Evidence map›Paper›PMID 28341633›Full record

ArticleAmerican journal of physiology. Heart and circulatory physiology2017

Increased hypoxia-inducible factor-1α in striated muscle of tumor-bearing mice.

Raymond D Devine, Sabahattin Bicer, Peter J Reiser, Loren E Wold

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of physiology. Heart and circulatory physiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 2 pooled it
0.6field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 2 syntheses or guidelines pooled it, 16 citations in OpenAlex.

  1. Guidelines for authors and reviewers on antibody use in physiology studies.American journal of physiology. Heart and circulatory physiology · 2018
    Guideline
  2. Guidelines for measuring cardiac physiology in mice.American journal of physiology. Heart and circulatory physiology · 2018
    Guideline
  3. Article
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  10. Statistical considerations in reporting cardiovascular research.American journal of physiology. Heart and circulatory physiology · 2018
    Article
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Raymond D DevineDorothy M. Davis Heart and Lung Research Institute, The Ohio State University Wexner Medical Center, Columbus, Ohio.
Sabahattin BicerDivision of Biosciences, College of Dentistry, The Ohio State University, Columbus, Ohio.
Peter J ReiserDivision of Biosciences, College of Dentistry, The Ohio State University, Columbus, Ohio.
Loren E WoldDorothy M. Davis Heart and Lung Research Institute, The Ohio State University Wexner Medical Center, Columbus, Ohio; Loren.Wold@osumc.edu.
The Ohio State University · USThe Ohio State University Wexner Medical Center · US

Funding

Mechanisms of exposure-induced tissue functional and pathological changes in a mouse model of Alzheimer's DiseaseR01AG057046 · NIA · OHIO STATE UNIVERSITY · PI COMBS, COLIN K, DEL MONTE, FEDERICA · 2017 to 2021
$4.0M
Muscle function and depression-like behavior in a mouse model of cancer fatigueR01NR012618 · NINR · OHIO STATE UNIVERSITY · PI REISER, PETER J, WOLD, LOREN EUGENE · 2012 to 2016
$2.2M
Synergistic effects of obesity and air pollution on cardiac functionR01ES019923 · NIEHS · RESEARCH INST NATIONWIDE CHILDREN'S HOSP · PI WOLD, LOREN EUGENE · 2011 to 2015
$1.8M
NIA NIH HHS R01 AG057046NIEHS NIH HHS R01 ES019923NINR NIH HHS R01 NR012618
6 · The paper itself

Abstract

Cancer cachexia is a progressive wasting disease resulting in significant effects on the quality of life and high mortality. Most studies on cancer cachexia have focused on skeletal muscle; however, the heart is now recognized as a major site of cachexia-related effects. To elucidate possible mechanisms, a proteomic study was performed on the left ventricles of colon-26 (C26) adenocarcinoma tumor-bearing mice. The results revealed several changes in proteins involved in metabolism. An integrated pathway analysis of the results revealed a common mediator in hypoxia-inducible factor-1α (HIF-1α). Work by other laboratories has shown that extensive metabolic restructuring in the C26 mouse model causes changes in gene expression that may be affected directly by HIF-1α, such as glucose metabolic genes. M-mode echocardiography showed progressive decline in heart function by

Indexed as

AdenocarcinomaAnimalsCachexiaCell HypoxiaColonic NeoplasmsComputational BiologyDiaphragmFatty Acid-Binding ProteinsFemaleHydroxylationHypoxia-Inducible Factor 1, alpha SubunitHypoxia-Inducible Factor-Proline DioxygenasesMiceMyocardial ContractionMyocardiumNeoplasms, ExperimentalEgln1 protein, mouseFabp4 protein, mouseFatty Acid-Binding ProteinsHif1a protein, mouseHypoxia-Inducible Factor 1, alpha SubunitHypoxia-Inducible Factor-Proline DioxygenasesOxygenProteasome Endopeptidase ComplexProto-Oncogene Proteins c-kitVHL protein, mouseVon Hippel-Lindau Tumor Suppressor Proteincancer cachexiahearthypoxiahypoxia-inducible factorproteomicsskeletal muscle

Identifiers

PMID28341633
PMCPMC5495928
OpenAlexW2599350054

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.