Evidence map›Paper›PMID 28341641›Full record

ArticleThe Journal of experimental medicine2017

Proliferation of latently infected CD4

Nina N Hosmane, Kyungyoon J Kwon, Katherine M Bruner, Adam A Capoferri, Subul Beg, Daniel I S Rosenbloom, Brandon F Keele, Ya-Chi Ho, Janet D Siliciano, Robert F Siliciano

Registry-linked trialOpen access · hybridAbstract read
In one paragraph

Article in The Journal of experimental medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04263207 (Observational Study for the Evaluation of the Role of HIV-1 Tat Protein and Anti-Tat Immune Response in Peripheral Blood HIV Reservoir Dynamics), which is not on this map. Cited by 302 papers.

0numbers the graph read from it
0cells of the map it votes in
302citing papers in PubMed
28.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04263207 suspendednot on this mapstarted 2020, after this paper: background citation

Observational Study for the Evaluation of the Role of HIV-1 Tat Protein and Anti-Tat Immune Response in Peripheral Blood HIV Reservoir Dynamics

TypeobservationalSponsorBarbara Ensoli, MD, PhDRan2020 to 2025Enrolled100ConditionsHIV/AIDSArmsNo intervention
3 · Its place in the literature

Who cites it

302 citing papers in PubMed, 385 citations in OpenAlex.

  1. Trial
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  3. Article
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  6. The immunophenotype and proviral landscape of HIV-infected CD4 T cells during antiretroviral therapy.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
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  10. Review
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  18. Review
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242 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Nina N HosmaneDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205.
Kyungyoon J KwonDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205.
Katherine M BrunerDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205.
Adam A CapoferriDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205.
Subul BegDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205.ORCID 0000-0003-1862-6012
Daniel I S RosenbloomDepartment of Biomedical Informatics, Columbia University Medical Center, New York, NY 10032.
Brandon F KeeleAIDS and Cancer Virus Program, Leidos Biomedical Research Inc., Frederick National Laboratory for Cancer Research, Frederick, MD 21702.
Ya-Chi HoDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205.
Janet D SilicianoDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205.ORCID 0000-0001-6712-3775
Robert F SilicianoDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205 rsiliciano@jhmi.edu.ORCID 0000-0002-1764-1993
Johns Hopkins University · USColumbia University Irving Medical Center · USHoward Hughes Medical Institute · USLeidos (United States) · US

Funding

Vaccine Response and Immunotherapeutics SWGP30AI094189 · NIAID · JOHNS HOPKINS UNIVERSITY · PI Richard E. Chaisson · 2012 to 2026
$67.0M
Delaney AIDS Research Enterprise to Cure HIVUM1AI126611 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI DEEKS, STEVEN GRANT, PICKER, LOUIS J. · 2016 to 2020
$27.9M
First-in-human study of two anti-SARS CoV-2 antibodies in health volunteersUM1AI126620 · NIAID · WISTAR INSTITUTE · PI MONTANER, LUIS J, RILEY, JAMES L. · 2016 to 2021
$24.5M
Combined Immunologic Approaches to Cure HIV-1UM1AI126603 · NIAID · BETH ISRAEL DEACONESS MEDICAL CENTER · PI BAROUCH, DAN H., MELLORS, JOHN W · 2016 to 2020
$23.6M
Training Program in Cellular and Molecular MedicineT32GM008752 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI RAO, RAJINI · 2000 to 2019
$11.7M
CCR NIH HHS HHSN261200800001CHoward Hughes Medical InstituteNCI NIH HHS HHSN261200800001ENIAID NIH HHS P30 AI094189NIAID NIH HHS UM1 AI126603NIAID NIH HHS UM1 AI126611NIAID NIH HHS UM1 AI126620NIGMS NIH HHS T32 GM008752
6 · The paper itself

Abstract

A latent reservoir for HIV-1 in resting CD4

Indexed as

Lymphocyte ActivationVirus ReplicationCD4-Positive T-LymphocytesGenome, ViralHIV-1Humans

Identifiers

PMID28341641
PMCPMC5379987
OpenAlexW2598871150

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.