Evidence map›Paper›PMID 28338602›Full record

ArticleMolecules (Basel, Switzerland)2017

Design and Synthesis of Novel Pyrazole-Substituted Different Nitrogenous Heterocyclic Ring Systems as Potential Anti-Inflammatory Agents.

Eman S Nossier, Hoda H Fahmy, Nagy M Khalifa, Wafaa I El-Eraky, Marawan A Baset

Abstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Article
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  8. Synthesis andInternational journal of molecular sciences · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Eman S NossierDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy (Girls), Al-Azhar University, Cairo 11754, Egypt. emy28_s@hotmail.com.
Hoda H FahmyDepartment of Therapeutical Chemistry, Pharmaceutical and Drug Industries Division, National Research Centre, Giza 12622, Egypt. hh_fahmy@yahoo.com.
Nagy M KhalifaDepartment of Therapeutical Chemistry, Pharmaceutical and Drug Industries Division, National Research Centre, Giza 12622, Egypt. nagykhalifa@hotmail.com.
Wafaa I El-ErakyPharmacology Department, National Research Centre, Dokki, Cairo 12622, Egypt. wafaa_nrc@yahoo.com.
Marawan A BasetPharmacology Department, National Research Centre, Dokki, Cairo 12622, Egypt. dr.marawan@gmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

With the aim of developing novel anti-inflammatory scaffolds, a new series of pyrazole-substituted various nitrogenous heterocyclic ring systems at C-4 position were synthesized through different chemical reactions and validated by means of spectral and elemental data. The new obtained compounds were investigated for their anti-inflammatory activity using the carrageenan-induced paw edema standard technique and revealed that, compound

Indexed as

Drug DesignAnimalsAnti-Inflammatory AgentsCarrageenanCelecoxibCyclooxygenase InhibitorsEdemaHeterocyclic CompoundsInjectionsMaleMolecular Docking SimulationPiperidinesPyrazolesRatsRimonabantAnti-Inflammatory AgentsCarrageenanCelecoxibCyclooxygenase InhibitorsHeterocyclic CompoundsPiperidinespyrazolePyrazolesRimonabant1,3-diaryl pyrazole derivativesanti-inflammatory activitysynthesis

Identifiers

PMID28338602
PMCPMC6154115

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.