B.B.B., S.A., M.A.S., B.P.H., S.C.J., C.D.E., O.C.O.), Madison; Departments of Population Health Sciences (B.F.D., C.D.E.), Kinesiology (D.F.E., D.B.C.), Neurology (C.L.G.), and Anesthesiology (K.J.H.), University of Wisconsin School of Medicine and Public Health, Madison; Clinical Neurochemistry Laboratory (H.Z., K.B.), Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Sweden; Department of Molecular Neuroscience (H.Z.), UCL Institute of Neurology, Queen Square, London, UK; and Wisconsin Alzheimer's Institute (D.F.E., C.M.C., C.L.G., B.B.B., S.A., M.A.S., K.J.H., B.P.H., S.C.J., C.D.E., O.C.O.), Madison.
Sterling C JohnsonFrom the Geriatric Research Education and Clinical Center (S.A.S., E.A.B., C.M.C., C.L.G., B.B.B., S.A., S.C.J., O.C.O.) and Research Service (D.B.C.), William S. Middleton Memorial VA Hospital, Madison, WI; Wisconsin Alzheimer's Disease Research Center (S.A.S., E.A.B., D.F.E., R.L.K., C.M.C., B.B.B., S.A., M.A.S., B.P.H., S.C.J., C.D.E., O.C.O.), Madison; Departments of Population Health Sciences (B.F.D., C.D.E.), Kinesiology (D.F.E., D.B.C.), Neurology (C.L.G.), and Anesthesiology (K.J.H.), University of Wisconsin School of Medicine and Public Health, Madison; Clinical Neurochemistry Laboratory (H.Z., K.B.), Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Sweden; Department of Molecular Neuroscience (H.Z.), UCL Institute of Neurology, Queen Square, London, UK; and Wisconsin Alzheimer's Institute (D.F.E., C.M.C., C.L.G., B.B.B., S.A., M.A.S., K.J.H., B.P.H., S.C.J., C.D.E., O.C.O.), Madison.
Corinne D EngelmanFrom the Geriatric Research Education and Clinical Center (S.A.S., E.A.B., C.M.C., C.L.G., B.B.B., S.A., S.C.J., O.C.O.) and Research Service (D.B.C.), William S. Middleton Memorial VA Hospital, Madison, WI; Wisconsin Alzheimer's Disease Research Center (S.A.S., E.A.B., D.F.E., R.L.K., C.M.C., B.B.B., S.A., M.A.S., B.P.H., S.C.J., C.D.E., O.C.O.), Madison; Departments of Population Health Sciences (B.F.D., C.D.E.), Kinesiology (D.F.E., D.B.C.), Neurology (C.L.G.), and Anesthesiology (K.J.H.), University of Wisconsin School of Medicine and Public Health, Madison; Clinical Neurochemistry Laboratory (H.Z., K.B.), Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Sweden; Department of Molecular Neuroscience (H.Z.), UCL Institute of Neurology, Queen Square, London, UK; and Wisconsin Alzheimer's Institute (D.F.E., C.M.C., C.L.G., B.B.B., S.A., M.A.S., K.J.H., B.P.H., S.C.J., C.D.E., O.C.O.), Madison.
Ozioma C OkonkwoFrom the Geriatric Research Education and Clinical Center (S.A.S., E.A.B., C.M.C., C.L.G., B.B.B., S.A., S.C.J., O.C.O.) and Research Service (D.B.C.), William S. Middleton Memorial VA Hospital, Madison, WI; Wisconsin Alzheimer's Disease Research Center (S.A.S., E.A.B., D.F.E., R.L.K., C.M.C., B.B.B., S.A., M.A.S., B.P.H., S.C.J., C.D.E., O.C.O.), Madison; Departments of Population Health Sciences (B.F.D., C.D.E.), Kinesiology (D.F.E., D.B.C.), Neurology (C.L.G.), and Anesthesiology (K.J.H.), University of Wisconsin School of Medicine and Public Health, Madison; Clinical Neurochemistry Laboratory (H.Z., K.B.), Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Sweden; Department of Molecular Neuroscience (H.Z.), UCL Institute of Neurology, Queen Square, London, UK; and Wisconsin Alzheimer's Institute (D.F.E., C.M.C., C.L.G., B.B.B., S.A., M.A.S., K.J.H., B.P.H., S.C.J., C.D.E., O.C.O.), Madison. ozioma@medicine.wisc.edu.
University of Gothenburg · SEUniversity College London · GBNational Hospital for Neurology and Neurosurgery · GB

