Evidence map›Paper›PMID 28340175›Full record

ArticleMedical mycology2018

FunResDB-A web resource for genotypic susceptibility testing of Aspergillus fumigatus.

Michael Weber, Jonas Schaer, Grit Walther, Kerstin Kaerger, Jörg Steinmann, Peter-Michael Rath, Birgit Spiess, Dieter Buchheidt, Axel Hamprecht, Oliver Kurzai

Open access · hybridAbstract read
In one paragraph

Article in Medical mycology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.5field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 24 citations in OpenAlex.

  1. Review
  2. Azole Resistance inOpen forum infectious diseases · 2026
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  3. Article
  4. Review
  5. Article
  6. Triazole resistance inApplied and environmental microbiology · 2024
    Article
  7. Article
  8. Article
  9. Azole Resistance andJournal of fungi (Basel, Switzerland) · 2022
    Article
  10. Observational
  11. Antimicrobial agents and chemotherapy · 2019
    Article
  12. (New) Methods for Detection ofCurrent fungal infection reports · 2019
    Article
  13. MARDy: Mycology Antifungal Resistance Database.Bioinformatics (Oxford, England) · 2018
    Article
  14. Article
  15. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Michael WeberGerman National Reference Center for Invasive Fungal Infections - NRZMyk, Septomics Research Centre, Leibniz-Institute for Natural Product Research and Infection Biology - Hans-Knoell-Institute, 07745 Jena, Germany.
Jonas SchaerGerman National Reference Center for Invasive Fungal Infections - NRZMyk, Septomics Research Centre, Leibniz-Institute for Natural Product Research and Infection Biology - Hans-Knoell-Institute, 07745 Jena, Germany.
Grit WaltherGerman National Reference Center for Invasive Fungal Infections - NRZMyk, Septomics Research Centre, Leibniz-Institute for Natural Product Research and Infection Biology - Hans-Knoell-Institute, 07745 Jena, Germany.
Kerstin KaergerGerman National Reference Center for Invasive Fungal Infections - NRZMyk, Septomics Research Centre, Leibniz-Institute for Natural Product Research and Infection Biology - Hans-Knoell-Institute, 07745 Jena, Germany.
Jörg SteinmannInstitute of Medical Microbiology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
Peter-Michael RathInstitute of Medical Microbiology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
Birgit SpiessDepartment of Hematology and Oncology, Mannheim University Hospital, University of Heidelberg, Mannheim, Germany.
Dieter BuchheidtDepartment of Hematology and Oncology, Mannheim University Hospital, University of Heidelberg, Mannheim, Germany.
Axel HamprechtInstitute for Medical Microbiology, Immunology and Hygiene, University of Cologne, Cologne, Germany German Centre for Infection Research (DZIF), Partner Site Bonn-Cologne, Cologne, Germany.
Oliver KurzaiGerman National Reference Center for Invasive Fungal Infections - NRZMyk, Septomics Research Centre, Leibniz-Institute for Natural Product Research and Infection Biology - Hans-Knoell-Institute, 07745 Jena, Germany.
Leibniz-Institut für Naturstoff-Forschung und Infektionsbiologie e. V. - Hans-Knöll-Institut (HKI) · DEUniversity Hospital Heidelberg · DEUniversity of Duisburg-Essen · DEUniversity of Cologne · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Therapy of invasive aspergillosis is becoming more difficult due to the emergence of azole resistance in Aspergillus fumigatus. A majority of resistant strains carries mutations in the CYP51A gene. Due to a lack of sensitivity of culture-based methods, molecular detection of A. fumigatus has become an important diagnostic tool. We set up the database FunResDB (www.nrz-myk.de/funresdb) to gather all available information about CYP51A-dependent azole resistance from published literature. In summary, the screening resulted in 79 CYP51A variants, which are linked to 59 nonsynonymous mutations. A tailor-made online sequence analysis tool allows for genotypic susceptibility testing of A. fumigatus.

Indexed as

Databases, GeneticInternetAllelesAntifungal AgentsAspergillus fumigatusAzolesCytochrome P-450 Enzyme SystemFungal ProteinsGenotypeGenotyping TechniquesHumansMicrobial Sensitivity TestsPolymorphism, GeneticAntifungal AgentsAzolescytochrome P-450 CYP51A, AspergillusCytochrome P-450 Enzyme SystemFungal ProteinsAspergillus fumigatusdatabasedrug susceptibilityfungal infectiontriazoles

Identifiers

PMID28340175
PMCPMC5896429
OpenAlexW2594084827

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.