ArticleNeuro-oncology2017
Repositioning disulfiram as a radiosensitizer against atypical teratoid/rhabdoid tumor.
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Article in Neuro-oncology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15citing papers in PubMed
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Who cites it
15 citing papers in PubMed, 24 citations in OpenAlex.
- Off-label and repurposed use of disulfiram beyond alcohol dependence: A systematic review of clinical and preclinical evidence.iScience · 2026Article
- Compound Library Screening Identified Cladribine as a Novel Radiosensitizer for Prostate Cancer.Cancer science · 2026Article
- Ferroptosis: Frenemy of Radiotherapy.International journal of molecular sciences · 2024Review
- SMARCB1 Gene Therapy Using a Novel Tumor-Targeted Nanomedicine Enhances Anti-Cancer Efficacy in a Mouse Model of Atypical Teratoid Rhabdoid Tumors.International journal of nanomedicine · 2024Article
- Current and Emerging Therapeutic Approaches for Extracranial Malignant Rhabdoid Tumors.Cancer management and research · 2022Review
- Disulfiram in glioma: Literature review of drug repurposing.Frontiers in pharmacology · 2022Review
- Repurposing Disulfiram for Targeting of Glioblastoma Stem Cells: An In Vitro Study.Biomolecules · 2021Article
- Disulfiram and copper combination therapy targets NPL4, cancer stem cells and extends survival in a medulloblastoma model.PloS one · 2021Article
- Overview of AntabuseCancer management and research · 2021Review
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- Disulfiram Chelated With Copper Inhibits the Growth of Gastric Cancer Cells by Modulating Stress Response and Wnt/β-catenin Signaling.Frontiers in oncology · 2020Article
- The Evolving Role of Disulfiram in Radiobiology and the Treatment of Breast Cancer.OncoTargets and therapy · 2020Review
- Panobinostat, a histone deacetylase inhibitor, rescues the angiogenic potential of endothelial colony-forming cells in moyamoya disease.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2019Article
- Disulfiram, a Re-positioned Aldehyde Dehydrogenase Inhibitor, Enhances Radiosensitivity of Human Glioblastoma Cells In Vitro.Cancer research and treatment · 2019Article
- Formulation Comprising Arsenic Trioxide and Dimercaprol Enhances Radiosensitivity of Pancreatic Cancer Xenografts.Technology in cancer research & treatmentArticle
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Authors and funding
14 authors at 6 institutions in 2 countries.
Young Eun LeeDivision of Pediatric Neurosurgery, Pediatric Clinical Neuroscience Center, Seoul National University Children's Hospital, Seoul National University College of Medicine, Seoul, South Korea; Adolescent Cancer Center, Seoul National University Cancer Hospital, Seoul, South Korea; Department of Radiation Oncology, Seoul National University Hospital, Seoul, South Korea; Department of Anatomy, Seoul National University College of Medicine, Seoul, South Korea; Department of Pathology, Seoul National University College of Medicine, Seoul, South Korea; Department of Pediatrics, Seoul National University Children's Hospital, Seoul, South Korea; Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, South Korea; Department of Health Science and Technology, Samsung Advanced Institute for Health Sciences and Technology, SungKyunKwan University, Seoul, South Korea; Department of Anatomy and Cell Biology, SungKyunKwan University School of Medicine, Suwon, South Korea; Single Cell Network Research Center, Sungkyunkwan University School of Medicine, Suwon, South Korea.
Seung Ah ChoiDivision of Pediatric Neurosurgery, Pediatric Clinical Neuroscience Center, Seoul National University Children's Hospital, Seoul National University College of Medicine, Seoul, South Korea; Adolescent Cancer Center, Seoul National University Cancer Hospital, Seoul, South Korea; Department of Radiation Oncology, Seoul National University Hospital, Seoul, South Korea; Department of Anatomy, Seoul National University College of Medicine, Seoul, South Korea; Department of Pathology, Seoul National University College of Medicine, Seoul, South Korea; Department of Pediatrics, Seoul National University Children's Hospital, Seoul, South Korea; Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, South Korea; Department of Health Science and Technology, Samsung Advanced Institute for Health Sciences and Technology, SungKyunKwan University, Seoul, South Korea; Department of Anatomy and Cell Biology, SungKyunKwan University School of Medicine, Suwon, South Korea; Single Cell Network Research Center, Sungkyunkwan University School of Medicine, Suwon, South Korea.