Funding

Wisconsin Registry for Alzheimer's Prevention: Sex Differences in DNA MethylationR01AG027161 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI Nathaniel Ark Chin, Sterling C Johnson · 2007 to 2026
$35.6M
The Longitudinal Course of Neural Function and Amyloid in People At Risk for ADR01AG021155 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI Sterling C Johnson · 2004 to 2026
$27.0M
Research Training for Computation and Informatics in Biology and MedicineT15LM007359 · NLM · UNIVERSITY OF WISCONSIN-MADISON · PI Mark W. Craven, Colin Noel Dewey · 2002 to 2026
$22.6M
Wisconsin Alzheimer's Disease Research CenterP50AG033514 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI ASTHANA, SANJAY · 2009 to 2018
$16.2M
White matter degeneration: biomarkers in preclinical Alzheimer's DiseaseR01AG037639 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI BENDLIN, BARBARA BRIGITTA · 2012 to 2023
$5.3M
Genomic and Metabolomic Data Integration in a Longitudinal Cohort at Risk for Alzheimer's DiseaseR01AG054047 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI ENGELMAN, CORINNE D. · 2016 to 2020
$3.6M
Statin Effects on Beta-Amyloid and Cerebral Perfusion in Adults at Risk for ADR01AG031790 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI CARLSSON, CYNTHIA M · 2009 to 2013
$1.6M
Early detection of asymptomatic middle-age adults at risk for ADK23AG045957 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI OKONKWO, OZIOMA C · 2013 to 2017
$884k
White matter degeneration: biomarkers in preclinical Alzheimer's DiseaseR56AG037639 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI BENDLIN, BARBARA BRIGITTA · 2017 to 2017
$759k
NIA NIH HHS K23 AG045957NIA NIH HHS P50 AG033514NIA NIH HHS R01 AG021155NIA NIH HHS R01 AG027161NIA NIH HHS R01 AG031790NIA NIH HHS R01 AG037639NIA NIH HHS R01 AG054047NIA NIH HHS R56 AG037639NLM NIH HHS T15 LM007359
6 · The paper itself

Abstract

objectiveTo examine whether a polygenic risk score (PRS) derived from

methodsNinety-five individuals from the Wisconsin Registry for Alzheimer's Prevention were included in these cross-sectional analyses. They were genotyped for

resultsA higher PRS was associated with lower Aβ

conclusionsIn a late-middle-aged cohort, CRF attenuates the adverse influence of genetic vulnerability on CSF biomarkers. These findings support the notion that increased cardiorespiratory fitness may be beneficial to those at increased genetic risk for AD.

Indexed as

AgedAlzheimer DiseaseAmyloid beta-PeptidesApolipoprotein E4ATP-Binding Cassette TransportersBiomarkersCardiorespiratory FitnessClusterinCohort StudiesCross-Sectional StudiesFemaleHumansMaleMiddle AgedMultifactorial InheritancePeptide FragmentsABCA7 protein, humanAmyloid beta-Peptidesamyloid beta-protein (1-40)amyloid beta-protein (1-42)Apolipoprotein E4ATP-Binding Cassette TransportersBiomarkersCLU protein, humanClusterinMAPT protein, humanPeptide Fragmentstau Proteins

Identifiers

PMID28341646
PMCPMC5405766
OpenAlexW2602772966

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.