ArticleScientific reports2017
A distinct bacterial dysbiosis associated skin inflammation in ovine footrot.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.
- Meta-Analysis of Bovine Digital Dermatitis Microbiota Reveals Distinct Microbial Community Structures Associated With Lesions.Frontiers in cellular and infection microbiology · 2021Pooled it
- Hoof, Vaginal and Milk Microbiota Alterations in Dairy Cows with Foot Rot.Animals : an open access journal from MDPI · 2026Article
- Variation in the early-life interdigital skin microbiota of lambs in a commercial sheep flock.Frontiers in veterinary science · 2026Article
- Rapid serogroup classification of the footrot pathogenFrontiers in veterinary science · 2025Article
- Natural Mycoplasma Infection Reduces Expression of Pro-Inflammatory Cytokines in Response to Ovine Footrot Pathogens.Animals : an open access journal from MDPI · 2022Article
- Differences in composition of interdigital skin microbiota predict sheep and feet that develop footrot.Scientific reports · 2022Article
- The skin microbiota in equine pastern dermatitis: a case-control study of horses in Switzerland.Veterinary dermatology · 2021Article
- DOK3 maintains intestinal homeostasis by suppressing JAK2/STAT3 signaling and S100a8/9 production in neutrophils.Cell death & disease · 2021Article
- A Trifecta of New Insights into Ovine Footrot for Infection Drivers, Immune Response, and Host-Pathogen Interactions.Infection and immunity · 2021Article
- Relationships among bedding materials, bedding bacterial composition and lameness in dairy cows.Animal bioscience · 2021Article
- The dysbiosis of ovine foot microbiome during the development and treatment of contagious ovine digital dermatitis.Animal microbiome · 2021Article
- Sites of persistence of Fusobacterium necrophorum and Dichelobacter nodosus: a paradigm shift in understanding the epidemiology of footrot in sheep.Scientific reports · 2019Article
- DirtyGenes: testing for significant changes in gene or bacterial population compositions from a small number of samples.Scientific reports · 2019Article
- ProbioticFrontiers in microbiology · 2019Article
- Detection and Serogrouping of Dichelobacter nodosus Infection by Use of Direct PCR from Lesion Swabs To Support Outbreak-Specific Vaccination for Virulent Footrot in Sheep.Journal of clinical microbiology · 2018Article
- Article
- A Novel 3D Skin Explant Model to Study Anaerobic Bacterial Infection.Frontiers in cellular and infection microbiology · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
Ovine footrot is a highly prevalent bacterial disease caused by Dichelobacter nodosus and characterised by the separation of the hoof horn from the underlying skin. The role of innate immune molecules and other bacterial communities in the development of footrot lesions remains unclear. This study shows a significant association between the high expression of IL1β and high D. nodosus load in footrot samples. Investigation of the microbial population identified distinct bacterial populations in the different disease stages and also depending on the level of inflammation. Treponema (34%), Mycoplasma (29%) and Porphyromonas (15%) were the most abundant genera associated with high levels of inflammation in footrot. In contrast, Acinetobacter (25%), Corynebacteria (17%) and Flavobacterium (17%) were the most abundant genera associated with high levels of inflammation in healthy feet. This demonstrates for the first time there is a distinct microbial community associated with footrot and high cytokine expression.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.