Evidence map›Paper›PMID 28341548›Full record

ArticleDevelopmental biology2017

Cos2/Kif7 and Osm-3/Kif17 regulate onset of outer segment development in zebrafish photoreceptors through distinct mechanisms.

Tylor R Lewis, Sean R Kundinger, Amira L Pavlovich, Jonathan R Bostrom, Brian A Link, Joseph C Besharse

Open access · hybridAbstract read
In one paragraph

Article in Developmental biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
3.1field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 29 citations in OpenAlex.

  1. Kinesins inOpen biology · 2025
    Review
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  8. Biallelic Variants inInternational journal of molecular sciences · 2021
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Tylor R LewisDepartment of Cell Biology, Neurobiology, and Anatomy, Medical College of Wisconsin, Milwaukee, WI 53226, USA.
Sean R KundingerDepartment of Ophthalmology and Visual Sciences, Medical College of Wisconsin, Milwaukee, WI 53226, USA.
Amira L PavlovichDepartment of Ophthalmology and Visual Sciences, Medical College of Wisconsin, Milwaukee, WI 53226, USA.
Jonathan R BostromDepartment of Cell Biology, Neurobiology, and Anatomy, Medical College of Wisconsin, Milwaukee, WI 53226, USA.
Brian A LinkDepartment of Cell Biology, Neurobiology, and Anatomy, Medical College of Wisconsin, Milwaukee, WI 53226, USA.
Joseph C BesharseDepartment of Cell Biology, Neurobiology, and Anatomy, Medical College of Wisconsin, Milwaukee, WI 53226, USA; Department of Ophthalmology and Visual Sciences, Medical College of Wisconsin, Milwaukee, WI 53226, USA. Electronic address: jbeshars@mcw.edu.
Medical College of Wisconsin · US

Funding

MORPHOLOGY MODULEP30EY001931 · NEI · MEDICAL COLLEGE OF WISCONSIN · PI LINK, BRIAN A · 1985 to 2016
$9.8M
VISUAL CELL-PIGMENT CELL INTERFACE AND DISC TURNOVERR01EY003222 · NEI · UNIVERSITY OF KANSAS MEDICAL CENTER · PI BESHARSE, JOSEPH C · 1985 to 2016
$5.0M
Integrative Analysis of Vertebrate Retinal LaminationR01EY014167 · NEI · MEDICAL COLLEGE OF WISCONSIN · PI LINK, BRIAN A · 2003 to 2017
$4.6M
Rresearch Training Program in Vision ScienceT32EY014537 · NEI · MEDICAL COLLEGE OF WISCONSIN · PI Elena V Semina · 2002 to 2026
$4.2M
NEI NIH HHS P30 EY001931NEI NIH HHS R01 EY003222NEI NIH HHS R01 EY014167NEI NIH HHS T32 EY014537
6 · The paper itself

Abstract

Zebrafish morphants of osm-3/kif17, a kinesin-2 family member and intraflagellar transport motor, have photoreceptor outer segments that are dramatically reduced in number and size. However, two genetic mutant lines, osm-3/kif17

Indexed as

MorphogenesisAnimalsBase SequenceCiliaCRISPR-Cas SystemsGene EditingHedgehog ProteinsKinesinsMice, Inbred C57BLModels, BiologicalMorpholinosMutationNeurogenesisRetinal Photoreceptor Cell Outer SegmentSignal TransductionTemperatureHedgehog ProteinsKif17 protein, zebrafishKif7 protein, zebrafishKinesinsMorpholinosTranscription Activator-Like Effector NucleasesZebrafish ProteinsHedgehog signalingIntraflagellar TransportKinesinOuter Segment

Identifiers

PMID28341548
PMCPMC5558849
OpenAlexW2601665674

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.