ArticleSocial cognitive and affective neuroscience2017
Sex differences in the development of emotion circuitry in adolescents at risk for substance abuse: a longitudinal fMRI study.
Article in Social cognitive and affective neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.
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Who cites it
32 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The brain in social context: A systematic review of substance use and social processing from adolescence to young adulthood.Developmental cognitive neuroscience · 2022Pooled it
- How adolescents' working memory abilities relate to their alcohol craving in real-life contexts depends on biological sex.Drug and alcohol dependence · 2021Trial
- Anticipation of monetary reward in amygdala, insula, caudate are predictors of pleasure sensitivity to d-Amphetamine administration.Drug and alcohol dependence · 2020Trial
- Screen exposure before age two and developmental outcomes in early childhood: a national cross-sectional study in China.BMC public health · 2026Article
- The effects of polygenic risks for alcohol misuse on negative emotion processing in young adult binge drinkers.Translational psychiatry · 2025Article
- Parental Alcohol Use Predicts Neural Emotion Reactivity and Substance Use Intentions in Early Adolescence.The Journal of early adolescence · 2025Article
- Exploring the impact of biological sex on intrinsic connectivity networks in PTSD: A data-driven approach.Progress in neuro-psychopharmacology & biological psychiatry · 2025Article
- A narrative review on alcohol use in women: insight into the telescoping hypothesis from a biopsychosocial perspective.The American journal of drug and alcohol abuse · 2025Review
- Sex-specific differences in brain activity dynamics of youth with a family history of substance use disorder.Nature. Mental health · 2025Article
- Genetic-Dependent Brain Signatures of Resilience: Interactions among Childhood Abuse, Genetic Risks and Brain Function.bioRxiv : the preprint server for biology · 2024Article
- Abnormal large-scale brain functional network dynamics in social anxiety disorder.CNS neuroscience & therapeutics · 2024Article
- Large-scale brain functional network abnormalities in social anxiety disorder.Psychological medicine · 2023Article
- The association of amygdala-insula functional connectivity and adolescent e-cigarette use via sleep problems and depressive symptoms.Addictive behaviors · 2022Article
- Large-scale dysfunctional white matter and grey matter networks in patients with social anxiety disorder.iScience · 2022Article
- A novel method for estimating connectivity-based parcellation of the human brain from diffusion MRI: Application to an aging cohort.Human brain mapping · 2022Article
- Binge drinking indirectly predicts a negative emotional memory bias through coping motivations and depressive symptoms: The role of sex/gender.Frontiers in psychology · 2022Article
- Distinct Effects of Social Stress on Working Memory in Obsessive-Compulsive Disorder.Neuroscience bulletin · 2021Article
- Sex/gender differences in brain function and structure in alcohol use: A narrative review of neuroimaging findings over the last 10 years.Journal of neuroscience research · 2021Review
- Novel polygenic risk score as a translational tool linking depression-related changes in the corticolimbic transcriptome with neural face processing and anhedonic symptoms.Translational psychiatry · 2020Article
- Changes in functional connectivity with cognitive behavioral therapy for social anxiety disorder predict outcomes at follow-up.Behaviour research and therapy · 2020Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
There is substantial evidence for behavioral sex differences in risk trajectories for alcohol and substance use, with internalizing factors such as negative affectivity contributing more to female risk. Because the neural development of emotion circuitry varies between males and females across adolescence, it represents a potential mechanism by which underlying neurobiology contributes to risk for substance use. Longitudinal functional magnetic resonance imaging was conducted in males and females (n = 18 each) with a family history of alcohol use disorders starting at ages 8-13 years. Participants performed an affective word task during functional magnetic resonance imaging at 1- to 2-year intervals, covering the age range of 8.5-17.6 years (3-4 scans per participant). Significant age-related sex differences were found in the right amygdala and right precentral gyrus for the negative vs neutral word condition. Males showed a significant decrease in both amygdala and precentral gyrus activation with age, whereas the response in females persisted. The subjective experience of internalizing symptomatology significantly increased with age for females but not for males. Taken together, these results reveal sex differences in negative affect processing in at-risk adolescents, and offer longitudinal neural evidence for female substance use risk through internalizing pathways.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.