ArticleThe international journal of neuropsychopharmacology2017
Telomere Length, Oxidative Stress, Inflammation and BDNF Levels in Siblings of Patients with Bipolar Disorder: Implications for Accelerated Cellular Aging.
Open access · goldAbstract read
In one paragraph
Article in The international journal of neuropsychopharmacology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed
3.3field-weighted citation impact, top 7% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed, 92 citations in OpenAlex.
- Supplementation with eicosapentaenoic acid and docosahexaenoic acid reduces high levels of circulating proinflammatory cytokines in aging adults: A randomized, controlled study.Prostaglandins, leukotrienes, and essential fatty acids · 2018Trial
- Lithium as a Potential Senostatic Agent in Central Nervous System Aging and Bipolar Disorder.Pharmaceuticals (Basel, Switzerland) · 2026Review
- Article
- Inflammation and Cognition in Bipolar Disorder: Diverging Paths of Interleukin-6 and Outcomes.International journal of molecular sciences · 2025Article
- Immune dysregulation in bipolar disorder.Journal of affective disorders · 2025Article
- The dynamic relationship of brain-derived neurotrophic factor and oxytocin: Introducing the concept of neurosocial plasticity.Neuroprotection (Chichester, England) · 2025Review
- Limited evidence of association between dysregulated immune marker levels and telomere length in severe mental disorders.Acta neuropsychiatrica · 2025Article
- Influence of subclinical hypothyroidism and brain-derived neurotropic factor on telomere length dynamics in type 1 diabetic pregnancies and their newborns.Scientific reports · 2025Article
- Psychoneuroimmunology of Mood Disorders.Methods in molecular biology (Clifton, N.J.) · 2025Review
- Putative Risk Biomarkers of Bipolar Disorder in At-risk Youth.Neuroscience bulletin · 2024Review
- Telomere Length Associations With Clinical Diagnosis, Age, and Polygenic Risk Scores for Anxiety Disorder, Depression, and Bipolar Disorder.Biological psychiatry global open science · 2023Article
- Epigenetic age deacceleration in youth at familial risk for schizophrenia and bipolar disorder.Translational psychiatry · 2023Article
- Mitochondrial DNA oxidation, methylation, and copy number alterations in major and bipolar depression.Frontiers in psychiatry · 2023Article
- Cognitive Impairment Mechanism in Patients with Bipolar Disorder.Neuropsychiatric disease and treatment · 2023Review
- Review
- Article
- Inflammatory Markers in Substance Use and Mood Disorders: A Neuroimaging Perspective.Frontiers in psychiatry · 2022Review
- Investigating the Role of Leukocyte Telomere Length in Treatment-Resistant Depression and in Response to Electroconvulsive Therapy.Journal of personalized medicine · 2021Article
- Atorvastatin modulates the expression of aging-related genes in the brain of aging induced by D-galactose in mice.Iranian journal of basic medical sciences · 2021Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors at 3 institutions in 1 country.
Mirela Paiva Vasconcelos-MorenoLaboratório de Psiquiatria Molecular, Instituto Nacional de Ciência e Tecnologia Translacional em Medicina (INCT-TM), Hospital deClínicas de Porto Alegre, Porto Alegre, RS, Brasil (Drs Vasconcelos-Moreno, Rodrigo Fries, Tietböhl Martins Quadros dos Santos, Fijtman, and Sartori, Ms Ferrari, and Drs Kapczinski, Ribeiro Rosa, Kauer-Sant'Anna); Programa de Pós Graduação em Ciências Médicas - Psiquiatria, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil (Drs Paiva Vasconcelos-Moreno and Sartori, Ms Ferrari, Drs Kapczinski, Ribeiro Rosa, and Kauer-Sant'Anna); Programa de Pós-Graduação Ciências Biológicas - Bioquímica, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil (Dr Rodrigo Fries and Ms Gubert); Laboratório de Biologia Molecular e Bioinformática, Departamento de Bioquímica, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil (Mr Kich Grun, Ms Migliorini Parisi, and Drs Theresinha Costa Rodrigues Guma and Barbé-Tuana); Mood Disorders Center, University of British Columbia, Vancouver, BC, Canada (Dr Yatham).