Pil Ae KwackDivision of Pediatric Neurosurgery, Pediatric Clinical Neuroscience Center, Seoul National University Children's Hospital, Seoul National University College of Medicine, Seoul, South Korea; Adolescent Cancer Center, Seoul National University Cancer Hospital, Seoul, South Korea; Department of Radiation Oncology, Seoul National University Hospital, Seoul, South Korea; Department of Anatomy, Seoul National University College of Medicine, Seoul, South Korea; Department of Pathology, Seoul National University College of Medicine, Seoul, South Korea; Department of Pediatrics, Seoul National University Children's Hospital, Seoul, South Korea; Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, South Korea; Department of Health Science and Technology, Samsung Advanced Institute for Health Sciences and Technology, SungKyunKwan University, Seoul, South Korea; Department of Anatomy and Cell Biology, SungKyunKwan University School of Medicine, Suwon, South Korea; Single Cell Network Research Center, Sungkyunkwan University School of Medicine, Suwon, South Korea.
Hak Jae KimDivision of Pediatric Neurosurgery, Pediatric Clinical Neuroscience Center, Seoul National University Children's Hospital, Seoul National University College of Medicine, Seoul, South Korea; Adolescent Cancer Center, Seoul National University Cancer Hospital, Seoul, South Korea; Department of Radiation Oncology, Seoul National University Hospital, Seoul, South Korea; Department of Anatomy, Seoul National University College of Medicine, Seoul, South Korea; Department of Pathology, Seoul National University College of Medicine, Seoul, South Korea; Department of Pediatrics, Seoul National University Children's Hospital, Seoul, South Korea; Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, South Korea; Department of Health Science and Technology, Samsung Advanced Institute for Health Sciences and Technology, SungKyunKwan University, Seoul, South Korea; Department of Anatomy and Cell Biology, SungKyunKwan University School of Medicine, Suwon, South Korea; Single Cell Network Research Center, Sungkyunkwan University School of Medicine, Suwon, South Korea.
Il Han KimDivision of Pediatric Neurosurgery, Pediatric Clinical Neuroscience Center, Seoul National University Children's Hospital, Seoul National University College of Medicine, Seoul, South Korea; Adolescent Cancer Center, Seoul National University Cancer Hospital, Seoul, South Korea; Department of Radiation Oncology, Seoul National University Hospital, Seoul, South Korea; Department of Anatomy, Seoul National University College of Medicine, Seoul, South Korea; Department of Pathology, Seoul National University College of Medicine, Seoul, South Korea; Department of Pediatrics, Seoul National University Children's Hospital, Seoul, South Korea; Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, South Korea; Department of Health Science and Technology, Samsung Advanced Institute for Health Sciences and Technology, SungKyunKwan University, Seoul, South Korea; Department of Anatomy and Cell Biology, SungKyunKwan University School of Medicine, Suwon, South Korea; Single Cell Network Research Center, Sungkyunkwan University School of Medicine, Suwon, South Korea.
Kyu-Chang WangDivision of Pediatric Neurosurgery, Pediatric Clinical Neuroscience Center, Seoul National University Children's Hospital, Seoul National University College of Medicine, Seoul, South Korea; Adolescent Cancer Center, Seoul National University Cancer Hospital, Seoul, South Korea; Department of Radiation Oncology, Seoul National University Hospital, Seoul, South Korea; Department of Anatomy, Seoul National University College of Medicine, Seoul, South Korea; Department of Pathology, Seoul National University College of Medicine, Seoul, South Korea; Department of Pediatrics, Seoul National University Children's Hospital, Seoul, South Korea; Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, South Korea; Department of Health Science and Technology, Samsung Advanced Institute for Health Sciences and Technology, SungKyunKwan University, Seoul, South Korea; Department of Anatomy and Cell Biology, SungKyunKwan University School of Medicine, Suwon, South Korea; Single Cell Network Research Center, Sungkyunkwan University School of Medicine, Suwon, South Korea.
Ji Hoon PhiDivision of Pediatric Neurosurgery, Pediatric Clinical Neuroscience Center, Seoul National University Children's Hospital, Seoul National University College of Medicine, Seoul, South Korea; Adolescent Cancer Center, Seoul National University Cancer Hospital, Seoul, South Korea; Department of Radiation Oncology, Seoul National University Hospital, Seoul, South Korea; Department of Anatomy, Seoul National University College of Medicine, Seoul, South Korea; Department of Pathology, Seoul National University College of Medicine, Seoul, South Korea; Department of Pediatrics, Seoul National University Children's Hospital, Seoul, South Korea; Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, South Korea; Department of Health Science and Technology, Samsung Advanced Institute for Health Sciences and Technology, SungKyunKwan University, Seoul, South Korea; Department of Anatomy and Cell Biology, SungKyunKwan University School of Medicine, Suwon, South Korea; Single Cell Network Research Center, Sungkyunkwan University School of Medicine, Suwon, South Korea.
