ArticleGenome biology and evolution2017
Evolutionary Dynamics of Pathoadaptation Revealed by Three Independent Acquisitions of the VirB/D4 Type IV Secretion System in Bartonella.
Article in Genome biology and evolution, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 53 citations in OpenAlex.
- MtvS1 and MtvS2 Interact with RNA polymerase to regulate the Francisella type V-A CRISPR-Cas system.Nature communications · 2026Article
- Comparison of transcriptomic profiles between intracellular and extracellular Bartonella henselae.Communications biology · 2025Article
- The putative type 4 secretion system effector BspD is involved in maintaining envelope integrity of the pathogenmSphere · 2024Article
- Anchorage of bacterial effector at plasma membrane via selective phosphatidic acid binding to modulate host cell signaling.PLoS pathogens · 2024Article
- Molecular pathogen screening of louse flies (Diptera: Hippoboscidae) from domestic and wild ruminants in Austria.Parasites & vectors · 2023Article
- Advancements in understanding the molecular and immune mechanisms ofFrontiers in microbiology · 2023Review
- Identification of theProceedings of the National Academy of Sciences of the United States of America · 2022Article
- Adaptive immune defense prevents Bartonella persistence upon trans-placental transmission.PLoS pathogens · 2022Article
- Article
- Evolutionary Diversification of Host-TargetedMicroorganisms · 2021Article
- Type VI Secretion System and Its Effectors PdpC, PdpD, and OpiA Contribute toInfection and immunity · 2021Article
- Zoonotic Bartonella species in Eurasian wolves and other free-ranging wild mammals from Italy.Zoonoses and public health · 2021Article
- Bats are key hosts in the radiation of mammal-associated Bartonella bacteria.Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases · 2021Article
- Structural basis for selective AMPylation of Rac-subfamily GTPases byProceedings of the National Academy of Sciences of the United States of America · 2021Article
- Bartonella type IV secretion effector BepC induces stress fiber formation through activation of GEF-H1.PLoS pathogens · 2021Article
- Bartonella effector protein C mediates actin stress fiber formation via recruitment of GEF-H1 to the plasma membrane.PLoS pathogens · 2021Article
- The Impact ofFrontiers in microbiology · 2021Review
- Longitudinal Study of Bacterial Infectious Agents in a Community of Small Mammals in New Mexico.Vector borne and zoonotic diseases (Larchmont, N.Y.) · 2020Article
- Gene Transfer Agents in Symbiotic Microbes.Results and problems in cell differentiation · 2020Review
- Bartonella gene transfer agent: Evolution, function, and proposed role in host adaptation.Cellular microbiology · 2019Review
Corrections and comments
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Authors and funding
11 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The α-proteobacterial genus Bartonella comprises a group of ubiquitous mammalian pathogens that are studied as a model for the evolution of bacterial pathogenesis. Vast abundance of two particular phylogenetic lineages of Bartonella had been linked to enhanced host adaptability enabled by lineage-specific acquisition of a VirB/D4 type IV secretion system (T4SS) and parallel evolution of complex effector repertoires. However, the limited availability of genome sequences from one of those lineages as well as other, remote branches of Bartonella has so far hampered comprehensive understanding of how the VirB/D4 T4SS and its effectors called Beps have shaped Bartonella evolution. Here, we report the discovery of a third repertoire of Beps associated with the VirB/D4 T4SS of B. ancashensis, a novel human pathogen that lacks any signs of host adaptability and is only distantly related to the two species-rich lineages encoding a VirB/D4 T4SS. Furthermore, sequencing of ten new Bartonella isolates from under-sampled lineages enabled combined in silico analyses and wet lab experiments that suggest several parallel layers of functional diversification during evolution of the three Bep repertoires from a single ancestral effector. Our analyses show that the Beps of B. ancashensis share many features with the two other repertoires, but may represent a more ancestral state that has not yet unleashed the adaptive potential of such an effector set. We anticipate that the effectors of B. ancashensis will enable future studies to dissect the evolutionary history of Bartonella effectors and help unraveling the evolutionary forces underlying bacterial host adaptation.
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