ArticleGenome biology and evolution2017
The Chlamydia suis Genome Exhibits High Levels of Diversity, Plasticity, and Mobile Antibiotic Resistance: Comparative Genomics of a Recent Livestock Cohort Shows Influence of Treatment Regimes.
Article in Genome biology and evolution, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
22 citing papers in PubMed, 35 citations in OpenAlex.
- Influence of Chlamydia suis on reproductive outcome in farms with and without tetracycline treatment of sows.Veterinary research · 2026Article
- Pangenome-Wide Association Study in theInternational journal of molecular sciences · 2024Article
- Chlamydiosis in Animals.Animals : an open access journal from MDPI · 2024Review
- Article
- Zoonotic and other veterinary chlamydiae - an update, the role of the plasmid and plasmid-mediated transformation.Pathogens and disease · 2024Review
- Important considerations regarding the widespread use of doxycycline chemoprophylaxis against sexually transmitted infections.The Journal of antimicrobial chemotherapy · 2023Review
- Review
- Genome organization and genomics inFrontiers in cellular and infection microbiology · 2023Review
- Suspected chlamydial foetal loss highlights the need for standardised on-farm protocols.Australian veterinary journal · 2022Article
- Detection of Acquired Antibiotic Resistance Genes in Domestic Pig (Antibiotics (Basel, Switzerland) · 2022Article
- The Impact of Lateral Gene Transfer inFrontiers in cellular and infection microbiology · 2022Review
- Characteristics ofPathogens (Basel, Switzerland) · 2021Article
- A comprehensive review on avian chlamydiosis: a neglected zoonotic disease.Tropical animal health and production · 2021Review
- Transferrins Reduce Replication ofPathogens (Basel, Switzerland) · 2021Article
- Comprehensive genome analysis and comparisons of the swine pathogen, Chlamydia suis reveals unique ORFs and candidate host-specificity factors.Pathogens and disease · 2021Article
- Generation of Tetracycline and Rifamycin ResistantFrontiers in microbiology · 2021Article
- Isolation of Tetracycline-ResistantAntibiotics (Basel, Switzerland) · 2020Article
- Chlamydia pan-genomic analysis reveals balance between host adaptation and selective pressure to genome reduction.BMC genomics · 2019Article
- Mini Review: Antimicrobial Control of Chlamydial Infections in Animals: Current Practices and Issues.Frontiers in microbiology · 2019Article
- Evaluating the Antibiotic Susceptibility ofFrontiers in microbiology · 2018Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chlamydia suis is an endemic pig pathogen, belonging to a fascinating genus of obligate intracellular pathogens. Of particular interest, this is the only chlamydial species to have naturally acquired genes encoding for tetracycline resistance. To date, the distribution and mobility of the Tet-island are not well understood. Our study focused on whole genome sequencing of 29 C. suis isolates from a recent porcine cohort within Switzerland, combined with data from USA tetracycline-resistant isolates. Our findings show that the genome of C. suis is very plastic, with unprecedented diversity, highly affected by recombination and plasmid exchange. A large diversity of isolates circulates within Europe, even within individual Swiss farms, suggesting that C. suis originated around Europe. New World isolates have more restricted diversity and appear to derive from European isolates, indicating that historical strain transfers to the United States have occurred. The architecture of the Tet-island is variable, but the tetA(C) gene is always intact, and recombination has been a major factor in its transmission within C. suis. Selective pressure from tetracycline use within pigs leads to a higher number of Tet-island carrying isolates, which appear to be lost in the absence of such pressure, whereas the loss or gain of the Tet-island from individual strains is not observed. The Tet-island appears to be a recent import into the genome of C. suis, with a possible American origin.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.