ArticleDNA research : an international journal for rapid publication of reports on genes and genomes2017
Integrated miRNA and mRNA expression profiling reveals the response regulators of a susceptible tomato cultivar to early blight disease.
Article in DNA research : an international journal for rapid publication of reports on genes and genomes, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
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Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it, 51 citations in OpenAlex.
- Unraveling the genetic basis of quantitative resistance to diseases in tomato: a meta-QTL analysis and mining of transcript profiles.Plant cell reports · 2024Pooled it
- Tracking Oxidative Bursts in Tomato-Pathogen Interactions.Methods in molecular biology (Clifton, N.J.) · 2026Article
- The activity of soil microbial taxa in the rhizosphere predicts the success of root colonization.mSystems · 2025Article
- Sulfate Deficiency-Responsive MicroRNAs in Tomato Uncover an Expanded and Functionally Integrated Regulatory Network.International journal of molecular sciences · 2025Article
- Tomato miR398 knockout disrupts ROS dynamics during stress conferring heat tolerance but hypersusceptibility to necrotroph infection.Plant molecular biology · 2025Article
- Integration of mRNA and miRNA analysis reveals the molecular mechanisms of sugar beet (Beta vulgaris L.) response to salt stress.Scientific reports · 2023Article
- Global expression patterns ofFrontiers in plant science · 2023Article
- Leaf rust responsive miRNA and their target genes in wheat.Functional & integrative genomics · 2022Article
- Heightened miR6024-NLR interactions facilitate necrotrophic pathogenesis in tomato.Plant molecular biology · 2022Article
- Article
- Genome-wide characterization of theFrontiers in genetics · 2022Article
- Review: Holistic pest management against early blight disease towards sustainable agriculture.Pest management science · 2021Review
- fIdentification of B. napus small RNAs responsive to infection by a necrotrophic pathogen.BMC plant biology · 2021Article
- High throughput sequencing unravels tomato-pathogen interactions towards a sustainable plant breeding.Horticulture research · 2021Review
- Integrated Analysis of microRNA and mRNA Transcriptome Reveals the Molecular Mechanism ofFrontiers in microbiology · 2021Article
- Integrated mRNA and microRNA transcriptome analyses provide insights into paclobutrazol inhibition of lateral branching in herbaceous peony.3 Biotech · 2020Article
- Intact salicylic acid signalling is required for potato defence against the necrotrophic fungus Alternaria solani.Plant molecular biology · 2020Article
- Differential expression of microRNAs in tomato leaves treated with different light qualities.BMC genomics · 2020Article
- Article
- Characterization and discovery of miRNA and miRNA targets from apomictic and sexual genotypes of Eragrostis curvula.BMC genomics · 2019Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Early blight, caused by the fungus Alternaria solani, is a devastating foliar disease of tomatoes, causes massive yield loss each year worldwide. Molecular basis of the compatible host-pathogen interaction was elusive. We adopted next generation sequencing approach to decipher miRNAs and mRNAs that are differentially expressed during Alternaria-stress in tomato. Some of the interesting findings were also validated by alternative techniques. Our analysis revealed 181 known-miRNAs, belonging to 121 miRNA families, of which 67 miRNAs showed at least 2-fold change in expression level with the majority being downregulated. Concomitantly, 5,450 mRNAs were significantly regulated in the same diseased tissues. Differentially expressed genes were most significantly associated with response to stimulus process, photosynthesis, biosynthesis of secondary metabolites, plant-pathogen interaction and plant hormone signal transduction pathways. GO term enrichment-based categorization of gene-functions further supported this observation, as terms related to pathogen perception, disease signal transduction, cellular metabolic processes including oxidoreductase and kinase activity were over represented. In addition, we have discovered 102 miRNA-mRNA pairs which were regulated antagonistically, and careful study of the targeted mRNAs depicted that multiple transcription factors, nucleotide-binding site leucine-rich repeats, receptor-like proteins and enzymes related to cellular ROS management were profoundly affected. These studies have identified key regulators of Alternaria-stress response in tomato and the subset of genes that are likely to be post-transcriptionally silenced during the infection.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.