ArticleActa oncologica (Stockholm, Sweden)2017
Descriptive characteristics of colon and rectal cancer recurrence in a Danish population-based study.
Article in Acta oncologica (Stockholm, Sweden), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 21 citations in OpenAlex.
- Multilevel analysis of social determinants of advanced stage colorectal cancer diagnosis.Scientific reports · 2024Observational
- Breast and colorectal cancer recurrence-free survival estimates in the US: Modeling versus active data collection.Cancer epidemiology · 2023Article
- Identifying Recurrences Among Non-Metastatic Colorectal Cancer Patients Using National Health Data Registries: Validation and Optimization of a Registry-Based Algorithm in a Modern Danish Cohort.Clinical epidemiology · 2023Article
- Determining the Risk Factors Affecting on Death Due to Colorectal Cancer Progression: Survival Analysis in the Presence of Competing Risks.Journal of gastrointestinal cancer · 2022Article
- Disease recurrence after colorectal cancer surgery in the modern era: a population-based study.International journal of colorectal disease · 2021Article
- Differential short-term outcomes of laparoscopic resection in colon and rectal cancer patients aged 80 and older: an analysis of Nationwide Inpatient Sample.Surgical endoscopy · 2021Article
- Factors related to mortality due to progression of disease in patients with colon cancer in the presence of competing risks: a retrospective cohort study in the west of Iran.Gastroenterology and hepatology from bed to bench · 2021Article
- Specific causes of recurrence after surgery and mortality in patients with colorectal cancer: A competing risks survival analysis.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2021Article
- Application of the Adaptive Validation Substudy Design to Colorectal Cancer Recurrence.Clinical epidemiology · 2020Article
- Adjuvant Pressurized IntraPeritoneal Aerosol Chemotherapy (PIPAC) in resected high-risk colon cancer patients - study protocol for the PIPAC-OPC3 Trial. A prospective, controlled phase 2 Study.Pleura and peritoneum · 2018Article
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Authors and funding
8 authors at 5 institutions in 2 countries.
Funding
Abstract
backgroundRecurrence is a common outcome among patients that have undergone an intended curative resection for colorectal cancer. However, data on factors that influence colorectal cancer recurrence are sparse. We report descriptive characteristics of both colon and rectal cancer recurrence in an unselected population. MATERIAL AND
methodsWe identified 21,152 patients with colorectal cancer diagnosed between May 2001 and December 2011 and registered with the Danish Colorectal Cancer Group. Recurrences were identified in 3198 colon and 1838 rectal cancer patients during follow-up. We calculated the frequency, proportion, and incidence rates of colon and rectal cancer recurrence within descriptive categories, and the cumulative five- and ten-year incidences of recurrence, treating death as a competing risk. We used a Cox proportional hazard model to calculate hazard ratios (HR) and 95% confidence intervals (CI).
resultsRecurrence risk was highest in the first three years of follow-up. Patients <55 years old at initial diagnosis (incidence rate for colon: 7.2 per 100 person-years; 95% CI: 6.5-7.9; rectum: 8.1 per 100 person-years; 95% CI: 7.2-9.0) and patients diagnosed with stage III cancer (colon HR: 5.70; 95% CI: 4.61-7.06; rectal HR: 7.02; 95% CI: 5.58-8.82) had increased risk of recurrence. Patients diagnosed with stage III cancer from 2009 to 2011 had a lower incidence of recurrence than those diagnosed with stage III cancer in the years before. Cumulative incidences of colon and rectal cancer recurrence were similar for both cancer types among each descriptive category.
conclusionsIn this population, increases in colorectal cancer recurrence risk were associated with younger age and increasing stage at diagnosis. Cumulative incidence of recurrence did not differ by cancer type. Descriptive characteristics of colon and rectal cancer recurrence may help to inform patient-physician decision-making, and could be used to determine adjuvant therapies or tailor surveillance strategies so that recurrence may be identified early, particularly within the first 3 years of follow-up.
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