SynthesisSchizophrenia bulletin2017
Genetic Overlap Between Schizophrenia and Developmental Psychopathology: Longitudinal and Multivariate Polygenic Risk Prediction of Common Psychiatric Traits During Development.
Synthesis in Schizophrenia bulletin, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
51 citing papers in PubMed, 3 syntheses or guidelines pooled it, 82 citations in OpenAlex.
- Genetics, epigenetics, and neurobiology of childhood-onset depression: an umbrella review.Molecular psychiatry · 2024Pooled it
- Genome-wide Association Meta-analysis of Childhood and Adolescent Internalizing Symptoms.Journal of the American Academy of Child and Adolescent Psychiatry · 2022Pooled it
- Genetic Associations Between Childhood Psychopathology and Adult Depression and Associated Traits in 42 998 Individuals: A Meta-analysis.JAMA psychiatry · 2020Pooled it
- The reporting and handling of missing data in genetic epidemiological studies of mental health in childhood and adolescence: A systematic review.JCPP advances · 2026Article
- Adolescents at the crossroads: genetic associations between psychotic symptoms and antisocial traits.European child & adolescent psychiatry · 2026Article
- Polygenic scores in psychiatric research and clinical practice.Medizinische Genetik : Mitteilungsblatt des Berufsverbandes Medizinische Genetik e.V · 2026Article
- Exploring genetic confounding of the associations between screen time and depressive symptoms in adolescence and early adulthood.International journal of epidemiology · 2026Article
- Genetic sensitivity to the environment moderates the impact of positive and negative childhood experiences on psychological adjustment "for good and for bad".European psychiatry : the journal of the Association of European Psychiatrists · 2026Article
- Independent versus joint effects of polygenic or family-based schizophrenia risk in diverse ancestry youth in the ABCD study.Psychological medicine · 2025Article
- Genetic Susceptibility to the Environment Moderates the Impact of Childhood Experiences on Psychotic, Depressive, and Anxiety Dimensions.Schizophrenia bulletin · 2025Article
- Psychiatric symptoms at age 8 as predictors of specialized health service use for psychiatric disorders in late adolescence and early adulthood: findings from the Finnish Nationwide 1981 Birth Cohort Study.Frontiers in psychiatry · 2025Article
- Attention-mediated genetic influences on psychotic symptomatology in adolescence.Nature. Mental health · 2024Article
- Genetic Architectures of Adolescent Depression Trajectories in 2 Longitudinal Population Cohorts.JAMA psychiatry · 2024Article
- Examining the shared etiology of psychopathology with genome-wide association studies.Physiological reviews · 2023Review
- Polygenic risk associations with developmental and mental health outcomes in childhood and adolescence: A systematic review.medRxiv : the preprint server for health sciences · 2023Article
- A genetically informed Registered Report on adverse childhood experiences and mental health.Nature human behaviour · 2023Article
- Unique prediction of developmental psychopathology from genetic and familial risk.Journal of child psychology and psychiatry, and allied disciplines · 2022Article
- Research Review: A guide to computing and implementing polygenic scores in developmental research.Journal of child psychology and psychiatry, and allied disciplines · 2022Review
- Polygenic scores for schizophrenia and major depression are associated with psychosocial risk factors in children: evidence of gene-environment correlation.Journal of child psychology and psychiatry, and allied disciplines · 2022Article
- Early manifestations of genetic risk for neurodevelopmental disorders.Journal of child psychology and psychiatry, and allied disciplines · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 4 institutions in 2 countries.
Funding
Abstract
Background: Several nonpsychotic psychiatric disorders in childhood and adolescence can precede the onset of schizophrenia, but the etiology of this relationship remains unclear. We investigated to what extent the association between schizophrenia and psychiatric disorders in childhood is explained by correlated genetic risk factors. Methods: Polygenic risk scores (PRS), reflecting an individual's genetic risk for schizophrenia, were constructed for 2588 children from the Netherlands Twin Register (NTR) and 6127 from the Avon Longitudinal Study of Parents And Children (ALSPAC). The associations between schizophrenia PRS and measures of anxiety, depression, attention deficit hyperactivity disorder (ADHD), and oppositional defiant disorder/conduct disorder (ODD/CD) were estimated at age 7, 10, 12/13, and 15 years in the 2 cohorts. Results were then meta-analyzed, and a meta-regression analysis was performed to test differences in effects sizes over, age and disorders. Results: Schizophrenia PRS were associated with childhood and adolescent psychopathology. Meta-regression analysis showed differences in the associations over disorders, with the strongest association with childhood and adolescent depression and a weaker association for ODD/CD at age 7. The associations increased with age and this increase was steepest for ADHD and ODD/CD. Genetic correlations varied between 0.10 and 0.25. Conclusion: By optimally using longitudinal data across diagnoses in a multivariate meta-analysis this study sheds light on the development of childhood disorders into severe adult psychiatric disorders. The results are consistent with a common genetic etiology of schizophrenia and developmental psychopathology as well as with a stronger shared genetic etiology between schizophrenia and adolescent onset psychopathology.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.