ArticleJournal of the Pediatric Infectious Diseases Society2017
High Postdischarge Morbidity in Ugandan Children With Severe Malarial Anemia or Cerebral Malaria.
Article in Journal of the Pediatric Infectious Diseases Society, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 3 of them syntheses that pooled it.
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Who cites it
37 citing papers in PubMed, 3 syntheses or guidelines pooled it, 39 citations in OpenAlex.
- Implementation of post-discharge malaria chemoprevention (PDMC) in Benin, Kenya, Malawi, and Uganda: stakeholder engagement meeting report.Malaria journal · 2024Pooled it
- Post-discharge morbidity and mortality in children admitted with severe anaemia and other health conditions in malaria-endemic settings in Africa: a systematic review and meta-analysis.The Lancet. Child & adolescent health · 2022Pooled it
- Pooled it
- Malaria Chemoprevention in the Postdischarge Management of Severe Anemia.The New England journal of medicine · 2020Trial
- Delayed iron improves iron status without altering malaria risk in severe malarial anemia.The American journal of clinical nutrition · 2020Trial
- Adherence to the Revised National Malaria Case Management Guidelines Among Healthcare Workers at Mzimba District Hospital in Northern Malawi.Public health challenges · 2026Article
- Article
- Severe malarial anaemia in childhood is associated with decreased long-term household wealth.BMC public health · 2025Article
- The 24, 2 hours initiative: a game changer in malaria mortality reduction.Malaria journal · 2025Review
- Diverging pathways: exploring the interplay between hospital readmission and postdischarge mortality in paediatric sepsis in low-income settings.BMJ global health · 2025Observational
- Malaria associated pathogenesis of chronic kidney disease (MAP-CKD): a prospective study of children hospitalized with severe malaria.BMC nephrology · 2025Article
- Elevated Levels of PDGF-BB and VEGF Are Associated With a Decreased Risk of Readmission or Death in Children With Severe Malarial Anemia.The Journal of infectious diseases · 2025Article
- Elevated uric acid levels, mortality and cognitive impairment in children with severe malaria.Nature medicine · 2025Article
- Severe malaria readmissions in Northern Uganda: a cross-sectional study.Malaria journal · 2025Article
- The Association Between Malaria Parasite Geometrical Mean and Clinical Spectrum of Severe Disease in a High-Transmission Setting in Eastern Uganda: A Cross-Sectional Study.Journal of parasitology research · 2025Article
- Severe falciparum malaria in young children is associated with an increased risk of post-discharge hospitalization: a prospective cohort study.Malaria journal · 2024Article
- Determinants of Anemia in Schoolchildren in the Highland Bolivia.Microorganisms · 2024Article
- Severe falciparum malaria in young children is associated with an increased risk of post-discharge readmission or death: A prospective cohort study.Research square · 2024Article
- Prevalence and factors associated with cerebral malaria among children aged 6 to 59 months with severe malaria in Western Uganda: a hospital-based cross-sectional study.BMC pediatrics · 2024Article
- Inpatient and postdischarge mortality among children with anaemia and malaria parasitaemia in Kenya: a cohort study.BMJ global health · 2024Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
Abstract
backgroundCerebral malaria (CM) and severe malarial anemia (SMA) account for a substantial proportion of malaria-related deaths in sub-Saharan Africa. However, postdischarge morbidity in children with CM or SMA has not been well established.
methodsChildren 18 months to 12 years of age, enrolled on admission to Mulago National Referral Hospital in Kampala, Uganda (CM, n = 162; SMA, n = 138), and healthy children recruited from the community (CC) (n = 133) were followed up for 6 months. The incidences of hospitalizations and outpatient clinic visits for illness during the follow-up period were compared between children with CM or SMA and the CC.
resultsAfter adjustment for age, sex, and nutritional status, children with SMA had a higher incidence rate ratio (IRR) than CC for hospitalization (95% confidence interval [CI], 20.81 [2.48-174.68]), hospitalization with malaria (17.29 [95% CI, 2.02-148.35]), and clinic visits for any illness (95% CI, 2.35 [1.22-4.51]). Adjusted IRRs for children with CM were also increased for all measures compared with those for CC, but they achieved statistical significance only for clinic visits for any illness (2.24 [95% CI, 1.20-4.15]). In both groups, the primary reason for the clinic visits and hospitalizations was malaria.
conclusionsIn the 6 months after initial hospitalization, children with SMA have an increased risk of repeated hospitalization, and children with CM or SMA have an increased risk of outpatient illness. Malaria is the main cause of inpatient and outpatient morbidity. Malaria prophylaxis has the potential to decrease postdischarge morbidity rates in children with SMA or CM.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.