ArticleJournal of the American Medical Informatics Association : JAMIA2017
Pragmatic (trial) informatics: a perspective from the NIH Health Care Systems Research Collaboratory.
Article in Journal of the American Medical Informatics Association : JAMIA, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed.
- Pragmatic approaches for studying workflow in health informatics.JAMIA open · 2026Review
- Ethical considerations for sharing aggregate results from pragmatic clinical trials.Clinical trials (London, England) · 2025Article
- Impact of electronic health record updates and changes on the delivery and monitoring of interventions in embedded pragmatic clinical trials.Contemporary clinical trials · 2025Article
- Clinical Research Informatics: a Decade-in-Review.Yearbook of medical informatics · 2024Review
- Computable phenotype for real-world, data-driven retrospective identification of relapse in ANCA-associated vasculitis.RMD open · 2024Article
- Career development in pragmatic clinical trials to improve care for people living with dementia.Journal of the American Geriatrics Society · 2023Article
- Learning health system, positive deviance analysis, and electronic health records: Synergy for a learning health system.Learning health systems · 2023Article
- Dementia and electronic health record phenotypes: a scoping review of available phenotypes and opportunities for future research.Journal of the American Medical Informatics Association : JAMIA · 2023Article
- Catalyzing dementia care through the learning health system and consumer health information technology.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2023Article
- Maturity in enterprise data warehouses for research operations: Analysis of a pilot study.Journal of clinical and translational science · 2023Article
- Enhancing the use of EHR systems for pragmatic embedded research: lessons from the NIH Health Care Systems Research Collaboratory.Journal of the American Medical Informatics Association : JAMIA · 2021Article
- Electronic Health Records-Based Cardio-Oncology Registry for Care Gap Identification and Pragmatic Research: Procedure and Observational Study.JMIR cardio · 2021Article
- Learning health systems, embedded research, and data standards-recommendations for healthcare system leaders.JAMIA open · 2020Review
- Computable Phenotype Implementation for a National, Multicenter Pragmatic Clinical Trial: Lessons Learned From ADAPTABLE.Circulation. Cardiovascular quality and outcomes · 2020Article
- Polar labeling: silver standard algorithm for training disease classifiers.Bioinformatics (Oxford, England) · 2020Article
- Article
- User stories as lightweight requirements for agile clinical decision support development.Journal of the American Medical Informatics Association : JAMIA · 2019Article
- Identifying Opioid Use Disorder in the Emergency Department: Multi-System Electronic Health Record-Based Computable Phenotype Derivation and Validation Study.JMIR medical informatics · 2019Article
- Improving the promise of embedded pragmatic trials: Surmountable barriers encountered in an evaluation of home-based HPV self-sampling to increase cervical cancer screening in overdue women.Contemporary clinical trials communications · 2019Article
- Phenotyping to Facilitate Accrual for a Cardiovascular Intervention.Journal of clinical medicine research · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors.
Funding
Abstract
Pragmatic clinical trials (PCTs) are research investigations embedded in health care settings designed to increase the efficiency of research and its relevance to clinical practice. The Health Care Systems Research Collaboratory, initiated by the National Institutes of Health Common Fund in 2010, is a pioneering cooperative aimed at identifying and overcoming operational challenges to pragmatic research. Drawing from our experience, we present 4 broad categories of informatics-related challenges: (1) using clinical data for research, (2) integrating data from heterogeneous systems, (3) using electronic health records to support intervention delivery or health system change, and (4) assessing and improving data capture to define study populations and outcomes. These challenges impact the validity, reliability, and integrity of PCTs. Achieving the full potential of PCTs and a learning health system will require meaningful partnerships between health system leadership and operations, and federally driven standards and policies to ensure that future electronic health record systems have the flexibility to support research.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.