ArticleBMC complementary and alternative medicine2017
Antibacterial and antibiotic resistance modulatory activities of leaves and bark extracts of Recinodindron heudelotii (Euphorbiaceae) against multidrug-resistant Gram-negative bacteria.
Article in BMC complementary and alternative medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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18 citing papers in PubMed, 41 citations in OpenAlex.
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- In Silico Docking, Resistance Modulation and Biofilm Gene Expression in Multidrug-ResistantAntibiotics (Basel, Switzerland) · 2022Article
- Exploring New Sources of Bioactive Phenolic Compounds from Western Balkan Mountains.Plants (Basel, Switzerland) · 2022Article
- Phytochemical Analysis and Investigation of the Antimicrobial and Cytotoxic Activities ofEvidence-based complementary and alternative medicine : eCAM · 2021Article
- Development and Evaluation of Antimicrobial and Modulatory Activity of Inclusion Complex ofInternational journal of molecular sciences · 2020Article
- Antibacterial and Antibiotic Modifying Potential of Crude Extracts, Fractions, and Compounds fromEvidence-based complementary and alternative medicine : eCAM · 2019Article
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- Antibacterial and Antibiotic-Potentiating Activities of Thirteen Cameroonian Edible Plants against Gram-Negative Resistant Phenotypes.TheScientificWorldJournal · 2018Article
- Antistaphylococcal and Antibiotic Resistance Modulatory Activities of Thirteen Cameroonian Edible Plants against Resistant Phenotypes.International journal of microbiology · 2018Article
- Effect of Fractioning on Antibacterial Activity ofEvidence-based complementary and alternative medicine : eCAM · 2018Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
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Abstract
backgroundRecinodindron heudelotii (Euphorbiaceae) is a plant used in Africa, particularly in Cameroon to treat various ailments including bacterial infections. In this study, we evaluated the extracts of the leaves (RHL) and bark (RHB) of R. heudelotii for their antibacterial and antibiotic resistance modulating activities against 29 Gram-negative bacteria, including multidrug-resistant (MDR) phenotypes.
methodsThe broth micro-dilution assay was used to evaluate the antibacterial activity, and the antibiotic resistance modulating effects of the plant extracts.
resultsRHL displayed the most important spectrum of activity with minimal inhibitory concentrations (MICs) values ranging from 256 to 1024 μg/mL against 75.86% of the 29 tested bacteria strains while RHB was not active. RHL also showed killing effects with minimal bactericidal concentrations (MBCs) ranging from 256 to 1024 μg/mL. The activities of tetracycline and kanamycin associated with RHL were improved on 88.89% and 77.78% of the tested MDR bacteria, at MIC/2 at MIC/4 respectively, with 2 to 16-folds decreasing of MIC. This suggests the antibiotic resistance modulating effects of these antibiotics.
conclusionThe present study provides data indicating a possible use of the leaves extract of Recinodindron heudelotii alone or in association with common antibiotics in the fight against bacterial infections including those involving MDR bacteria.
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