Ji Yeoun LeeDivision of Pediatric Neurosurgery, Pediatric Clinical Neuroscience Center, Seoul National University Children's Hospital, Seoul National University College of Medicine, Seoul, South Korea; Adolescent Cancer Center, Seoul National University Cancer Hospital, Seoul, South Korea; Department of Radiation Oncology, Seoul National University Hospital, Seoul, South Korea; Department of Anatomy, Seoul National University College of Medicine, Seoul, South Korea; Department of Pathology, Seoul National University College of Medicine, Seoul, South Korea; Department of Pediatrics, Seoul National University Children's Hospital, Seoul, South Korea; Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, South Korea; Department of Health Science and Technology, Samsung Advanced Institute for Health Sciences and Technology, SungKyunKwan University, Seoul, South Korea; Department of Anatomy and Cell Biology, SungKyunKwan University School of Medicine, Suwon, South Korea; Single Cell Network Research Center, Sungkyunkwan University School of Medicine, Suwon, South Korea.
Sangjoon ChongDivision of Pediatric Neurosurgery, Pediatric Clinical Neuroscience Center, Seoul National University Children's Hospital, Seoul National University College of Medicine, Seoul, South Korea; Adolescent Cancer Center, Seoul National University Cancer Hospital, Seoul, South Korea; Department of Radiation Oncology, Seoul National University Hospital, Seoul, South Korea; Department of Anatomy, Seoul National University College of Medicine, Seoul, South Korea; Department of Pathology, Seoul National University College of Medicine, Seoul, South Korea; Department of Pediatrics, Seoul National University Children's Hospital, Seoul, South Korea; Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, South Korea; Department of Health Science and Technology, Samsung Advanced Institute for Health Sciences and Technology, SungKyunKwan University, Seoul, South Korea; Department of Anatomy and Cell Biology, SungKyunKwan University School of Medicine, Suwon, South Korea; Single Cell Network Research Center, Sungkyunkwan University School of Medicine, Suwon, South Korea.
Sung-Hye ParkDivision of Pediatric Neurosurgery, Pediatric Clinical Neuroscience Center, Seoul National University Children's Hospital, Seoul National University College of Medicine, Seoul, South Korea; Adolescent Cancer Center, Seoul National University Cancer Hospital, Seoul, South Korea; Department of Radiation Oncology, Seoul National University Hospital, Seoul, South Korea; Department of Anatomy, Seoul National University College of Medicine, Seoul, South Korea; Department of Pathology, Seoul National University College of Medicine, Seoul, South Korea; Department of Pediatrics, Seoul National University Children's Hospital, Seoul, South Korea; Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, South Korea; Department of Health Science and Technology, Samsung Advanced Institute for Health Sciences and Technology, SungKyunKwan University, Seoul, South Korea; Department of Anatomy and Cell Biology, SungKyunKwan University School of Medicine, Suwon, South Korea; Single Cell Network Research Center, Sungkyunkwan University School of Medicine, Suwon, South Korea.
Kyung Duk ParkDivision of Pediatric Neurosurgery, Pediatric Clinical Neuroscience Center, Seoul National University Children's Hospital, Seoul National University College of Medicine, Seoul, South Korea; Adolescent Cancer Center, Seoul National University Cancer Hospital, Seoul, South Korea; Department of Radiation Oncology, Seoul National University Hospital, Seoul, South Korea; Department of Anatomy, Seoul National University College of Medicine, Seoul, South Korea; Department of Pathology, Seoul National University College of Medicine, Seoul, South Korea; Department of Pediatrics, Seoul National University Children's Hospital, Seoul, South Korea; Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, South Korea; Department of Health Science and Technology, Samsung Advanced Institute for Health Sciences and Technology, SungKyunKwan University, Seoul, South Korea; Department of Anatomy and Cell Biology, SungKyunKwan University School of Medicine, Suwon, South Korea; Single Cell Network Research Center, Sungkyunkwan University School of Medicine, Suwon, South Korea.
Do Won HwangDivision of Pediatric Neurosurgery, Pediatric Clinical Neuroscience Center, Seoul National University Children's Hospital, Seoul National University College of Medicine, Seoul, South Korea; Adolescent Cancer Center, Seoul National University Cancer Hospital, Seoul, South Korea; Department of Radiation Oncology, Seoul National University Hospital, Seoul, South Korea; Department of Anatomy, Seoul National University College of Medicine, Seoul, South Korea; Department of Pathology, Seoul National University College of Medicine, Seoul, South Korea; Department of Pediatrics, Seoul National University Children's Hospital, Seoul, South Korea; Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, South Korea; Department of Health Science and Technology, Samsung Advanced Institute for Health Sciences and Technology, SungKyunKwan University, Seoul, South Korea; Department of Anatomy and Cell Biology, SungKyunKwan University School of Medicine, Suwon, South Korea; Single Cell Network Research Center, Sungkyunkwan University School of Medicine, Suwon, South Korea.
