ArticlePloS one2017
A preliminary study of skin ultrasound in diffuse cutaneous systemic sclerosis: Does skin echogenicity matter?
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.
- High-resolution ultrasound imaging of skin involvement in systemic sclerosis: a systematic review.Rheumatology international · 2021Pooled it
- Quantitative Analysis of the Human Face Skin Thickness-A High-Frequency Ultrasound Study.Journal of clinical medicine · 2025Article
- Dual optical elastography detectsJournal of biomedical optics · 2024Article
- Skin Ultrasound Assessment of Patients with Systemic Scleroderma-An Observational Study.Journal of personalized medicine · 2024Article
- Shear wave elastography-based skin assessment system for systemic sclerosis: a supplement or alternative to conventional ultrasound?Quantitative imaging in medicine and surgery · 2023Article
- Elastography as a possible useful method of assessment of skin involvement in systemic sclerosis.Postepy dermatologii i alergologii · 2022Article
- Skin involvement in early diffuse cutaneous systemic sclerosis: an unmet clinical need.Nature reviews. Rheumatology · 2022Review
- Examination of the Validity of Skin Ultrasound to Quantitate Skin Involvement for Multicenter Clinical Trials in Patients with Systemic Sclerosis (SSc): A Systematic Literature Review (SLR).ACR open rheumatology · 2022Article
- The role of ultrasound in systemic sclerosis: On the cutting edge to foster clinical and research advancement.Journal of scleroderma and related disorders · 2021Review
- Assessment of Sclerodermoid Chronic Graft-versus-host Disease with Colour Doppler Ultrasound.Acta dermato-venereologica · 2021Article
- The Updated Role of Ultrasound in Assessing Dermatological Manifestations in Systemic Sclerosis.Open access rheumatology : research and reviews · 2021Review
- How to perform high ultrasound examination of skin involvement among patients with systemic sclerosis - proposition of a unified protocol.Reumatologia · 2021Article
- Ultrasound assessment of skin thickness and stiffness: the correlation with histology and clinical score in systemic sclerosis.Arthritis research & therapy · 2020Article
- How much of skin improvement over time in systemic sclerosis is due to normal ageing? A prospective study with shear-wave elastography.Arthritis research & therapy · 2020Article
- Translational optical coherence elastography for assessment of systemic sclerosis.Journal of biophotonics · 2019Article
- High-frequency ultrasound of the skin in systemic sclerosis: an exploratory study to examine correlation with disease activity and to define the minimally detectable difference.Arthritis research & therapy · 2018Article
Corrections and comments
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Authors and funding
11 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo evaluate the usefulness of skin ultrasound and acoustic radiation force impulse (ARFI) quantification in diffuse cutaneous systemic sclerosis (dcSSc). PATIENTS AND
methods28 patients with dcSSc, and 15 age gender matched normal controls were recruited. Skin echogenicity, thickness, and ARFI quantification were measured by ultrasound at 17 sites corresponding to the modified Rodnan skin score (mRSS) in each participant. Compared with controls, skin echogenicity of dcSSc patients was classified into isoechoic, hypoechoic, and hyperechoic. The skin thickness, ARFI quantification and mRSS were compared between isoechoic, hypoechoic, hyperechoic and controls.
resultsIn patients with dcSSc, the skin thickness increased as the echogenicity changed on the order of isoechoic, hypoechoic and hyperechoic. ARFI quantification was significantly higher in hyperechoic than isoechoic (p<0.001). The mRSS were significantly higher in hyperechoic and/or hypoechoic than isoechoic. For isoechoic patients and healthy controls, the skin echogenicity or thickness was no significant different, however, the ARFI quantification was significantly higher in isoechoic than controls.
conclusionSkin ultrasound is feasible for assessing the skin involvement in dcSSc. Skin echogenicity correlates with skin thickness, stiffness, and mRSS. ARFI quantification may be more sensitive to detect skin changes, compared with skin echogenicity and thickness.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.