ArticleThe ISME journal2017
Integrated metabolism in sponge-microbe symbiosis revealed by genome-centered metatranscriptomics.
Article in The ISME journal, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 68 papers.
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Who cites it
68 citing papers in PubMed, 131 citations in OpenAlex.
- Branched-chain amino acid assimilation enables mixotrophy of ammonia-oxidizing archaeal sponge symbionts.Science advances · 2026Article
- Ammonia oxidation and recalcitrant carbon degradation fuel mixotrophic growth in the symbiont community of a deep-sea sponge.Microbiome · 2026Article
- Low Abundance Taxa Show Diverse Microbial Symbiotic Interactions With the Freshwater Sponge, Radiospongilla crateriformis, Pre and Post Gemmulation.Environmental microbiology reports · 2026Article
- New insights into the microbiome of the deep-sea spongeMicrobial genomics · 2026Article
- A New Classification Framework to Understand Evolutionary Transitions in Individuality.BioEssays : news and reviews in molecular, cellular and developmental biology · 2026Review
- Diversity and composition of sponge-associated microbiomes from Korean sponges revealed by full-length 16S rRNA analysis.Scientific reports · 2025Article
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- The archaeal classmBio · 2025Article
- From Sea to Freshwater: Shared and Unique Microbial Traits in Sponge Associated Prokaryotic Communities.Current microbiology · 2025Article
- Article
- Genome-scale metabolic modelling reveals interactions and key roles of symbiont clades in a sponge holobiont.Nature communications · 2024Article
- Evidence of habitat specificity in sponge microbiomes from Antarctica.Environmental microbiome · 2024Article
- Decoupling of strain- and intrastrain-level interactions of microbiomes in a sponge holobiont.Nature communications · 2024Article
- Impacts of humic substances, elevated temperature, and UVB radiation on bacterial communities of the marine sponge Chondrilla sp.FEMS microbiology ecology · 2024Article
- High compositional and functional similarity in the microbiome of deep-sea sponges.The ISME journal · 2024Article
- Co-occurring nitrifying symbiont lineages are vertically inherited and widespread in marine sponges.The ISME journal · 2024Article
- Species-specific relationships between deep sea sponges and their symbiotic Nitrosopumilaceae.The ISME journal · 2023Article
- Taurine as a key intermediate for host-symbiont interaction in the tropical sponge Ianthella basta.The ISME journal · 2023Article
- Early genome erosion and internal phage-symbiont-host interaction in the endosymbionts of a cold-seep tubeworm.iScience · 2023Article
- Future ocean conditions induce necrosis, microbial dysbiosis and nutrient cycling imbalance in the reef sponge Stylissa flabelliformis.ISME communications · 2023Article
8 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Despite an increased understanding of functions in sponge microbiomes, the interactions among the symbionts and between symbionts and host are not well characterized. Here we reconstructed the metabolic interactions within the sponge Cymbastela concentrica microbiome in the context of functional features of symbiotic diatoms and the host. Three genome bins (CcPhy, CcNi and CcThau) were recovered from metagenomic data of C. concentrica, belonging to the proteobacterial family Phyllobacteriaceae, the Nitrospira genus and the thaumarchaeal order Nitrosopumilales. Gene expression was estimated by mapping C. concentrica metatranscriptomic reads. Our analyses indicated that CcPhy is heterotrophic, while CcNi and CcThau are chemolithoautotrophs. CcPhy expressed many transporters for the acquisition of dissolved organic compounds, likely available through the sponge's filtration activity and symbiotic carbon fixation. Coupled nitrification by CcThau and CcNi was reconstructed, supported by the observed close proximity of the cells in fluorescence in situ hybridization. CcPhy facultative anaerobic respiration and assimilation by diatoms may consume the resulting nitrate. Transcriptional analysis of diatom and sponge functions indicated that these organisms are likely sources of organic compounds, for example, creatine/creatinine and dissolved organic carbon, for other members of the symbiosis. Our results suggest that organic nitrogen compounds, for example, creatine, creatinine, urea and cyanate, fuel the nitrogen cycle within the sponge. This study provides an unprecedented view of the metabolic interactions within sponge-microbe symbiosis, bridging the gap between cell- and community-level knowledge.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.