Evidence map›Paper›PMID 28339574›Full record

ArticleJournal of the Pediatric Infectious Diseases Society2017

Arm Paralysis After Routine Childhood Vaccinations: Application of Advanced Molecular Methods to the Causality Assessment of an Adverse Event After Immunization.

Jana Shaw, Neal A Halsey, Adriana Weinberg, D Scott Schmid, Kirsten St George, William C Weldon, Michael Jordan, Patrick W Bryant, Philip S LaRussa, Deborah Y Bradshaw and 2 more

Open access · bronzeAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the Pediatric Infectious Diseases Society, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 9 institutions in 1 country.

Jana ShawDepartment of Pediatrics, Division of Infectious Diseases, State University of New York Upstate Medical University, Golisano Children's Hospital, Syracuse.
Neal A HalseyInstitute for Vaccine Safety, Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland.
Adriana WeinbergDepartments of Pediatrics, Medicine and Pathology, Director, Molecular and Virology Clinical Laboratories, University of Colorado Denver, Aurora.
D Scott SchmidNational Center for Immunizations and Respiratory Diseases, Division of Viral Diseases, Atlanta, Georgia.
Kirsten St GeorgeLaboratory of Viral Diseases, Wadsworth Center, New York State Department of Health, Clinical Professor, Department of Biomedical Sciences, University at Albany, SUNY.
William C WeldonDivision of Viral Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia.
Michael JordanPediatrics, Divisions of Immunobiology, and Bone Marrow Transplantation and Immune Deficiency Cincinnati Children's Hospital/University of Cincinnati, Ohio.
Patrick W BryantLaboratory of Viral Diseases, Wadsworth Center, New York State Department of Health, Albany.
Philip S LaRussaDepartment of Pediatrics, Division of Pediatric Infectious Diseases, Columbia University, New York, New York.
Deborah Y BradshawDepartment of Neurology, Upstate Medical University, New York, New York.
Theresa HarringtonCenters for Disease Control and Prevention, National Center for Emerging, Zoonotic, and Infectious Diseases, Division of Healthcare Quality Promotion, Immunization Safety Office, Clinical Immunization Safety Assessment Project, Atlanta, Georgia.
Anne GershonColumbia University College of Physicians and Surgeons, New York, New York.
Centers for Disease Control and Prevention · USColumbia University · USNew York State Department of Health · USGolisano Children's Hospital · USJohns Hopkins University · USNational Center for Immunization and Respiratory Diseases · USSUNY Upstate Medical University · USUniversity of Cincinnati · USUniversity of Colorado Denver · US

Funding

VZV in the enteric nervous system: pathogenesis and consequencesR01DK093094 · NIDDK · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MICHAEL D GERSHON, Anne A. Gershon · 2011 to 2026
$5.9M
NIDDK NIH HHS R01 DK093094
6 · The paper itself

Abstract

Post-licensure surveillance for adverse events following immunizations (AEFI) can identify rare complications of vaccinations and rigorous vaccine adverse event causality assessments can help to identify possible causal relationships. We report the development of arm paralysis after varicella vaccination in a 1-year-old child. Paralysis was initially presumed to be due to vOka because of the temporal relationship between vaccination and onset of arm weakness; however, molecular studies identified wild-type varicella zoster virus VZV (WT-VZV) in the CSF, leading the authors to conclude that WT-VZV was the probable cause. This case illustrates the complexity of assessing AEFI causality, and the importance of careful and complete evaluations when determining the most likely cause of an AEFI.

Indexed as

ArmChildHumansInfantMaleParalysisProduct Surveillance, PostmarketingVaccinationadverse event after vaccinationchildparalysisvaccinevaricella-zoster virus

Identifiers

PMID28339574
PMCPMC6251534
OpenAlexW2750657143

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.