ArticleJournal of the Pediatric Infectious Diseases Society2018
Incidence and Outcomes of Infections Caused by Multidrug-Resistant Enterobacteriaceae in Children, 2007-2015.
Article in Journal of the Pediatric Infectious Diseases Society, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 65 citations in OpenAlex.
- Non-prescription antibiotic use and its predictors among children in low- and middle-income countries: a systematic review and meta-analysis.Italian journal of pediatrics · 2024Pooled it
- Population Pharmacokinetic Modeling and Probability of Pharmacodynamic Target Attainment for Ceftazidime-Avibactam in Pediatric Patients Aged 3 Months and Older.Clinical pharmacology and therapeutics · 2022Trial
- Epidemiological trends of multidrug-resistant organisms in a tertiary-care pediatric hospital, 2017-2023.Italian journal of pediatrics · 2026Article
- Multidrug-resistantNew microbes and new infections · 2026Article
- Genomic surveillance of multidrug-resistant Escherichia coli and Klebsiella in clinical and wastewater isolates from a paediatric hospital in Lima, Peru.Access microbiology · 2026Article
- Article
- Patterns of antibiotic resistance in uropathogens isolated from pediatric patients: A multicenter study.Saudi medical journal · 2025Article
- Antimicrobial resistance in Malaysia: a cross-sectional study analysing trends and economic impacts.BMJ open · 2025Article
- Carbapenem-Resistant and Extended-Spectrum β-Lactamase-Producing Enterobacterales in Children, United States, 2016-2020.Emerging infectious diseases · 2024Article
- Zoonosis screening in Spanish immunocompromised children and their pets.Frontiers in veterinary science · 2024Article
- Variation in antibiotic resistance patterns for children and adults treated at 166 non-affiliated US facilities using EHR data.JAC-antimicrobial resistance · 2023Article
- Development and Validation of Questionnaire to Measure Parents' Knowledge, Attitude, and Practice on Self-Medication of Children with Antibiotics in Bandung, Indonesia.Infection and drug resistance · 2023Article
- Treatment and Epidemiology of Third-Generation Cephalosporin-Resistant Urinary Tract Infections.Pediatrics · 2022Article
- Risk factors for antibiotic-resistant bacteria colonisation in children with chronic complex conditions.Scientific reports · 2022Article
- Surveillance of Multidrug-Resistant Bacterial Infections in Non-Adult Patients - Zhejiang Province, China, 2014-2019.China CDC weekly · 2021Article
- Prevalence and risk factors associated with multi-drug resistant organisms (MDRO) carriage among pediatric patients at the time of admission in a tertiary care hospital of a developing country. A cross-sectional study.BMC infectious diseases · 2021Article
- Antibiotic Resistance in Pediatric Infections: Global Emerging Threats, Predicting the Near Future.Antibiotics (Basel, Switzerland) · 2021Review
- Short-term increase in the carriage of azithromycin-resistantJAC-antimicrobial resistance · 2021Article
- Challenges of Antibiotic Stewardship in the Pediatric and Neonatal Intensive Care Units.The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG · 2021Article
- A Potential Inhibitor of MCR-1: An Attempt to Enhance the Efficacy of Polymyxin Against Multidrug-Resistant Bacteria.Current microbiology · 2020Article
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundThe escalating incidence of invasive disease caused by multidrug-resistant Gram-negative enteric Enterobacteriaceae (MDR-GNE) is a global concern. Scant published studies in which the epidemiology of these infections in children is described exist; previous studies focused mainly on adults, described circumscribed populations, or lacked clinical detail. The objective of this study was to examine and describe the incidence, risk factors, and outcomes associated with MDR-GNE infection in children.
methodsIn this cohort study, we used data from 48 children's hospitals maintained by the Pediatric Health Information System. We documented the proportion of MDR-GNE diagnoses among children's hospital patients aged 0 to <18 years who were diagnosed with an Enterobacteriaceae-associated infection between January 1, 2007, and March 31, 2015, and we analyzed the association between MDR-GNE infection and hospital length of stay and death before discharge.
resultsDuring the study period, 107610 discharges included a diagnosis code for Enterobacteriaceae infection, 724 (0.7%) of which included MDR-GNE infection. The incidence of MDR-GNE, and the proportion of infections with Enterobacteriaceae organisms that were MDR-GNE increased over the study period; from 0.2% in 2007 to 1.5% by 2015 (test for trend < .001). Almost one-quarter (23%) of the infections in children hospitalized for MDR-GNE were nosocomial. Increased odds of MDR-GNE infection were associated with older age and comorbid illnesses. Lengths of stay in patients with MDR-GNE infection were increased 20% (95% confidence interval, 9.9%-30.5%; P < .001) over those without MDR-GNE infection; the increased odds for death did not reach statistical significance (1.46 [95% confidence interval, 0.98-2.18]; P = .06). Results were robust to sensitivity analyses.
conclusionsThe incidence of pediatric MDR-GNE infection increased during 2007-2015. MDR-GNE infection was associated with increased length of stay, and we found a trend toward increased risk of death. Infections with Gram-negative enteric bacilli are becoming increasingly difficult to treat; considering the global burden of these antimicrobial-resistant organisms, interventions to curtail or even reverse this trend are needed urgently.
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