Gabriel Rodrigo FriesLaboratório de Psiquiatria Molecular, Instituto Nacional de Ciência e Tecnologia Translacional em Medicina (INCT-TM), Hospital deClínicas de Porto Alegre, Porto Alegre, RS, Brasil (Drs Vasconcelos-Moreno, Rodrigo Fries, Tietböhl Martins Quadros dos Santos, Fijtman, and Sartori, Ms Ferrari, and Drs Kapczinski, Ribeiro Rosa, Kauer-Sant'Anna); Programa de Pós Graduação em Ciências Médicas - Psiquiatria, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil (Drs Paiva Vasconcelos-Moreno and Sartori, Ms Ferrari, Drs Kapczinski, Ribeiro Rosa, and Kauer-Sant'Anna); Programa de Pós-Graduação Ciências Biológicas - Bioquímica, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil (Dr Rodrigo Fries and Ms Gubert); Laboratório de Biologia Molecular e Bioinformática, Departamento de Bioquímica, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil (Mr Kich Grun, Ms Migliorini Parisi, and Drs Theresinha Costa Rodrigues Guma and Barbé-Tuana); Mood Disorders Center, University of British Columbia, Vancouver, BC, Canada (Dr Yatham).
Carolina GubertLaboratório de Psiquiatria Molecular, Instituto Nacional de Ciência e Tecnologia Translacional em Medicina (INCT-TM), Hospital deClínicas de Porto Alegre, Porto Alegre, RS, Brasil (Drs Vasconcelos-Moreno, Rodrigo Fries, Tietböhl Martins Quadros dos Santos, Fijtman, and Sartori, Ms Ferrari, and Drs Kapczinski, Ribeiro Rosa, Kauer-Sant'Anna); Programa de Pós Graduação em Ciências Médicas - Psiquiatria, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil (Drs Paiva Vasconcelos-Moreno and Sartori, Ms Ferrari, Drs Kapczinski, Ribeiro Rosa, and Kauer-Sant'Anna); Programa de Pós-Graduação Ciências Biológicas - Bioquímica, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil (Dr Rodrigo Fries and Ms Gubert); Laboratório de Biologia Molecular e Bioinformática, Departamento de Bioquímica, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil (Mr Kich Grun, Ms Migliorini Parisi, and Drs Theresinha Costa Rodrigues Guma and Barbé-Tuana); Mood Disorders Center, University of British Columbia, Vancouver, BC, Canada (Dr Yatham).
Bárbara Tietböhl Martins Quadros Dos SantosLaboratório de Psiquiatria Molecular, Instituto Nacional de Ciência e Tecnologia Translacional em Medicina (INCT-TM), Hospital deClínicas de Porto Alegre, Porto Alegre, RS, Brasil (Drs Vasconcelos-Moreno, Rodrigo Fries, Tietböhl Martins Quadros dos Santos, Fijtman, and Sartori, Ms Ferrari, and Drs Kapczinski, Ribeiro Rosa, Kauer-Sant'Anna); Programa de Pós Graduação em Ciências Médicas - Psiquiatria, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil (Drs Paiva Vasconcelos-Moreno and Sartori, Ms Ferrari, Drs Kapczinski, Ribeiro Rosa, and Kauer-Sant'Anna); Programa de Pós-Graduação Ciências Biológicas - Bioquímica, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil (Dr Rodrigo Fries and Ms Gubert); Laboratório de Biologia Molecular e Bioinformática, Departamento de Bioquímica, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil (Mr Kich Grun, Ms Migliorini Parisi, and Drs Theresinha Costa Rodrigues Guma and Barbé-Tuana); Mood Disorders Center, University of British Columbia, Vancouver, BC, Canada (Dr Yatham).
