ArticleGenome biology and evolution2017
Cross-Species Genome-Wide Identification of Evolutionary Conserved MicroProteins.
Article in Genome biology and evolution, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 34 citations in OpenAlex.
- Microproteins in Metabolic Biology: Emerging Functions and Potential Roles as Nutrient-Linked Biomarkers.International journal of molecular sciences · 2025Review
- The 'non-conventional' peptidome: A new layer in plant regulatory mechanisms.Plant communications · 2025Review
- Emerging roles for microproteins as critical regulators of endoplasmic reticulum function and cellular homeostasis.Seminars in cell & developmental biology · 2025Review
- Noncanonical microprotein regulation of immunity.Molecular therapy : the journal of the American Society of Gene Therapy · 2024Review
- Genome-wide association study and genotypic variation for the major tocopherol content in rice grain.Frontiers in plant science · 2024Article
- Genome-wide identification and expression analysis of the AS2/LOB gene family in physic nut.Frontiers in plant science · 2024Article
- Microproteins-Discovery, structure, and function.Proteomics · 2023Review
- De novo birth of functional microproteins in the human lineage.Cell reports · 2022Article
- Review
- Short open reading frames (sORFs) and microproteins: an update on their identification and validation measures.Journal of biomedical science · 2022Review
- Evolutionary Perspective and Expression Analysis of Intronless Genes Highlight the Conservation of Their Regulatory Role.Frontiers in genetics · 2021Article
- Heterologous microProtein expression identifies LITTLE NINJA, a dominant regulator of jasmonic acid signaling.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Global Analysis of Cereal microProteins Suggests Diverse Roles in Crop Development and Environmental Adaptation.G3 (Bethesda, Md.) · 2020Article
- Allosteric deactivation of PIFs and EIN3 by microproteins in light control of plant development.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Structural evolution drives diversification of the large LRR-RLK gene family.The New phytologist · 2020Article
- Approaches to identify and characterize microProteins and their potential uses in biotechnology.Cellular and molecular life sciences : CMLS · 2018Review
- Synthetic MicroProteins: Versatile Tools for Posttranslational Regulation of Target Proteins.Plant physiology · 2018Article
- Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
MicroProteins are small single-domain proteins that act by engaging their targets into different, sometimes nonproductive protein complexes. In order to identify novel microProteins in any sequenced genome of interest, we have developed miPFinder, a program that identifies and classifies potential microProteins. In the past years, several microProteins have been discovered in plants where they are mainly involved in the regulation of development by fine-tuning transcription factor activities. The miPFinder algorithm identifies all up to date known plant microProteins and extends the microProtein concept beyond transcription factors to other protein families. Here, we reveal potential microProtein candidates in several plant and animal reference genomes. A large number of these microProteins are species-specific while others evolved early and are evolutionary highly conserved. Most known microProtein genes originated from large ancestral genes by gene duplication, mutation and subsequent degradation. Gene ontology analysis shows that putative microProtein ancestors are often located in the nucleus, and involved in DNA binding and formation of protein complexes. Additionally, microProtein candidates act in plant transcriptional regulation, signal transduction and anatomical structure development. MiPFinder is freely available to find microProteins in any genome and will aid in the identification of novel microProteins in plants and animals.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.