ArticleMicrobiome2017
Temporal dynamics of the gut microbiota in people sharing a confined environment, a 520-day ground-based space simulation, MARS500.
Article in Microbiome, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 71 papers.
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Who cites it
71 citing papers in PubMed.
- Sex and social group altered the gut microbiome and fecal metabolome in the critically endangered Yangtze finless porpoise (Current zoology · 2026Article
- Gut microbiota profiling of the population residing in Friuli-Venezia Giulia through next-generation sequencing.BMC microbiology · 2026Article
- Biofilms: from the cradle of life to life support.NPJ biofilms and microbiomes · 2026Review
- Human Microbiome Alterations in Antarctic Isolated, Confined, and Extreme (ICE) Environments: A Systematic Review and Meta-Regression.International journal of microbiology · 2026Review
- Microbiome stewardship: definition and guiding principles for implementation.Sustainable microbiology · 2026Article
- Integrative artificial intelligence and multi-omics modeling approach for characterizing microbial dynamics and health impacts in space microgravity and radiation conditions.Frontiers in microbiology · 2026Article
- Case Study on Shifts in Human Skin Microbiome During Antarctica Expeditions.Microorganisms · 2025Article
- Navigating mental health in space: gut-brain axis and microbiome dynamics.Experimental & molecular medicine · 2025Review
- Effects of Different Levels of Flea Infestation on Gut Microbiota of Brandt's Voles (Animals : an open access journal from MDPI · 2025Article
- An interdisciplinary perspective of the built-environment microbiome.FEMS microbiology ecology · 2025Review
- Challenges for the human immune system after leaving Earth.NPJ microgravity · 2024Review
- Eubacterium siraeum suppresses fat deposition via decreasing the tyrosine-mediated PI3K/AKT signaling pathway in high-fat diet-induced obesity.Microbiome · 2024Article
- Article
- Evaluation of inter- and intra-variability in gut health markers in healthy adults using an optimised faecal sampling and processing method.Scientific reports · 2024Article
- Gut matters in microgravity: potential link of gut microbiota and its metabolites to cardiovascular and musculoskeletal well-being.Nutrition & metabolism · 2024Review
- Group membership, not diet, structures the composition and functional potential of the gut microbiome in a wild primate.mSphere · 2024Article
- Influence of gut microbiome on metabolic diseases: a new perspective based on microgravity.Journal of diabetes and metabolic disorders · 2024Review
- Long-term space missions' effects on the human organism: what we do know and what requires further research.Frontiers in physiology · 2024Review
- Simulated spaceflight-induced cardiac remodeling is modulated by gut microbial-derived trimethylamine N-oxide.iScience · 2023Article
- Effects of 60 days of 6° head-down bed rest on the composition and function of the human gut microbiota.iScience · 2023Article
11 more citing papers are in PubMed but not listed here.
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Authors and funding
14 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe intestinal microbial communities and their temporal dynamics are gaining increasing interest due to the significant implications for human health. Recent studies have shown the dynamic behavior of the gut microbiota in free-living, healthy persons. To date, it is not known whether these dynamics are applicable during prolonged life sharing in a confined and controlled environment.
resultsThe MARS500 project, the longest ground-based space simulation ever, provided us with a unique opportunity to trace the crew microbiota over 520 days of isolated confinement, such as that faced by astronauts in real long-term interplanetary space flights, and after returning to regular life, for a total of 2 years. According to our data, even under the strictly controlled conditions of an enclosed environment, the human gut microbiota is inherently dynamic, capable of shifting between different steady states, typically with rearrangements of autochthonous members. Notwithstanding a strong individuality in the overall gut microbiota trajectory, some key microbial components showed conserved temporal dynamics, with potential implications for the maintenance of a health-promoting, mutualistic microbiota configuration.
conclusionsSharing life in a confined habitat does not affect the resilience of the individual gut microbial ecosystem, even in the long term. However, the temporal dynamics of certain microbiota components should be monitored when programming future mission simulations and real space flights, to prevent breakdowns in the metabolic and immunological homeostasis of the crewmembers.
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