ReviewMolecular medicine reports2017
Health risk assessment of environmental selenium: Emerging evidence and challenges (Review).
Review in Molecular medicine reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
52 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Selenium exposure and the risk of type 2 diabetes: a systematic review and meta-analysis.European journal of epidemiology · 2018Pooled it
- Selenium for preventing cancer.The Cochrane database of systematic reviews · 2018Pooled it
- Geospatial Association between Keshan Disease and Selenoprotein P in Heilongjiang Province: A Bivariate Spatial Autocorrelation Analysis.Biological trace element research · 2026Article
- Selenium deficiency-induced cardiomyopathy: a case report.European heart journal. Case reports · 2026Article
- Nanotechnology-driven biofortification of Fe, Zn, and Se in edible plants.Journal of nanobiotechnology · 2025Review
- Unveiling the Role of Selenium in Child Development: Impacts on Growth, Neurodevelopment and Immunity.Journal of clinical medicine · 2025Review
- Disentangling the role of selenium in antagonizing the toxicity of arsenic and cadmium.Archives of toxicology · 2025Review
- Evidence of eared doves consumption and the potential toxic exposure during the Regional Development period in Quito-Ecuador.Scientific reports · 2025Article
- Prenatal environmental tobacco smoke exposure: a predictor of blood selenium levels in children.Frontiers in public health · 2025Article
- Uncovering exposome-related diseases through the pathologic metallome: a novel approach for clinical populations.Frontiers in toxicology · 2025Article
- Impact of selenium and selenoproteins on idiopathic male infertility: a comprehensive review.Frontiers in nutrition · 2025Review
- Observational
- A U-shaped association between selenium intake and cancer risk.Scientific reports · 2024Article
- Article
- Using neutron activation to assess heavy metal pollution in water and sediment along Savannah River.Environmental analysis, health and toxicology · 2024Article
- Hg and Se in Muscle and Liver of Blue Shark (Prionace glauca) from the Entrance of the Gulf of California: An Insight to the Potential Risk to Human Health.Archives of environmental contamination and toxicology · 2024Article
- Optimizing the quality of horticultural crop: insights into pre-harvest practices in controlled environment agriculture.Frontiers in plant science · 2024Review
- Selenium metabolism heterogeneity in pan-cancer: insights from bulk and single-cell RNA sequencing.Journal of cancer research and clinical oncology · 2023Article
- First Generation of Antioxidant Precursors for Bioisosteric Se-NSAIDs: Design, Synthesis, and In Vitro and In Vivo Anticancer Evaluation.Antioxidants (Basel, Switzerland) · 2023Article
- Effect of Sodium selenite administration on the process of tendon healing in Wistar male rats.Experimental and therapeutic medicine · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
New data have been accumulated in the scientific literature in recent years which allow a more adequate risk assessment of selenium with reference to human health. This new evidence comes from environmental studies, carried out in populations characterized by abnormally high or low selenium intakes, and from high-quality and large randomized controlled trials with selenium recently carried out in the US and in other countries. These trials have consistently shown no beneficial effect on cancer and cardiovascular risk, and have yielded indications of unexpected toxic effects of selenium exposure. Overall, these studies indicate that the minimal amount of environmental selenium which is source of risk to human health is much lower than anticipated on the basis of older studies, since toxic effects were shown at levels of intake as low as around 260 µg/day for organic selenium and around 16 µg/day for inorganic selenium. Conversely, populations with average selenium intake of less than 13-19 µg/day appear to be at risk of a severe cardiomyopathy, Keshan disease. Overall, there is the need to reconsider the selenium standards for dietary intake, drinking water, outdoor and indoor air levels, taking into account the recently discovered adverse health effects of low-dose selenium overexposure, and carefully assessing the significance of selenium-induced proteomic changes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.