Adam FijtmanLaboratório de Psiquiatria Molecular, Instituto Nacional de Ciência e Tecnologia Translacional em Medicina (INCT-TM), Hospital deClínicas de Porto Alegre, Porto Alegre, RS, Brasil (Drs Vasconcelos-Moreno, Rodrigo Fries, Tietböhl Martins Quadros dos Santos, Fijtman, and Sartori, Ms Ferrari, and Drs Kapczinski, Ribeiro Rosa, Kauer-Sant'Anna); Programa de Pós Graduação em Ciências Médicas - Psiquiatria, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil (Drs Paiva Vasconcelos-Moreno and Sartori, Ms Ferrari, Drs Kapczinski, Ribeiro Rosa, and Kauer-Sant'Anna); Programa de Pós-Graduação Ciências Biológicas - Bioquímica, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil (Dr Rodrigo Fries and Ms Gubert); Laboratório de Biologia Molecular e Bioinformática, Departamento de Bioquímica, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil (Mr Kich Grun, Ms Migliorini Parisi, and Drs Theresinha Costa Rodrigues Guma and Barbé-Tuana); Mood Disorders Center, University of British Columbia, Vancouver, BC, Canada (Dr Yatham).
Juliana SartoriLaboratório de Psiquiatria Molecular, Instituto Nacional de Ciência e Tecnologia Translacional em Medicina (INCT-TM), Hospital deClínicas de Porto Alegre, Porto Alegre, RS, Brasil (Drs Vasconcelos-Moreno, Rodrigo Fries, Tietböhl Martins Quadros dos Santos, Fijtman, and Sartori, Ms Ferrari, and Drs Kapczinski, Ribeiro Rosa, Kauer-Sant'Anna); Programa de Pós Graduação em Ciências Médicas - Psiquiatria, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil (Drs Paiva Vasconcelos-Moreno and Sartori, Ms Ferrari, Drs Kapczinski, Ribeiro Rosa, and Kauer-Sant'Anna); Programa de Pós-Graduação Ciências Biológicas - Bioquímica, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil (Dr Rodrigo Fries and Ms Gubert); Laboratório de Biologia Molecular e Bioinformática, Departamento de Bioquímica, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil (Mr Kich Grun, Ms Migliorini Parisi, and Drs Theresinha Costa Rodrigues Guma and Barbé-Tuana); Mood Disorders Center, University of British Columbia, Vancouver, BC, Canada (Dr Yatham).
Pamela FerrariLaboratório de Psiquiatria Molecular, Instituto Nacional de Ciência e Tecnologia Translacional em Medicina (INCT-TM), Hospital deClínicas de Porto Alegre, Porto Alegre, RS, Brasil (Drs Vasconcelos-Moreno, Rodrigo Fries, Tietböhl Martins Quadros dos Santos, Fijtman, and Sartori, Ms Ferrari, and Drs Kapczinski, Ribeiro Rosa, Kauer-Sant'Anna); Programa de Pós Graduação em Ciências Médicas - Psiquiatria, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil (Drs Paiva Vasconcelos-Moreno and Sartori, Ms Ferrari, Drs Kapczinski, Ribeiro Rosa, and Kauer-Sant'Anna); Programa de Pós-Graduação Ciências Biológicas - Bioquímica, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil (Dr Rodrigo Fries and Ms Gubert); Laboratório de Biologia Molecular e Bioinformática, Departamento de Bioquímica, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil (Mr Kich Grun, Ms Migliorini Parisi, and Drs Theresinha Costa Rodrigues Guma and Barbé-Tuana); Mood Disorders Center, University of British Columbia, Vancouver, BC, Canada (Dr Yatham).
