ArticleGenome biology and evolution2017
Phylogenetics of Lophotrochozoan bHLH Genes and the Evolution of Lineage-Specific Gene Duplicates.
Article in Genome biology and evolution, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed, 28 citations in OpenAlex.
- Functional analysis of conserved C. elegans bHLH family members uncovers lifespan control by a peptidergic hub neuron.PLoS biology · 2025Article
- Functional analysis of conservedbioRxiv : the preprint server for biology · 2024Article
- Regeneration in the Segmented AnnelidGenes · 2021Review
- Transcription Factors in the FungusJournal of fungi (Basel, Switzerland) · 2021Article
- Comparative and evolutionary analyses reveal conservation and divergence of the notch pathway in lophotrochozoa.Scientific reports · 2021Article
- Evidence from oyster suggests an ancient role for Pdx in regulating insulin gene expression in animals.Nature communications · 2021Article
- A compendium of DNA-binding specificities of transcription factors in Pseudomonas syringae.Nature communications · 2020Article
- The development of early pioneer neurons in the annelid Malacoceros fuliginosus.BMC evolutionary biology · 2020Article
- Phylogenetic analysis of achaete-scute complex genes in metazoans.Molecular genetics and genomics : MGG · 2020Article
- SOHLHs Might Be Gametogenesis-Specific bHLH Transcriptional Regulation Factors inFrontiers in physiology · 2019Article
- Helix-loop-helix proteins and the advent of cellular diversity: 30 years of discovery.Genes & development · 2019Review
- Sequences of Circadian Clock Proteins in the Nudibranch Molluscs Hermissenda crassicornis, Melibe leonina, and Tritonia diomedea.The Biological bulletin · 2018Article
- Investigation into the cellular origins of posterior regeneration in the annelidRegeneration (Oxford, England) · 2018Article
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The gain and loss of genes encoding transcription factors is of importance to understanding the evolution of gene regulatory complexity. The basic helix-loop-helix (bHLH) genes encode a large superfamily of transcription factors. We systematically classify the bHLH genes from five mollusc, two annelid and one brachiopod genomes, tracing the pattern of bHLH gene evolution across these poorly studied Phyla. In total, 56-88 bHLH genes were identified in each genome, with most identifiable as members of previously described bilaterian families, or of new families we define. Of such families only one, Mesp, appears lost by all these species. Additional duplications have also played a role in the evolution of the bHLH gene repertoire, with many new lophotrochozoan-, mollusc-, bivalve-, or gastropod-specific genes defined. Using a combination of transcriptome mining, RT-PCR, and in situ hybridization we compared the expression of several of these novel genes in tissues and embryos of the molluscs Crassostrea gigas and Patella vulgata, finding both conserved expression and evidence for neofunctionalization. We also map the positions of the genes across these genomes, identifying numerous gene linkages. Some reflect recent paralog divergence by tandem duplication, others are remnants of ancient tandem duplications dating to the lophotrochozoan or bilaterian common ancestors. These data are built into a model of the evolution of bHLH genes in molluscs, showing formidable evolutionary stasis at the family level but considerable within-family diversification by tandem gene duplication.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.