Evidence map›Paper›PMID 28338419›Full record

ArticleTissue engineering. Part A2017

Competitive Protein Binding Influences Heparin-Based Modulation of Spatial Growth Factor Delivery for Bone Regeneration.

Marian H Hettiaratchi, Catherine Chou, Nicholas Servies, Johanna M Smeekens, Albert Cheng, Camden Esancy, Ronghu Wu, Todd C McDevitt, Robert E Guldberg, Laxminarayanan Krishnan

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Tissue engineering. Part A, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
7.0field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 37 citations in OpenAlex.

  1. Article
  2. Article
  3. Amniotic membrane attenuates heterotopic ossification following high-dose bone morphogenetic protein-2 treatment of segmental bone defects.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2023
    Article
  4. Review
  5. Review
  6. Review
  7. Advances in Growth Factor Delivery for Bone Tissue Engineering.International journal of molecular sciences · 2021
    Review
  8. Review
  9. Article
  10. Immobilization of Growth Factors for Cell Therapy Manufacturing.Frontiers in bioengineering and biotechnology · 2020
    Review
  11. Article
  12. Article
  13. Review
  14. Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Marian H Hettiaratchi1 The Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University , Atlanta, Georgia .
Catherine Chou1 The Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University , Atlanta, Georgia .
Nicholas Servies1 The Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University , Atlanta, Georgia .
Johanna M Smeekens2 School of Chemistry and Biochemistry, Georgia Institute of Technology , Atlanta, Georgia .
Albert Cheng3 The Parker H. Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology , Atlanta, Georgia .
Camden Esancy3 The Parker H. Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology , Atlanta, Georgia .
Ronghu Wu2 School of Chemistry and Biochemistry, Georgia Institute of Technology , Atlanta, Georgia .
Todd C McDevitt5 The Gladstone Institute of Cardiovascular Disease , San Francisco, California.
Robert E Guldberg3 The Parker H. Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology , Atlanta, Georgia .
Laxminarayanan Krishnan3 The Parker H. Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology , Atlanta, Georgia .
Georgia Institute of Technology · USGladstone Institutes · USThe Wallace H. Coulter Department of Biomedical Engineering · US

Funding

Stem Cell Morphogen Delivery via Engineered BiomaterialsR01AR062006 · NIAMS · J. DAVID GLADSTONE INSTITUTES · PI MCDEVITT, TODD C · 2011 to 2015
$1.9M
NIAMS NIH HHS R01 AR062006
6 · The paper itself

Abstract

Tissue engineering strategies involving the in vivo delivery of recombinant growth factors are often limited by the inability of biomaterials to spatially control diffusion of the delivered protein within the site of interest. The poor spatiotemporal control provided by porous collagen sponges, which are used for the clinical delivery of bone morphogenetic protein-2 (BMP-2) for bone regeneration, has necessitated the use of supraphysiological protein doses, leading to inflammation and heterotopic ossification. This study describes a novel tissue engineering strategy to spatially control rapid BMP-2 diffusion from collagen sponges in vivo by creating a high-affinity BMP-2 sink around the collagen sponge. We designed an electrospun poly-ɛ-caprolactone nanofiber mesh containing physically entrapped heparin microparticles, which have been previously demonstrated to bind and retain large amounts of BMP-2. Nanofiber meshes containing 0.05 and 0.10 mg of microparticles/cm

Indexed as

Bone Morphogenetic Protein 2CollagenFemurAnimalsBone RegenerationDrug Delivery SystemsFemaleRatsRats, Sprague-DawleyBmp2 protein, ratBone Morphogenetic Protein 2Collagenbone morphogenetic proteincollagen spongeheparin microparticlesheterotopic ossificationnanofiber meshspatial control of bone regeneration

Identifiers

PMID28338419
PMCPMC5549832
OpenAlexW2597440279

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.