Evidence map›Paper›PMID 28340606›Full record

ArticleBMC research notes2017

Validating a self-report measure of HIV viral suppression: an analysis of linked questionnaire and clinical data from the Canadian HIV Women's Sexual and Reproductive Health Cohort Study.

Allison Carter, Alexandra de Pokomandy, Mona Loutfy, Erin Ding, Paul Sereda, Kath Webster, Valerie Nicholson, Kerrigan Beaver, Robert S Hogg, Angela Kaida and 1 more

Abstract readMulticenter StudyValidation Study
In one paragraph

Article in BMC research notes, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

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  12. Transition from Pediatric to Adult HIV Care for Young Women Living with HIV.Journal of the International Association of Providers of AIDS Care
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Allison CarterFaculty of Health Sciences, Simon Fraser University, Burnaby, BC, Canada.
Alexandra de PokomandyChronic Viral Illness Service, McGill University Health Centre, Montreal, QC, Canada.
Mona LoutfyWomen's College Research Institute, Women's College Hospital, Toronto, ON, Canada.
Erin DingEpidemiology and Population Health Program, British Columbia Centre for Excellence in HIV/AIDS, Vancouver, BC, Canada.
Paul SeredaEpidemiology and Population Health Program, British Columbia Centre for Excellence in HIV/AIDS, Vancouver, BC, Canada.
Kath WebsterFaculty of Health Sciences, Simon Fraser University, Burnaby, BC, Canada.
Valerie NicholsonFaculty of Health Sciences, Simon Fraser University, Burnaby, BC, Canada.
Kerrigan BeaverWomen's College Research Institute, Women's College Hospital, Toronto, ON, Canada.
Robert S HoggFaculty of Health Sciences, Simon Fraser University, Burnaby, BC, Canada.
Angela KaidaFaculty of Health Sciences, Simon Fraser University, Burnaby, BC, Canada. kangela@sfu.ca.
CHIWOS Research Team

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundWe assessed the validity of a self-report measure of undetectable viral load (VL) among women with HIV in British Columbia (BC), Canada. Questionnaire data from the Canadian HIV Women's Sexual and Reproductive Health Cohort Study was linked with population-based clinical data from the BC Centre for Excellence in HIV/AIDS. Self-reported undetectable VL was assessed by the question: "What was your most recent VL, undetectable (i.e. <50 copies/mL) or detectable (i.e. ≥50 copies/mL)?" Laboratory measurements of VL <50 copies/mL (closest to/before study visit) were the criterion for validity analyses. We measured positive and negative predictive values (PPV, NPV) and likelihood ratios (LR+, LR-).

resultsOf 356 participants, 99% were linked to clinical data. Those unlinked (n = 1), missing self-report VL (n = 18), or missing self-report and laboratory VL (n = 1) were excluded. Among the remaining 336: median age was 44 (IQR 37-51); 96% identified as cis-gender; 84% identified as heterosexual; and 45% identified as Indigenous, 40% White, 8% African, Caribbean, or Black, and 8% other/multiple ethnicities. Overall, 85% self-reported having an undetectable VL while 82% had clinical data indicating viral suppression. The PPV was 93.7 (95% CI 90.2-96.2) indicating that 94% of women who self-reported being undetectable truly were. The NPV was 80.4 (95% CI 66.9-90.2). LR+ was 3.2 (2.1-4.6) and LR- was 0.05 (0.03-0.10).

conclusionsOur self-report measure assessing undetectable VL strongly predicted true viral suppression among Canadian women with HIV. This measure can be used in research settings without laboratory data in regions with high rates of VL testing and suppression.

Indexed as

AdultAnti-HIV AgentsBritish ColumbiaCanadaCohort StudiesFemaleHIV-1HIV InfectionsHost-Pathogen InteractionsHumansMiddle AgedReproducibility of ResultsReproductive HealthSelf ReportSexual BehaviorViral LoadAnti-HIV AgentsCanadaCHIWOSHIVValidationViral suppressionWomen

Identifiers

PMID28340606
PMCPMC5366109

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.