ArticleGenome biology and evolution2017
Conserved Patterns of Sex Chromosome Dosage Compensation in the Lepidoptera (WZ/ZZ): Insights from a Moth Neo-Z Chromosome.
Article in Genome biology and evolution, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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24 citing papers in PubMed, 65 citations in OpenAlex.
- Widespread male-female expression imbalance of X-linked genes across phrynosomatid lizards.Molecular biology and evolution · 2026Article
- Chromatin Landscape Is Associated With Sex-Biased Expression and Drosophila-Like Dosage Compensation of the Z Chromosome in Artemia franciscana.Molecular biology and evolution · 2025Article
- Sex Chromosome Dosage Compensation in Insects.Insects · 2025Review
- Hierarchical architecture of neo-sex chromosomes and accelerated adaptive evolution in tortricid moths.Genome research · 2025Article
- Sex-biased gene content is associated with sex chromosome turnover in Danaini butterflies.Molecular ecology · 2024Article
- Sex Chromosome Evolution: Hallmarks and Question Marks.Molecular biology and evolution · 2024Review
- The regulation of methylation on the Z chromosome and the identification of multiple novel Male Hyper-Methylated regions in the chicken.PLoS genetics · 2024Article
- Can a Y Chromosome Degenerate in an Evolutionary Instant? A Commentary on Fong et al. 2023.Genome biology and evolution · 2023Article
- Chromatin accessibility, not 5mC methylation covaries with partial dosage compensation in crows.PLoS genetics · 2023Article
- Diverse Molecular Mechanisms Underlying Microbe-Inducing Male Killing in the Moth Homona magnanima.Applied and environmental microbiology · 2023Article
- Masculinizer-induced dosage compensation is achieved by transcriptional downregulation of both copies of Z-linked genes in the silkworm,Biology letters · 2022Article
- Dosage compensation inProceedings of the National Academy of Sciences of the United States of America · 2022Article
- Manipulating Insect Sex Determination Pathways for Genetic Pest Management: Opportunities and Challenges.Frontiers in bioengineering and biotechnology · 2022Review
- Thermosensitive sex chromosome dosage compensation in ZZ/ZW softshell turtles,Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2021Article
- RADSex: A computational workflow to study sex determination using restriction site-associated DNA sequencing data.Molecular ecology resources · 2021Article
- The landscape of lncRNAs in Cydia pomonella provides insights into their signatures and potential roles in transcriptional regulation.BMC genomics · 2021Article
- Sex Chromosome Evolution: So Many Exceptions to the Rules.Genome biology and evolution · 2020Review
- Dichotomy of Dosage Compensation along the Neo Z Chromosome of the Monarch Butterfly.Current biology : CB · 2019Article
- Multilayered Tuning of Dosage Compensation and Z-Chromosome Masculinization in the Wood White (Leptidea sinapis) Butterfly.Genome biology and evolution · 2019Article
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3 authors at 2 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Where previously described, patterns of sex chromosome dosage compensation in the Lepidoptera (moths and butterflies) have several unusual characteristics. Other female-heterogametic (ZW/ZZ) species exhibit female Z-linked expression that is reduced compared with autosomal expression and male Z expression. In the Lepidoptera, however, Z expression typically appears balanced between sexes but overall reduced relative to autosomal expression, that is Z ≈ ZZ < AA. This pattern is not easily reconciled with theoretical expectations for the evolution of sex chromosome dosage compensation. Moreover, conflicting results linger due to discrepancies in data analyses and tissues sampled among lepidopterans. To address these issues, we performed RNA-seq to analyze sex chromosome dosage compensation in the codling moth, Cydia pomonella, which is a species from the earliest diverging lepidopteran lineage yet examined for dosage compensation and has a neo-Z chromosome resulting from an ancient Z:autosome fusion. While supported by intraspecific analyses, the Z ≈ ZZ < AA pattern was further evidenced by comparative study using autosomal orthologs of C. pomonella neo-Z genes in outgroup species. In contrast, dosage compensation appears to be absent in reproductive tissues. We thus argue that inclusion of reproductive tissues may explain the incongruence from a prior study on another moth species and that patterns of dosage compensation are likely conserved in the Lepidoptera. Notably, this pattern appears convergent with patterns in eutherian mammals (X ≈ XX < AA). Overall, our results contribute to the notion that the Lepidoptera present challenges both to classical theories regarding the evolution of sex chromosome dosage compensation and the emerging view of the association of dosage compensation with sexual heterogamety.
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