Kyeung Min JooDivision of Pediatric Neurosurgery, Pediatric Clinical Neuroscience Center, Seoul National University Children's Hospital, Seoul National University College of Medicine, Seoul, South Korea; Adolescent Cancer Center, Seoul National University Cancer Hospital, Seoul, South Korea; Department of Radiation Oncology, Seoul National University Hospital, Seoul, South Korea; Department of Anatomy, Seoul National University College of Medicine, Seoul, South Korea; Department of Pathology, Seoul National University College of Medicine, Seoul, South Korea; Department of Pediatrics, Seoul National University Children's Hospital, Seoul, South Korea; Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, South Korea; Department of Health Science and Technology, Samsung Advanced Institute for Health Sciences and Technology, SungKyunKwan University, Seoul, South Korea; Department of Anatomy and Cell Biology, SungKyunKwan University School of Medicine, Suwon, South Korea; Single Cell Network Research Center, Sungkyunkwan University School of Medicine, Suwon, South Korea.
Seung-Ki KimDivision of Pediatric Neurosurgery, Pediatric Clinical Neuroscience Center, Seoul National University Children's Hospital, Seoul National University College of Medicine, Seoul, South Korea; Adolescent Cancer Center, Seoul National University Cancer Hospital, Seoul, South Korea; Department of Radiation Oncology, Seoul National University Hospital, Seoul, South Korea; Department of Anatomy, Seoul National University College of Medicine, Seoul, South Korea; Department of Pathology, Seoul National University College of Medicine, Seoul, South Korea; Department of Pediatrics, Seoul National University Children's Hospital, Seoul, South Korea; Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, South Korea; Department of Health Science and Technology, Samsung Advanced Institute for Health Sciences and Technology, SungKyunKwan University, Seoul, South Korea; Department of Anatomy and Cell Biology, SungKyunKwan University School of Medicine, Suwon, South Korea; Single Cell Network Research Center, Sungkyunkwan University School of Medicine, Suwon, South Korea.
Seoul National University · KRSeoul National University Children's Hospital · KRNational University College · PRSamsung (South Korea) · KRSeoul National University Hospital · KRSungkyunkwan University · KR
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAtypical teratoid/rhabdoid tumor (AT/RT) is one of the most common malignant brain tumors in infants. Although cancer stem cells of AT/RT express aldehyde dehydrogenase (ALDH), effective chemotherapies against AT/RT have not been established. Here, we examined radiosensitizing effects of disulfiram (DSF), an irreversible inhibitor of ALDH against AT/RT for a novel therapeutic method.
methodsPatient-derived primary cultured AT/RT cells (SNU.AT/RT-5 and SNU.AT/RT-6) and established AT/RT cell lines (BT-12 and BT-16) were used to assess therapeutic effects of combining DSF with radiation treatment (RT). Survival fraction by clonogenic assay, protein expression, immunofluorescence, and autophagy analysis were evaluated in vitro. Antitumor effects of combining DSF with RT were verified by bioluminescence imaging, tumor volume, and survival analysis in vivo.
resultsThe results demonstrated that DSF at low concentration enhanced the radiosensitivity of AT/RT cells with reduction of survival fraction to 1.21‒1.58. DSF increased DNA double-strand break (γ-H2AX, p-DNA-PKcs, and p-ATM), apoptosis (cleaved caspase-3), autophagy (LC3B), and cell cycle arrest (p21) in irradiated AT/RT cells, while it decreased anti-apoptosis (nuclear factor-kappaB, Survivin, and B-cell lymphoma 2 [Bcl2]). In vivo, DSF and RT combined treatment significantly reduced tumor volumes and prolonged the survival of AT/RT mouse models compared with single treatments. The combined treatment also increased γ-H2AX, cleaved caspase-3, and LC3B expression and decreased ALDH1, Survivin, and Bcl2 expression in vivo.
conclusionsDSF and RT combination therapy has additive therapeutic effects on AT/RT by potentiating programmed cell death, including apoptosis and autophagy of AT/RT cells. We suggest that DSF can be applied as a radiosensitizer in AT/RT treatment.
Indexed as
AnimalsApoptosisBrain NeoplasmsCell Cycle CheckpointsCell ProliferationDisulfiramHumansInfantMaleMiceNeoplastic Stem CellsRadiation-Sensitizing AgentsRadiation ToleranceRhabdoid TumorTeratomaXenograft Model Antitumor AssaysDisulfiramRadiation-Sensitizing AgentsAT/RTDNA damageDSFradiation therapyradiosensitizer
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