ArticleNeuroImage2017
Expectation violation and attention to pain jointly modulate neural gain in somatosensory cortex.
Article in NeuroImage, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 69 citations in OpenAlex.
- The Somatosensory Mismatch Negativity.The European journal of neuroscience · 2025Review
- Thermosensory predictive coding underpins an illusion of pain.Science advances · 2025Article
- Supramodal and modality-specific neural information supports multi-feature prediction errors across cortical levels.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Functional interaction between posterior cerebellar lobes and secondary somatosensory cortex during somatosensory mismatch detection.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Tell me what to expect: how instructions affect the pain response of patients with chronic myofascial pain with referral.Journal of oral & facial pain and headache · 2024Article
- Statistical learning shapes pain perception and prediction independently of external cues.eLife · 2024Article
- A multimodal cortical network of sensory expectation violation revealed by fMRI.Human brain mapping · 2023Article
- EEG mismatch responses in a multimodal roving stimulus paradigm provide evidence for probabilistic inference across audition, somatosensation, and vision.Human brain mapping · 2023Article
- Confidence of probabilistic predictions modulates the cortical response to pain.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Cognitive and affective interaction with somatosensory afference in acupuncture-a specific brain response to compound stimulus.Frontiers in human neuroscience · 2023Article
- Sensory Target Detection at Local and Global Timescales Reveals a Hierarchy of Supramodal Dynamics in the Human Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- In the Body's Eye: The computational anatomy of interoceptive inference.PLoS computational biology · 2022Article
- Be still my heart: Cardiac regulation as a mode of uncertainty reduction.Psychonomic bulletin & review · 2021Article
- Perceptual learning of tone patterns changes the effective connectivity between Heschl's gyrus and planum temporale.Human brain mapping · 2021Article
- Modulations of Insular Projections by Prior Belief Mediate the Precision of Prediction Error during Tactile Learning.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Evaluating the neurophysiological evidence for predictive processing as a model of perception.Annals of the New York Academy of Sciences · 2020Review
- Threat Prediction from Schemas as a Source of Bias in Pain Perception.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- A guide to group effective connectivity analysis, part 2: Second level analysis with PEB.NeuroImage · 2019Article
- Cortical Network Response to Acupuncture and the Effect of the Hegu Point: An fNIRS Study.Sensors (Basel, Switzerland) · 2019Article
- Prior Precision Modulates the Minimization of Auditory Prediction Error.Frontiers in human neuroscience · 2019Article
Corrections and comments
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Authors and funding
6 authors at 5 institutions in 2 countries.
Funding
Abstract
The neural processing and experience of pain are influenced by both expectations and attention. For example, the amplitude of event-related pain responses is enhanced by both novel and unexpected pain, and by moving the focus of attention towards a painful stimulus. Under predictive coding, this congruence can be explained by appeal to a precision-weighting mechanism, which mediates bottom-up and top-down attentional processes by modulating the influence of feedforward and feedback signals throughout the cortical hierarchy. The influence of expectation and attention on pain processing can be mapped onto changes in effective connectivity between or within specific neuronal populations, using a canonical microcircuit (CMC) model of hierarchical processing. We thus implemented a CMC within dynamic causal modelling for magnetoencephalography in human subjects, to investigate how expectation violation and attention to pain modulate intrinsic (within-source) and extrinsic (between-source) connectivity in the somatosensory hierarchy. This enabled us to establish whether both expectancy and attentional processes are mediated by a similar precision-encoding mechanism within a network of somatosensory, frontal and parietal sources. We found that both unexpected and attended pain modulated the gain of superficial pyramidal cells in primary and secondary somatosensory cortex. This modulation occurred in the context of increased lateralized recurrent connectivity between somatosensory and fronto-parietal sources, driven by unexpected painful occurrences. Finally, the strength of effective connectivity parameters in S1, S2 and IFG predicted individual differences in subjective pain modulation ratings. Our findings suggest that neuromodulatory gain control in the somatosensory hierarchy underlies the influence of both expectation violation and attention on cortical processing and pain perception.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.