ArticleAmerican journal of hypertension2017
Association of Maternal Plasma Folate and Cardiometabolic Risk Factors in Pregnancy with Elevated Blood Pressure of Offspring in Childhood.
Article in American journal of hypertension, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16 citing papers in PubMed, 25 citations in OpenAlex.
- Associations of antenatal micronutrient supplementation with adolescent blood pressure: evidence from a 14-year follow-up study of a randomized controlled trial.BMC public health · 2025Trial
- Maternal nutritional imbalance during pregnancy and the development of fetal-origin cardiovascular diseases.Frontiers in nutrition · 2026Review
- Biological, dietetic and pharmacological properties of vitamin BNPJ science of food · 2025Review
- The impact of folic acid/VB12 deficiency on essential hypertension in children and adolescents: from a nested case-control and a cohort study.Journal of human hypertension · 2024Article
- Risk of Excess Maternal Folic Acid Supplementation in Offspring.Nutrients · 2024Review
- Early Life Origins of Cardio-Metabolic Outcomes in Boston Birth Cohort: Review of Findings and Future directions.Precision nutrition · 2023Article
- Association of Placental Pathology With Childhood Blood Pressure Among Children Born Preterm.American journal of hypertension · 2021Article
- B-vitamins and metabolic syndrome in Mesoamerican children and their adult parents.Public health nutrition · 2021Article
- One carbon metabolism and early development: a diet-dependent destiny.Trends in endocrinology and metabolism: TEM · 2021Review
- Associations of Early Pregnancy and Neonatal Circulating Folate, Vitamin B-12, and Homocysteine Concentrations with Cardiometabolic Risk Factors in Children at 10 y of Age.The Journal of nutrition · 2021Article
- Associations Between Maternal Nutrition in Pregnancy and Child Blood Pressure at 4-6 Years: A Prospective Study in a Community-Based Pregnancy Cohort.The Journal of nutrition · 2021Article
- A prospective birth cohort study on cord blood folate subtypes and risk of autism spectrum disorder.The American journal of clinical nutrition · 2020Article
- In utero exposure to mercury and childhood overweight or obesity: counteracting effect of maternal folate status.BMC medicine · 2019Article
- Vitamin D Trajectories From Birth to Early Childhood and Elevated Systolic Blood Pressure During Childhood and Adolescence.Hypertension (Dallas, Tex. : 1979) · 2019Article
- Maternal postpartum plasma folate status and preterm birth in a high-risk US population.Public health nutrition · 2019Observational
- Folate Nutrition Status in Mothers of the Boston Birth Cohort, Sample of a US Urban Low-Income Population.American journal of public health · 2018Article
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7 authors at 5 institutions in 2 countries.
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Abstract
backgroundThe prevalence of childhood elevated blood pressure (BP) has increased in the United States, particularly among African Americans. The influence of maternal plasma folate levels, alone or in combination with maternal cardiometabolic risk factors (hypertensive disorders, diabetes, and prepregnancy obesity), on child systolic BP (SBP) has not been examined in a prospective birth cohort. We hypothesize that adequate maternal folate levels can reduce the risk of elevated SBP in children born to mothers with cardiometabolic risk factors.
methodsThis study included 1,290 mother-child dyads (875 African Americans (67.8%)) recruited at birth and followed prospectively up to age 9 years from 2003 to 2014 at the Boston Medical Center. Child SBP percentile was calculated according to US reference data and elevated SBP was defined as SBP ≥75th percentile.
resultsMaternal folate levels, overall, were not associated with child SBP. However, we found a significant multiplicative interaction between maternal cardiometabolic risk factors and maternal folate levels (Pinteraction = 0.015) on childhood elevated SBP. Among children born to mothers with any cardiometabolic risk factors, those whose mothers had folate levels above (vs. below) the median had 40% lower odds of elevated childhood SBP (odds ratio = 0.60, 95% confidence interval: 0.40-0.90). The associations did not differ appreciably in analyses restricted to African Americans, and they were not explained by gestational age, size at birth, prenatal folate intake, or breastfeeding.
conclusionsFindings from our urban minority birth cohort suggest that higher levels of maternal folate may help counteract the adverse associations of maternal cardiometabolic risk factors on child SBP.
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