Evidence map›Paper›PMID 28340512›Full record

ArticleProtein science : a publication of the Protein Society2017

Activation mechanisms of αVβ3 integrin by binding to fibronectin: A computational study.

Lingyun Wang, Di Pan, Qi Yan, Yuhua Song

Open access · bronzeAbstract read
In one paragraph

Article in Protein science : a publication of the Protein Society, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.7field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 29 citations in OpenAlex.

  1. Article
  2. MnBiophysical journal · 2025
    Article
  3. Interaction of integrin αFrontiers in cell and developmental biology · 2025
    Article
  4. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Lingyun WangDepartment of Biomedical Engineering, The University of Alabama at Birmingham, Birmingham, Alabama, 35294.
Di PanDepartment of Biomedical Engineering, The University of Alabama at Birmingham, Birmingham, Alabama, 35294.
Qi YanDepartment of Biomedical Engineering, The University of Alabama at Birmingham, Birmingham, Alabama, 35294.
Yuhua SongDepartment of Biomedical Engineering, The University of Alabama at Birmingham, Birmingham, Alabama, 35294.
University of Alabama at Birmingham · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Integrin αVβ3 plays an important role in regulating cellular activities and in human diseases. Although the structure of αVβ3 has been studied by crystallography and electron microscopy, the detailed activation mechanism of integrin αVβ3 induced by fibronectin remains unclear. In this study, we investigated the conformational and dynamical motion changes of Mn

Indexed as

Computer SimulationMolecular Dynamics SimulationFibronectinsHumansIntegrin alphaVbeta3Protein BindingProtein Structure, QuaternaryFibronectinsIntegrin alphaVbeta3activation mechanismconformational and dynamical motion changesfibronectinintegrin αVβ3molecular dynamics simulation

Identifiers

PMID28340512
PMCPMC5441423
OpenAlexW2060487501

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.