Lucas Kich GrunLaboratório de Psiquiatria Molecular, Instituto Nacional de Ciência e Tecnologia Translacional em Medicina (INCT-TM), Hospital deClínicas de Porto Alegre, Porto Alegre, RS, Brasil (Drs Vasconcelos-Moreno, Rodrigo Fries, Tietböhl Martins Quadros dos Santos, Fijtman, and Sartori, Ms Ferrari, and Drs Kapczinski, Ribeiro Rosa, Kauer-Sant'Anna); Programa de Pós Graduação em Ciências Médicas - Psiquiatria, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil (Drs Paiva Vasconcelos-Moreno and Sartori, Ms Ferrari, Drs Kapczinski, Ribeiro Rosa, and Kauer-Sant'Anna); Programa de Pós-Graduação Ciências Biológicas - Bioquímica, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil (Dr Rodrigo Fries and Ms Gubert); Laboratório de Biologia Molecular e Bioinformática, Departamento de Bioquímica, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil (Mr Kich Grun, Ms Migliorini Parisi, and Drs Theresinha Costa Rodrigues Guma and Barbé-Tuana); Mood Disorders Center, University of British Columbia, Vancouver, BC, Canada (Dr Yatham).
Mariana Migliorini ParisiLaboratório de Psiquiatria Molecular, Instituto Nacional de Ciência e Tecnologia Translacional em Medicina (INCT-TM), Hospital deClínicas de Porto Alegre, Porto Alegre, RS, Brasil (Drs Vasconcelos-Moreno, Rodrigo Fries, Tietböhl Martins Quadros dos Santos, Fijtman, and Sartori, Ms Ferrari, and Drs Kapczinski, Ribeiro Rosa, Kauer-Sant'Anna); Programa de Pós Graduação em Ciências Médicas - Psiquiatria, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil (Drs Paiva Vasconcelos-Moreno and Sartori, Ms Ferrari, Drs Kapczinski, Ribeiro Rosa, and Kauer-Sant'Anna); Programa de Pós-Graduação Ciências Biológicas - Bioquímica, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil (Dr Rodrigo Fries and Ms Gubert); Laboratório de Biologia Molecular e Bioinformática, Departamento de Bioquímica, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil (Mr Kich Grun, Ms Migliorini Parisi, and Drs Theresinha Costa Rodrigues Guma and Barbé-Tuana); Mood Disorders Center, University of British Columbia, Vancouver, BC, Canada (Dr Yatham).
Fátima Theresinha Costa Rodrigues GumaLaboratório de Psiquiatria Molecular, Instituto Nacional de Ciência e Tecnologia Translacional em Medicina (INCT-TM), Hospital deClínicas de Porto Alegre, Porto Alegre, RS, Brasil (Drs Vasconcelos-Moreno, Rodrigo Fries, Tietböhl Martins Quadros dos Santos, Fijtman, and Sartori, Ms Ferrari, and Drs Kapczinski, Ribeiro Rosa, Kauer-Sant'Anna); Programa de Pós Graduação em Ciências Médicas - Psiquiatria, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil (Drs Paiva Vasconcelos-Moreno and Sartori, Ms Ferrari, Drs Kapczinski, Ribeiro Rosa, and Kauer-Sant'Anna); Programa de Pós-Graduação Ciências Biológicas - Bioquímica, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil (Dr Rodrigo Fries and Ms Gubert); Laboratório de Biologia Molecular e Bioinformática, Departamento de Bioquímica, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil (Mr Kich Grun, Ms Migliorini Parisi, and Drs Theresinha Costa Rodrigues Guma and Barbé-Tuana); Mood Disorders Center, University of British Columbia, Vancouver, BC, Canada (Dr Yatham).
