ArticleJournal of experimental botany2017
Subcellular localization of Arabidopsis arogenate dehydratases suggests novel and non-enzymatic roles.
Article in Journal of experimental botany, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Loss ofPlants (Basel, Switzerland) · 2026Article
- Integrated Transcriptomic and Metabolomic Analyses Shed Light on the Regulation of Aromatic Amino Acid Biosynthesis in a Novel Albino Tea (Current issues in molecular biology · 2025Article
- Maize big embryo 6 reveals roles of plastidial and cytosolic prephenate aminotransferases in seed and plant development.The Plant cell · 2025Article
- Soybean AROGENATE DEHYDRATASES (GmADTs): involvement in the cytosolic isoflavonoid metabolon or trans-organelle continuity?Frontiers in plant science · 2024Article
- Arogenate dehydratases: unique roles in light-directed development during the seed-to-seedling transition inFrontiers in plant science · 2023Article
- Effects of the microbial community on the formation of volatile compounds and biogenic amines during the traditional brewing ofCurrent research in food science · 2022Article
- VARIABLE PRIORITIZATION IN NONLINEAR BLACK BOX METHODS: A GENETIC ASSOCIATION CASE STUDYThe annals of applied statistics · 2019Article
- Redirecting Primary Metabolism to Boost Production of Tyrosine-Derived Specialised Metabolites in Planta.Scientific reports · 2018Article
- Plastidial NAD-Dependent Malate Dehydrogenase: A Moonlighting Protein Involved in Early Chloroplast Development through Its Interaction with an FtsH12-FtsHi Protease Complex.The Plant cell · 2018Article
- LALFPlant biotechnology journal · 2018Article
- Moonlighting proteins: putting the spotlight on enzymes.Plant signaling & behavior · 2018Article
- Plastid Envelope-Localized Proteins Exhibit a Stochastic Spatiotemporal Relationship to Stromules.Frontiers in plant science · 2018Article
- Stromules: Probing Formation and Function.Plant physiology · 2018Review
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Authors and funding
5 authors.
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Abstract
Arogenate dehydratases (ADTs) catalyze the final step in phenylalanine biosynthesis in plants. The Arabidopsis thaliana genome encodes a family of six ADTs capable of decarboxylating/dehydrating arogenate into phenylalanine. Using cyan fluorescent protein (CFP)-tagged proteins, the subcellular localization patterns of all six A. thaliana ADTs were investigated in intact Nicotiana benthamiana and A. thaliana leaf cells. We show that A. thaliana ADTs localize to stroma and stromules (stroma-filled tubules) of chloroplasts. This localization pattern is consistent with the enzymatic function of ADTs as many enzymes required for amino acid biosynthesis are primarily localized to chloroplasts, and stromules are thought to increase metabolite transport from chloroplasts to other cellular compartments. Furthermore, we provide evidence that ADTs have additional, non-enzymatic roles. ADT2 localizes in a ring around the equatorial plane of chloroplasts or to a chloroplast pole, which suggests that ADT2 is a component of the chloroplast division machinery. In addition to chloroplasts, ADT5 was also found in nuclei, again suggesting a non-enzymatic role for ADT5. We also show evidence that ADT5 is transported to the nucleus via stromules. We propose that ADT2 and ADT5 are moonlighting proteins that play an enzymatic role in phenylalanine biosynthesis and a second role in chloroplast division or transcriptional regulation, respectively.
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