ArticleSocial cognitive and affective neuroscience2017
Violent offenders respond to provocations with high amygdala and striatal reactivity.
Article in Social cognitive and affective neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 4 of them syntheses that pooled it.
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Who cites it
34 citing papers in PubMed, 4 syntheses or guidelines pooled it, 91 citations in OpenAlex.
- The analysis of the prefrontal cortex and its facilitator role of violence: conclusions of a systematic review and meta-analysis based on neuroimaging results.Brain imaging and behavior · 2026Pooled it
- Using physiological biomarkers in forensic psychiatry: a scoping review.Frontiers in psychiatry · 2025Pooled it
- Psychopathy and medial frontal cortex: A systematic review reveals predominantly null relationships.Neuroscience and biobehavioral reviews · 2024Pooled it
- Neural correlates of aggression in personality disorders from the perspective of DSM-5 maladaptive traits: a systematic review.Translational psychiatry · 2023Pooled it
- Oxytocin effects on amygdala reactivity to angry faces in males and females with antisocial personality disorder.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023Trial
- BDNF and IL-33 Dynamics in an Ultrasound Stress Model of Fibromyalgia-like Phenotypes.International journal of molecular sciences · 2026Article
- Validating Temporal Eye Tracking Metrics as Orthogonal Biomarkers for Aggressive Traits: A Mixed-Effects Analysis.Journal of eye movement research · 2026Article
- Vasopressin 1a Receptor Antagonists for Pathological Aggression in Neurodegenerative and Other CNS Diseases.Biomedicines · 2026Review
- Using Machine Learning to Determine a Functional Classifier of Retaliation and Its Association With Aggression.JAACAP open · 2025Article
- The Startle Response and Prepulse Inhibition in Psychosis and Violence: A Combined Electromyography and Electroencephalography Study.Schizophrenia bulletin open · 2025Article
- Intranasal oxytocin interacts with testosterone reactivity to modulate parochial altruism.Communications psychology · 2024Article
- Hostile Attribution Bias Shapes Neural Synchrony in the Left Ventromedial Prefrontal Cortex during Ambiguous Social Narratives.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Characterizing the role of impulsivity in costly, reactive aggression using a novel paradigm.Behavior research methods · 2024Article
- Biomarkers for Cognitive Control, Response Inhibition, Aggressivity, Impulsivity, and Violence.Advances in neurobiology · 2024Review
- Intimate partner violence perpetration among veterans: associations with neuropsychiatric symptoms and limbic microstructure.Frontiers in neurology · 2024Article
- A chemical signal in human female tears lowers aggression in males.PLoS biology · 2023Article
- Association Between Aggression and Differential Functional Activity of Neural Regions Implicated in Retaliation.Journal of the American Academy of Child and Adolescent Psychiatry · 2023Article
- Neurobiology of Aggression-Review of Recent Findings and Relationship with Alcohol and Trauma.Biology · 2023Review
- Understanding the Role of Oxidative Stress, Neuroinflammation and Abnormal Myelination in Excessive Aggression Associated with Depression: Recent Input from Mechanistic Studies.International journal of molecular sciences · 2023Review
- The cerebellum during provocation and aggressive behaviour: A 7 T fMRI study.Imaging neuroscience (Cambridge, Mass.) · 2023Article
Corrections and comments
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Authors and funding
11 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The ability to successfully suppress impulses and angry affect is fundamental to control aggressive reactions following provocations. The aim of this study was to examine neural responses to provocations and aggression using a laboratory model of reactive aggression. We used a novel functional magnetic resonance imaging point-subtraction aggression paradigm in 44 men, of whom 18 were incarcerated violent offenders and 26 were control non-offenders. We measured brain activation following provocations (monetary subtractions), while the subjects had the possibility to behave aggressively or pursue monetary rewards. The violent offenders behaved more aggressively than controls (aggression frequency 150 vs 84, P = 0.03) and showed significantly higher brain reactivity to provocations within the amygdala and striatum, as well as reduced amygdala-prefrontal and striato-prefrontal connectivity. Amygdala reactivity to provocations was positively correlated with task-related behavior in the violent offenders. Across groups, striatal and prefrontal reactivity to provocations was positively associated with trait anger and trait aggression. These results suggest that violent individuals display abnormally high neural sensitivity to social provocations, a sensitivity related to aggressive behavior. These findings provide novel insight into the neural pathways that are sensitive to provocations, which is critical to more effectively shaped interventions that aim to reduce pathological aggressive behavior.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.