Florencia Maria Barbé-TuanaLaboratório de Psiquiatria Molecular, Instituto Nacional de Ciência e Tecnologia Translacional em Medicina (INCT-TM), Hospital deClínicas de Porto Alegre, Porto Alegre, RS, Brasil (Drs Vasconcelos-Moreno, Rodrigo Fries, Tietböhl Martins Quadros dos Santos, Fijtman, and Sartori, Ms Ferrari, and Drs Kapczinski, Ribeiro Rosa, Kauer-Sant'Anna); Programa de Pós Graduação em Ciências Médicas - Psiquiatria, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil (Drs Paiva Vasconcelos-Moreno and Sartori, Ms Ferrari, Drs Kapczinski, Ribeiro Rosa, and Kauer-Sant'Anna); Programa de Pós-Graduação Ciências Biológicas - Bioquímica, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil (Dr Rodrigo Fries and Ms Gubert); Laboratório de Biologia Molecular e Bioinformática, Departamento de Bioquímica, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil (Mr Kich Grun, Ms Migliorini Parisi, and Drs Theresinha Costa Rodrigues Guma and Barbé-Tuana); Mood Disorders Center, University of British Columbia, Vancouver, BC, Canada (Dr Yatham).
Flávio KapczinskiLaboratório de Psiquiatria Molecular, Instituto Nacional de Ciência e Tecnologia Translacional em Medicina (INCT-TM), Hospital deClínicas de Porto Alegre, Porto Alegre, RS, Brasil (Drs Vasconcelos-Moreno, Rodrigo Fries, Tietböhl Martins Quadros dos Santos, Fijtman, and Sartori, Ms Ferrari, and Drs Kapczinski, Ribeiro Rosa, Kauer-Sant'Anna); Programa de Pós Graduação em Ciências Médicas - Psiquiatria, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil (Drs Paiva Vasconcelos-Moreno and Sartori, Ms Ferrari, Drs Kapczinski, Ribeiro Rosa, and Kauer-Sant'Anna); Programa de Pós-Graduação Ciências Biológicas - Bioquímica, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil (Dr Rodrigo Fries and Ms Gubert); Laboratório de Biologia Molecular e Bioinformática, Departamento de Bioquímica, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil (Mr Kich Grun, Ms Migliorini Parisi, and Drs Theresinha Costa Rodrigues Guma and Barbé-Tuana); Mood Disorders Center, University of British Columbia, Vancouver, BC, Canada (Dr Yatham).
Adriane Ribeiro RosaLaboratório de Psiquiatria Molecular, Instituto Nacional de Ciência e Tecnologia Translacional em Medicina (INCT-TM), Hospital deClínicas de Porto Alegre, Porto Alegre, RS, Brasil (Drs Vasconcelos-Moreno, Rodrigo Fries, Tietböhl Martins Quadros dos Santos, Fijtman, and Sartori, Ms Ferrari, and Drs Kapczinski, Ribeiro Rosa, Kauer-Sant'Anna); Programa de Pós Graduação em Ciências Médicas - Psiquiatria, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil (Drs Paiva Vasconcelos-Moreno and Sartori, Ms Ferrari, Drs Kapczinski, Ribeiro Rosa, and Kauer-Sant'Anna); Programa de Pós-Graduação Ciências Biológicas - Bioquímica, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil (Dr Rodrigo Fries and Ms Gubert); Laboratório de Biologia Molecular e Bioinformática, Departamento de Bioquímica, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil (Mr Kich Grun, Ms Migliorini Parisi, and Drs Theresinha Costa Rodrigues Guma and Barbé-Tuana); Mood Disorders Center, University of British Columbia, Vancouver, BC, Canada (Dr Yatham).
Lakshmi N YathamLaboratório de Psiquiatria Molecular, Instituto Nacional de Ciência e Tecnologia Translacional em Medicina (INCT-TM), Hospital deClínicas de Porto Alegre, Porto Alegre, RS, Brasil (Drs Vasconcelos-Moreno, Rodrigo Fries, Tietböhl Martins Quadros dos Santos, Fijtman, and Sartori, Ms Ferrari, and Drs Kapczinski, Ribeiro Rosa, Kauer-Sant'Anna); Programa de Pós Graduação em Ciências Médicas - Psiquiatria, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil (Drs Paiva Vasconcelos-Moreno and Sartori, Ms Ferrari, Drs Kapczinski, Ribeiro Rosa, and Kauer-Sant'Anna); Programa de Pós-Graduação Ciências Biológicas - Bioquímica, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil (Dr Rodrigo Fries and Ms Gubert); Laboratório de Biologia Molecular e Bioinformática, Departamento de Bioquímica, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil (Mr Kich Grun, Ms Migliorini Parisi, and Drs Theresinha Costa Rodrigues Guma and Barbé-Tuana); Mood Disorders Center, University of British Columbia, Vancouver, BC, Canada (Dr Yatham).
