ReviewSeminars in cell & developmental biology2017
A gene regulatory program controlling early Xenopus mesendoderm formation: Network conservation and motifs.
Review in Seminars in cell & developmental biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- Glycolytic suppression of cell adhesion promotes thyroid morphogenesis in response to nutrition.EMBO reports · 2026Article
- Maternal and zygotic contributions to H3K4me1 chromatin marking during germ layer formation.Developmental biology · 2025Article
- Spatiotemporal requirements of nuclear β-catenin define early sea urchin embryogenesis.PLoS biology · 2024Article
- Computational approaches to understand transcription regulation in development.Biochemical Society transactions · 2023Review
- Quantitative analysis of transcriptome dynamics provides novel insights into developmental state transitions.BMC genomics · 2022Article
- Differential nuclear import sets the timing of protein access to the embryonic genome.Nature communications · 2022Article
- Nodal and <i>churchill1</i> position the expression of a notch ligand during <i>Xenopus</i> germ layer segregation.Life science alliance · 2022Article
- Gain of gene regulatory network interconnectivity at the origin of vertebrates.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Uncovering the mesendoderm gene regulatory network through multi-omic data integration.Cell reports · 2022Article
- Conditional specification of endomesoderm.Cells & development · 2021Review
- Temporal transcriptomic profiling reveals dynamic changes in gene expression of Xenopus animal cap upon activin treatment.Scientific reports · 2021Article
- Cnidarian-bilaterian comparison reveals the ancestral regulatory logic of the β-catenin dependent axial patterning.Nature communications · 2021Article
- Combinatorial transcription factor activities on open chromatin induce embryonic heterogeneity in vertebrates.The EMBO journal · 2021Article
- Segregation of brain and organizer precursors is differentially regulated by Nodal signaling at blastula stage.Biology open · 2021Article
- Control of zygotic genome activation in Xenopus.Current topics in developmental biology · 2021Review
- Sox17 and β-catenin co-occupy Wnt-responsive enhancers to govern the endoderm gene regulatory network.eLife · 2020Article
- Early Xenopus gene regulatory programs, chromatin states, and the role of maternal transcription factors.Current topics in developmental biology · 2020Review
- Genome ofG3 (Bethesda, Md.) · 2019Article
- Endodermal Maternal Transcription Factors Establish Super-Enhancers during Zygotic Genome Activation.Cell reports · 2019Article
- Ventx1.1 competes with a transcriptional activator Xcad2 to regulate negatively its own expression.BMB reports · 2019Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Germ layer formation is among the earliest differentiation events in metazoan embryos. In triploblasts, three germ layers are formed, among which the endoderm gives rise to the epithelial lining of the gut tube and associated organs including the liver, pancreas and lungs. In frogs (Xenopus), where early germ layer formation has been studied extensively, the process of endoderm specification involves the interplay of dozens of transcription factors. Here, we review the interactions between these factors, summarized in a transcriptional gene regulatory network (GRN). We highlight regulatory connections conserved between frog, fish, mouse, and human endodermal lineages. Especially prominent is the conserved role and regulatory targets of the Nodal signaling pathway and the T-box transcription factors, Vegt and Eomes. Additionally, we highlight network topologies and motifs, and speculate on their possible roles in development.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.