ArticleGenome biology and evolution2017
Recombination-Mediated Host Adaptation by Avian Staphylococcus aureus.
Article in Genome biology and evolution, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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Who cites it
39 citing papers in PubMed, 50 citations in OpenAlex.
- Antimicrobial-resistant Staphylococcus aureus isolated from Australian wildlife admitted to a veterinary hospital.Australian veterinary journal · 2026Article
- Genomic insights into specialized and primary metabolism gene clusters in methicillin-resistant Staphylococcus aureus from Egyptian community settings.BMC genomics · 2026Article
- CharacterizingmSystems · 2025Article
- Varying phylogenetic signal in susceptibility to four bacterial pathogens across species of Drosophilidae.Proceedings. Biological sciences · 2025Article
- Methicillin-sensitiveMicrobial genomics · 2025Article
- Phylogenomic insights into LA-MRSA from Argentine pig farm environments: novelFrontiers in microbiology · 2025Article
- Bacteriophage-driven emergence and expansion of Staphylococcus aureus in rodent populations.PLoS pathogens · 2024Article
- Mechanisms of host adaptation by bacterial pathogens.FEMS microbiology reviews · 2024Review
- Genetic Complexity of CC5Pathogens (Basel, Switzerland) · 2024Article
- Commercial farmed swine harbour a variety of pathogenic bacteria and antimicrobial resistance genes.Journal of medical microbiology · 2024Article
- Staphylococcus aureus Carriage in the Nasotracheal Cavities of White Stork Nestlings (Ciconia ciconia) in Spain: Genetic Diversity, Resistomes and Virulence Factors.Microbial ecology · 2023Article
- Virulence Mechanisms of Staphylococcal Animal Pathogens.International journal of molecular sciences · 2023Review
- Leaky barriers to gene sharing between locally co-existing coagulase-negative Staphylococcus species.Communications biology · 2023Article
- Prevalence, multiple antibiotic resistance and virulence profile of methicillin-resistantFrontiers in cellular and infection microbiology · 2023Article
- Methicillin-ResistantVeterinary sciences · 2022Review
- Antimicrobial Resistance and Clonal Lineages ofMicroorganisms · 2022Article
- Shared antibiotic resistance and virulence genes in Staphylococcus aureus from diverse animal hosts.Scientific reports · 2022Article
- Antimicrobial resistance in the globalized food chain: a One Health perspective applied to the poultry industry.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2022Review
- MRSA compendium of epidemiology, transmission, pathophysiology, treatment, and prevention within one health framework.Frontiers in microbiology · 2022Review
- Extensive Horizontal Gene Transfer within and between Species of Coagulase-Negative Staphylococcus.Genome biology and evolution · 2021Article
Corrections and comments
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Authors and funding
20 authors at 8 institutions in 5 countries.
Funding
Abstract
Staphylococcus aureus are globally disseminated among farmed chickens causing skeletal muscle infections, dermatitis, and septicaemia. The emergence of poultry-associated lineages has involved zoonotic transmission from humans to chickens but questions remain about the specific adaptations that promote proliferation of chicken pathogens. We characterized genetic variation in a population of genome-sequenced S. aureus isolates of poultry and human origin. Genealogical analysis identified a dominant poultry-associated sequence cluster within the CC5 clonal complex. Poultry and human CC5 isolates were significantly distinct from each other and more recombination events were detected in the poultry isolates. We identified 44 recombination events in 33 genes along the branch extending to the poultry-specific CC5 cluster, and 47 genes were found more often in CC5 poultry isolates compared with those from humans. Many of these gene sequences were common in chicken isolates from other clonal complexes suggesting horizontal gene transfer among poultry associated lineages. Consistent with functional predictions for putative poultry-associated genes, poultry isolates showed enhanced growth at 42 °C and greater erythrocyte lysis on chicken blood agar in comparison with human isolates. By combining phenotype information with evolutionary analyses of staphylococcal genomes, we provide evidence of adaptation, following a human-to-poultry host transition. This has important implications for the emergence and dissemination of new pathogenic clones associated with modern agriculture.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.