Marcia Kauer-Sant'AnnaLaboratório de Psiquiatria Molecular, Instituto Nacional de Ciência e Tecnologia Translacional em Medicina (INCT-TM), Hospital deClínicas de Porto Alegre, Porto Alegre, RS, Brasil (Drs Vasconcelos-Moreno, Rodrigo Fries, Tietböhl Martins Quadros dos Santos, Fijtman, and Sartori, Ms Ferrari, and Drs Kapczinski, Ribeiro Rosa, Kauer-Sant'Anna); Programa de Pós Graduação em Ciências Médicas - Psiquiatria, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil (Drs Paiva Vasconcelos-Moreno and Sartori, Ms Ferrari, Drs Kapczinski, Ribeiro Rosa, and Kauer-Sant'Anna); Programa de Pós-Graduação Ciências Biológicas - Bioquímica, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil (Dr Rodrigo Fries and Ms Gubert); Laboratório de Biologia Molecular e Bioinformática, Departamento de Bioquímica, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil (Mr Kich Grun, Ms Migliorini Parisi, and Drs Theresinha Costa Rodrigues Guma and Barbé-Tuana); Mood Disorders Center, University of British Columbia, Vancouver, BC, Canada (Dr Yatham).
Hospital de Clínicas de Porto Alegre · BRInstituto Nacional de Ciência e Tecnologia Translacional em MedicinaUniversidade Federal do Rio Grande do Sul · BR
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Growing evidence supports the existence of neurobiological trait abnormalities in individuals at genetic risk for bipolar disorder. The aim of this study was to examine potential differences in brain-derived neurotrophic factor, cytokines, oxidative stress, and telomere length markers between patients with bipolar disorder, their siblings, and healthy controls. Methods: Thirty-six patients with bipolar disorder type I, 39 siblings, and 44 healthy controls were assessed. Serum levels of brain-derived neurotrophic factor, interleukin-6, interleukin-10, tumor necrosis factor-α, C-C motif chemokine 11, C-C motif chemokine 24, and 3-nitrotyrosine were measured, as were the activities of glutathione peroxidase, glutathione reductase, and glutathione S-transferase. Telomere length (T/S ratio) was measured using quantitative polymerase chain reaction. Results: Telomere length was different between the 3 groups (P = .041) with both patients and siblings showing a shorter T/S ratio compared with healthy controls. Patients showed increased levels of interleukin-6 (P = .005) and interleukin-10 (P = .002) compared with controls as well as increased levels of interleukin-6 (p = 0.014) and CCL24 (P = .016) compared with their siblings. C-C motif chemokine 11 levels were increased in siblings compared with controls (P = .015), and a similar tendency was found in patients compared with controls (P = .045). Glutathione peroxidase activity was decreased in patients compared with controls (P = .006) and siblings (P = .025). No differences were found for the other markers. Conclusions: The present results suggest that unaffected siblings may present accelerated aging features. These neurobiological findings may be considered as endophenotypic traits. Further prospective studies are warranted.
Indexed as
SiblingsBiomarkersBipolar DisorderCellular SenescenceCross-Sectional StudiesFemaleGenetic Predisposition to DiseaseHumansInflammationInterview, PsychologicalMaleMiddle AgedOxidative StressTelomereBiomarkersaging.biomarkersbipolar disordersiblingstelomere
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY-NC
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.